dystrophin

简明释义

英[ˈdɪstrəfɪn]美[dɪsˈtroʊfɪn]

n. 肌营养不良蛋白；抗肌萎缩蛋白

英英释义

单词用法

同义词

反义词

例句

1.DMD is the most common of nine types of muscular dystrophy, which is characterized by a lack of the protein dystrophin in voluntary muscles, such as those in the arms and legs.

DMD是九种肌营养不良症的最常见类型，以缺少四肢等随意肌的肌营养不良蛋白为主要特征。

2.DMD is the most common of nine types of muscular dystrophy, which is characterized by a lack of the protein dystrophin in voluntary muscles, such as those in the arms and legs.

DMD是九种肌营养不良症的最常见类型，以缺少四肢等随意肌的肌营养不良蛋白为主要特征。

3.The patients from 5 DMD and 2 BMD were detected by immunofluorescence technique for analyzing dystrophin located in muscle cell membrane, compared with 2 normal males.

并采用免疫荧光抗体染色技术对5例dmd,2例BMD肌细胞膜上抗肌营养不良蛋白的表达观察分析，以2例正常人的肌组织作为对照。

4.In these trials, dystrophin-positive fibres were accounted for by transcriptional (revertant) variants of the mutant dystrophin transcript.

在这些试验中，营养不良素阳性的肌纤维是由营养不良素转录体的突变引起的。

5.This new research modified the introduced dystrophin gene to increase the efficiency of dystrophin protein production in the cells.

这一新的经过改造的方法，增强了抗肌萎缩蛋白在肌肉细胞内产生的有效性。

6.Wu et al, Effective rescue of dystrophin improves cardiac function in dystrophin-deficient mice by a modified morpholino oligomer.

吴等人，有效的抗肌萎缩蛋白拯救提高了修改吗啉齐聚心功能的抗肌萎缩缺陷小鼠。

7.It is important to note, however, that different mutations in the dystrophin gene could require different oligonucleotide drugs.

重要的是要注意，不过，在不同的肌营养不良基因突变可能需要不同的寡核苷酸药物。

8.The dystrophin gene is found on the X chromosome and passed on to children through a mother who is a carrier.

肌营养不良卵白基因位于人类X染色体，携带基因突变的母亲会遗传给婴儿。

9.In the dystrophin gene, and in most of human genes, this genetic information is not contiguous.

在肌营养不良蛋白基因，在人类基因大多数，这种遗传信息不连续的。

10.The absence of dystrophin can lead to muscle degeneration.

缺乏dystrophin可能导致肌肉退化。

11.Researchers are studying how to restore dystrophin production in affected patients.

研究人员正在研究如何恢复受影响患者的dystrophin生产。

12.Gene therapy aims to correct the mutation that prevents dystrophin synthesis.

基因疗法旨在纠正阻止dystrophin合成的突变。

13.A lack of dystrophin is a hallmark of Duchenne muscular dystrophy.

缺乏dystrophin是杜氏肌营养不良症的特征。

14.Patients with a mutation in the dystrophin gene may experience progressive weakness.

携带dystrophin基因突变的患者可能会经历逐渐的虚弱。

作文

Dystrophin is a crucial protein found in skeletal and cardiac muscles, playing a vital role in maintaining the integrity of muscle fibers. It connects the internal cytoskeleton of muscle cells to the surrounding extracellular matrix, providing structural support and stability. The absence or malfunction of this protein leads to severe muscle disorders, most notably Duchenne Muscular Dystrophy (DMD). Individuals with DMD experience progressive muscle degeneration, which typically begins in early childhood and can lead to significant physical disability by the teenage years. Understanding the role of dystrophin (肌萎缩蛋白) is essential for developing effective treatments for these debilitating conditions. Research into dystrophin (肌萎缩蛋白) has advanced significantly over the years. Scientists have discovered that dystrophin (肌萎缩蛋白) is encoded by the DMD gene, which is located on the X chromosome. This genetic link explains why DMD predominantly affects males, as they have only one X chromosome. The mutations in the DMD gene can result in varying degrees of dystrophin (肌萎缩蛋白) deficiency, leading to different forms of muscular dystrophy. Some mutations may allow for the production of a partially functional version of dystrophin (肌萎缩蛋白), which can mitigate the severity of the disease. The significance of dystrophin (肌萎缩蛋白) extends beyond just muscular dystrophies. Its role in cellular signaling, mechanotransduction, and muscle regeneration highlights its importance in overall muscle health. Researchers are exploring gene therapy and other innovative approaches to restore or replace dystrophin (肌萎缩蛋白) function in affected individuals. These therapies aim to introduce a functional copy of the DMD gene or to bypass the faulty gene altogether. Clinical trials are ongoing, and some treatments have shown promise in improving muscle function and slowing disease progression. Moreover, the study of dystrophin (肌萎缩蛋白) has also opened avenues for understanding other muscle-related diseases. By investigating how dystrophin (肌萎缩蛋白) interacts with various cellular components, scientists are gaining insights into muscle repair mechanisms and potential therapeutic targets for a broader range of conditions. In conclusion, dystrophin (肌萎缩蛋白) is an essential protein that plays a pivotal role in muscle integrity and function. The implications of its absence are profound, leading to serious health challenges for those affected by related disorders. Ongoing research continues to unravel the complexities of dystrophin (肌萎缩蛋白) and its associated pathways, paving the way for new treatments and improved quality of life for individuals suffering from muscular dystrophies. As we deepen our understanding of dystrophin (肌萎缩蛋白), we move closer to finding effective solutions to combat these devastating diseases.

肌萎缩蛋白是存在于骨骼和心脏肌肉中的一种重要蛋白质，对于维持肌肉纤维的完整性起着至关重要的作用。它将肌肉细胞内部的细胞骨架与周围的细胞外基质连接起来，提供结构支持和稳定性。缺失或功能异常会导致严重的肌肉疾病，最明显的是杜氏肌营养不良症（DMD）。DMD患者经历渐进性的肌肉退化，通常在儿童早期开始，并可能在青少年时期导致显著的身体残疾。理解dystrophin（肌萎缩蛋白）的作用对于开发有效的治疗这些虚弱病症的方案至关重要。 多年来，对dystrophin（肌萎缩蛋白）的研究取得了显著进展。科学家发现，dystrophin（肌萎缩蛋白）是由位于X染色体上的DMD基因编码的。这一遗传联系解释了为什么DMD主要影响男性，因为他们只有一个X染色体。DMD基因中的突变可能导致不同程度的dystrophin（肌萎缩蛋白）缺乏，导致不同形式的肌营养不良症。有些突变可能允许产生部分功能的dystrophin（肌萎缩蛋白），这可以减轻疾病的严重性。 dystrophin（肌萎缩蛋白）的重要性不仅限于肌肉营养不良症。其在细胞信号传导、机械转导和肌肉再生中的作用突显了其在整体肌肉健康中的重要性。研究人员正在探索基因治疗和其他创新方法，以恢复或替代受影响个体的dystrophin（肌萎缩蛋白）功能。这些疗法旨在引入功能性DMD基因的拷贝，或绕过有缺陷的基因。临床试验正在进行中，一些治疗在改善肌肉功能和减缓疾病进展方面显示出了希望。 此外，对dystrophin（肌萎缩蛋白）的研究还为理解其他肌肉相关疾病开辟了途径。通过研究dystrophin（肌萎缩蛋白）如何与各种细胞成分相互作用，科学家们获得了对肌肉修复机制和潜在治疗靶点的见解。 总之，dystrophin（肌萎缩蛋白）是对肌肉完整性和功能至关重要的蛋白质。其缺失的影响深远，会给受相关疾病影响的人带来严重的健康挑战。持续的研究继续揭示dystrophin（肌萎缩蛋白）及其相关通路的复杂性，为新治疗方法和改善肌营养不良症患者生活质量铺平了道路。随着我们对dystrophin（肌萎缩蛋白）的理解加深，我们离找到有效解决这些毁灭性疾病的方案又近了一步。