cholinergic

简明释义

英[ˌkəʊlɪˈnɜːdʒɪk]美[ˌkoʊləˈnərdʒɪk]

adj. 胆碱能的

英英释义

单词用法

同义词

反义词

例句

1.The learning and cognitive deficits observed in AD patients are hypothesized to be partly caused by central cholinergic system dysfunction.

基底前脑胆碱能损伤导致的中枢胆碱能系统功能低下是AD患者认知功能障碍的基础。

2.These fibers are, in fact, mainly cholinergic.

实际上这些纤维主要是胆碱能神经纤维。

3.Effect of skin temperature on the cholinergic sensitivity of the human eccrine sweat gland.

皮肤温度对人体外泌汗腺拟胆碱药敏感性的影响。

4.OBJECTIVE to synthesize and screen tropane derivatives with cholinergic activity and subtype-selectivity of M1 receptor.

目的设计、合成并筛选具有胆碱能活性，且对M1受体有选择性的莨菪烷衍生物。

5.It can be inferred that some pharmacological effects of tetrahydroisoquinolines are probably related to M-cholinergic receptors.

实验结果提示，某些四氢异喹啉类生物碱的药理作用可能与M -胆碱受体有关。

6.Secretion of sweat occurs as result of many factors and is mediated by cholinergic innervation.

汗液的分泌受胆碱能神经支配，是多种因素作用的结果。

7.To study nerve stem cell directional differentiation to cholinergic neuron by adjusting action of promote differentiation factors.

目的通过促分化因子的调节作用对神经干细胞向胆碱能神经元的定向分化进行探讨研究。

8.The doctor prescribed a medication that enhances cholinergic 胆碱能的 activity to help with memory loss.

医生开了一种药物，增强cholinergic 胆碱能的活性，以帮助改善记忆丧失。

9.Certain plants contain compounds that can stimulate cholinergic 胆碱能的 receptors, potentially improving cognitive function.

某些植物含有可以刺激cholinergic 胆碱能的受体的化合物，可能改善认知功能。

10.In Alzheimer's disease, the loss of cholinergic 胆碱能的 neurons contributes to cognitive decline.

在阿尔茨海默病中，cholinergic 胆碱能的神经元的丧失导致认知能力下降。

11.Physiotherapists may use cholinergic 胆碱能的 drugs to enhance muscle contraction during rehabilitation.

物理治疗师可能会使用cholinergic 胆碱能的药物来增强康复期间的肌肉收缩。

12.Research shows that cholinergic 胆碱能的 signaling plays a crucial role in attention and learning.

研究表明，cholinergic 胆碱能的信号在注意力和学习中起着关键作用。

作文

The term cholinergic refers to anything that is related to the neurotransmitter acetylcholine. This neurotransmitter plays a vital role in transmitting signals in the nervous system, particularly in the peripheral and central nervous systems. Understanding the function of cholinergic pathways is crucial for comprehending how our bodies respond to various stimuli and manage numerous physiological processes. For instance, acetylcholine is essential for muscle contraction, memory formation, and the regulation of heart rate. In the context of the nervous system, cholinergic neurons release acetylcholine at synapses, which then binds to specific receptors on the post-synaptic neurons, leading to a variety of responses. There are two main types of receptors for acetylcholine: nicotinic and muscarinic receptors. Nicotinic receptors are found at the neuromuscular junctions and are responsible for stimulating muscle contractions, while muscarinic receptors are found in various organs and tissues, affecting functions like heart rate and glandular secretions. Research into cholinergic systems has significant implications for understanding certain diseases. For example, Alzheimer's disease is associated with a decline in cholinergic activity, leading to cognitive deficits. Therapies aimed at enhancing cholinergic function have been developed to help mitigate some of the symptoms associated with this condition. These treatments often involve the use of acetylcholinesterase inhibitors, which prevent the breakdown of acetylcholine, thereby increasing its availability in the brain. Moreover, the role of cholinergic mechanisms extends beyond just neurodegenerative diseases. Conditions such as myasthenia gravis, where the immune system attacks cholinergic receptors, demonstrate how disruptions in this system can lead to severe muscle weakness. Understanding these mechanisms allows for the development of targeted therapies that can improve patient outcomes. In the realm of pharmacology, various drugs interact with cholinergic systems. For instance, some medications used to treat depression or anxiety may influence cholinergic transmission, highlighting the interconnectedness of neurotransmitter systems in regulating mood and behavior. Additionally, the use of anticholinergic drugs, which block the action of acetylcholine, can lead to side effects such as dry mouth, constipation, and confusion, underscoring the importance of cholinergic activity in maintaining homeostasis. In conclusion, the concept of cholinergic is integral to understanding the complexities of the nervous system and its functions. From muscle control to cognitive processes, acetylcholine and its associated pathways play a significant role in our daily lives. As research continues to unfold, the potential for therapeutic interventions targeting cholinergic systems presents exciting opportunities for improving health outcomes in various neurological and psychological conditions. By delving deeper into the realm of cholinergic signaling, we can better appreciate the intricate balance of neurotransmitters that govern our bodily functions and responses to the environment.

“cholinergic”这个术语指的是与神经递质乙酰胆碱相关的任何事物。该神经递质在传递信号方面起着至关重要的作用，尤其是在外周和中枢神经系统中。理解cholinergic通路的功能对于理解我们身体如何对各种刺激作出反应以及管理众多生理过程至关重要。例如，乙酰胆碱对于肌肉收缩、记忆形成和心率调节至关重要。 在神经系统的背景下，cholinergic神经元在突触处释放乙酰胆碱，然后与后突触神经元上的特定受体结合，从而导致各种反应。乙酰胆碱有两种主要类型的受体：烟碱型和毒蕈碱型受体。烟碱型受体位于神经肌肉接头，负责刺激肌肉收缩，而毒蕈碱型受体则存在于各种器官和组织中，影响心率和腺体分泌等功能。 对cholinergic系统的研究对理解某些疾病具有重要意义。例如，阿尔茨海默病与cholinergic活性的下降有关，导致认知缺陷。旨在增强cholinergic功能的疗法已被开发出来，以帮助减轻与这种情况相关的一些症状。这些治疗通常涉及使用乙酰胆碱酯酶抑制剂，这些药物可以防止乙酰胆碱的分解，从而增加其在大脑中的可用性。 此外，cholinergic机制的角色不仅限于神经退行性疾病。诸如重症肌无力等疾病，其中免疫系统攻击cholinergic受体，表明这一系统的干扰可能导致严重的肌肉无力。理解这些机制有助于开发针对性的疗法，从而改善患者的结果。 在药理学领域，各种药物与cholinergic系统相互作用。例如，一些用于治疗抑郁症或焦虑症的药物可能会影响cholinergic传输，突显神经递质系统在调节情绪和行为方面的相互联系。此外，使用抗胆碱药物（阻断乙酰胆碱作用的药物）可能会导致口干、便秘和混乱等副作用，强调了维持体内平衡时cholinergic活动的重要性。 总之，cholinergic的概念对于理解神经系统及其功能的复杂性至关重要。从肌肉控制到认知过程，乙酰胆碱及其相关通路在我们日常生活中发挥着重要作用。随着研究的不断深入，针对cholinergic系统的治疗干预潜力为改善各种神经和心理疾病的健康结果提供了令人兴奋的机会。通过更深入地探讨cholinergic信号传导的领域，我们可以更好地欣赏支配我们身体功能和对环境反应的神经递质之间复杂的平衡。