autocrine

简明释义

英[/ˌɔːtəˈkraɪn/]美[/ˌɔːtəˈkraɪn/]

adj. 自分泌的，自泌的

英英释义

单词用法

同义词

反义词

例句

1.Depend on the role of proteins, target cells were stimulated differentiation by an autocrine or paracrine manner to promote osteogenesis.

依靠蛋白质的作用，靶细胞被刺激分化，通过自分泌或旁分泌的方式促进成骨。

2.Chinese Herbs may enhance expression of HB-EGF on trophoblast through autocrine and paracrine role, and may enhance proliferation, invasion and tolerance anoxia of trophoblast.

中药可能通过自分泌或旁分泌增加滋养细胞HB - EGF表达，增强滋养细胞的增殖及侵入和对缺氧的耐受。

3.Objective to investigate the relationship between activity of autocrine loop of platelet derived growth factor BB (PDGFBB), cell proliferation and apoptosis in gliomas.

目的探讨胶质瘤细胞血小板源生长因子B链的纯合二聚体(PDGFBB)自分泌环活性与其细胞增殖和凋亡的关系。

4.Objective to explore the regulatory, effect and mechanism of Ningxin Hongqi Capsule on local ovarian autocrine and paracrine factors in peri-menopausal rats.

目的探讨宁心红杞胶囊对围绝经大鼠卵巢局部自分泌及旁分泌因子的调节作用。

5.For example exosomes produced by pancreatic tumor cell lines had an autocrine effect on themselves shown by in vitro experiments [10].

例如，在体外实验中，由胰腺肿瘤细胞系产生的外泌体具有自分泌作用可作用于自身身[10]。

6.Cytokines are polypeptides, and mediate cellular responses through autocrine and paracrine.

细胞因子是一类小分子多肽，通过自分泌和旁分泌传递细胞应答。

7.Chinese Herbs may enhance expression of HB-EGF on trophoblast through autocrine and paracrine role, and may enhance proliferation, invasion and tolerance anoxia of trophoblast.

中药可能通过自分泌或旁分泌增加滋养细胞HB - EGF表达，增强滋养细胞的增殖及侵入和对缺氧的耐受。

8.It was concluded that Tpo may be a possible autocrine factor of HEL cells.

实验结论提示Tpo可能是HEL细胞的自分泌因子。

9.The immune cells often use autocrine signaling to enhance their own activation.

免疫细胞通常利用自分泌信号来增强自身的激活。

10.In cancer research, understanding autocrine mechanisms can reveal how tumors grow.

在癌症研究中，理解自分泌机制可以揭示肿瘤如何生长。

11.Certain hormones act in an autocrine manner, affecting the same cells that release them.

某些激素以自分泌的方式作用，影响释放它们的同一细胞。

12.The role of autocrine factors in cell proliferation is a key area of study in developmental biology.

在细胞增殖中，自分泌因子的作用是发育生物学研究的一个关键领域。

13.Research has shown that autocrine signaling can lead to resistance in cancer therapies.

研究表明，自分泌信号可能导致癌症治疗中的耐药性。

作文

In the realm of cellular communication, the term autocrine refers to a specific type of signaling where a cell produces a signal that binds to receptors on its own surface, thereby influencing its own behavior. This mechanism is crucial in various biological processes, including growth, development, and immune responses. Understanding the concept of autocrine signaling can provide significant insights into how cells interact with their environment and regulate their functions. The autocrine signaling pathway is often contrasted with other types of signaling mechanisms, such as paracrine and endocrine signaling. While paracrine signaling involves the release of signals that affect nearby cells, and endocrine signaling entails hormones traveling through the bloodstream to distant targets, autocrine signaling is unique in that it is self-directed. For instance, certain immune cells, like T cells, utilize autocrine signaling to amplify their own activation. When an antigen is presented, these cells secrete cytokines that bind to their own receptors, creating a feedback loop that enhances their response. This self-regulatory mechanism is particularly important in maintaining homeostasis within tissues. In situations where cells are under stress or facing pathogen challenges, autocrine signaling allows for rapid adjustments in cellular activity. For example, during inflammation, macrophages can produce pro-inflammatory cytokines that act on themselves to increase their phagocytic activity and promote healing processes. Moreover, autocrine signaling plays a pivotal role in cancer biology. Tumor cells often exploit this mechanism to sustain their growth and survival. By producing growth factors that act on their own receptors, cancer cells can create an environment that favors their proliferation and resistance to apoptosis. This understanding has led to the development of targeted therapies aimed at disrupting autocrine signaling pathways in tumors, highlighting the clinical significance of this form of communication. In conclusion, the concept of autocrine signaling is vital for understanding how cells communicate and regulate their functions. It illustrates the complexity of cellular interactions and the importance of self-regulation in various physiological and pathological processes. As research continues to uncover the intricacies of autocrine signaling, it is likely that new therapeutic strategies will emerge to manipulate these pathways for better health outcomes. By focusing on the mechanisms of autocrine signaling, scientists can pave the way for innovative treatments that target diseases at their cellular roots.

在细胞通信的领域中，术语自分泌指的是一种特定类型的信号传递，其中细胞产生的信号与其自身表面的受体结合，从而影响其自身行为。这种机制在包括生长、发育和免疫反应等各种生物过程中至关重要。理解自分泌信号传递的概念可以为我们提供重要的见解，了解细胞如何与其环境相互作用并调节其功能。 自分泌信号通路常常与其他类型的信号传递机制进行对比，例如旁分泌和内分泌信号传递。虽然旁分泌信号传递涉及到释放信号影响附近细胞，而内分泌信号传递则是激素通过血液循环到达远处靶标，但自分泌信号传递的独特之处在于它是自我导向的。例如，某些免疫细胞，如T细胞，利用自分泌信号传递来增强自身的激活。当抗原被呈现时，这些细胞分泌细胞因子，作用于自身的受体，形成一个反馈回路，从而增强它们的反应。 这种自我调节机制在维持组织的稳态中尤为重要。在细胞面临压力或病原挑战的情况下，自分泌信号传递允许细胞活动的快速调整。例如，在炎症过程中，巨噬细胞可以产生促炎细胞因子，这些因子作用于自身以增加其吞噬活性并促进愈合过程。 此外，自分泌信号传递在癌症生物学中发挥着关键作用。肿瘤细胞通常利用这一机制来维持其生长和存活。通过产生作用于自身受体的生长因子，癌细胞可以创造有利于其增殖和抵抗凋亡的环境。对这一现象的理解导致了旨在破坏肿瘤中自分泌信号通路的靶向治疗的发展，突显了这种通信形式的临床重要性。 总之，自分泌信号传递的概念对于理解细胞如何沟通和调节其功能至关重要。它展示了细胞间相互作用的复杂性以及自我调节在各种生理和病理过程中的重要性。随着研究不断揭示自分泌信号传递的复杂性，新的治疗策略可能会出现，以操控这些通路以获得更好的健康结果。通过关注自分泌信号传递的机制，科学家们可以为针对疾病根源的创新治疗铺平道路。