azathioprine

简明释义

英[ˌæzəˈθaɪəpriːn]美[ˌæzəˈθaɪəˌprin]

n. 咪唑硫嘌呤（一种免疫抑制药）

英英释义

单词用法

同义词

反义词

例句

1.Immunosuppressants When the condition is difficult to control or it is difficult to reduce your oral steroid dose without relapse, an immunosuppressant such as azathioprine or mercaptopurine is used.

免疫抑制剂时的条件是难以控制或是很困难的，以减少您的口服类固醇剂量，没有复发，免疫抑制剂，如硫唑嘌呤或巯基嘌呤是使用。

2.Background the comparative efficacy and safety of infliximab and azathioprine therapy alone or in combination for Crohn's disease are unknown.

背景在克罗恩病患者中，英夫利西单抗和硫唑嘌呤单药治疗或联合治疗的相对疗效和安全性尚未被了解。

3.This is seen in immunosuppressed patients usually on steroids, azathioprine, or cytotoxic agents following transplantation or for leukaemia or lymphoma.

在免疫受到抑制的病人可发生此病，患者因移植、白血病或淋巴瘤而常应用激素、硫唑嘌呤或细胞毒类药物治疗者。

4.Immunosuppressants When the condition is difficult to control or it is difficult to reduce your oral steroid dose without relapse, an immunosuppressant such as azathioprine or mercaptopurine is used.

免疫抑制剂时的条件是难以控制或是很困难的，以减少您的口服类固醇剂量，没有复发，免疫抑制剂，如硫唑嘌呤或巯基嘌呤是使用。

5.Among these patients, 69% achieved remission with the combination treatment compared to 57% of those on Remicade alone and to 28% of those on azathioprine alone.

这些病人中，通过联合治疗的有69%的人获得缓解而在英夫利昔单抗组中为57%，硫唑嘌呤组中只有28%的到缓解。

6.Conclusion Early adverse reaction is the main cause of azathioprine premature discontinuation in inflammatory bowel disease.

结论早期不良反应是引起炎性肠病患者停止硫唑嘌呤治疗的主要原因。

7.Agents such as sulfasalazine, corticosteroids, azathioprine, TNFa antagonists and thalidomide should be tried first before surgery, except in emergencies.

在进行手术前(除急诊外)，应尝试使用药物如柳氮磺吡啶、激素、硫唑嘌呤、肿瘤坏死因子拮抗剂及反应停。

8.The doctor prescribed azathioprine for my autoimmune condition.

医生为我的自身免疫疾病开了硫唑嘌呤。

9.After starting azathioprine, I noticed a significant improvement in my symptoms.

开始服用硫唑嘌呤后，我注意到我的症状有了显著改善。

10.Patients taking azathioprine should be monitored for liver function.

服用硫唑嘌呤的患者应该监测肝功能。

11.Side effects of azathioprine can include nausea and fatigue.

服用硫唑嘌呤的副作用可能包括恶心和疲劳。

12.My rheumatologist recommended azathioprine as a long-term treatment option.

我的风湿病专家推荐将硫唑嘌呤作为长期治疗方案。

作文

Azathioprine is a medication that has been widely used in the treatment of various autoimmune diseases and for organ transplantation. This drug works as an immunosuppressant, meaning it suppresses the immune system to prevent it from attacking the body’s own tissues or rejecting transplanted organs. The use of azathioprine (阿扎胞苷) dates back to the 1960s, and since then, it has become an essential part of therapy for conditions such as rheumatoid arthritis, lupus, and inflammatory bowel disease. The mechanism of action of azathioprine (阿扎胞苷) involves the inhibition of purine synthesis, which is crucial for the proliferation of lymphocytes, the white blood cells responsible for immune responses. By interfering with the production of these cells, azathioprine (阿扎胞苷) effectively reduces inflammation and helps to control the symptoms of autoimmune disorders. This makes it a vital option for patients who suffer from chronic conditions where the immune system is overactive. One of the most significant advantages of azathioprine (阿扎胞苷) is its ability to provide long-term relief for patients. Unlike some other treatments that may only offer short-term benefits, azathioprine (阿扎胞苷) can be taken for extended periods, allowing patients to manage their conditions more effectively. However, this long-term use comes with potential risks, including an increased susceptibility to infections and certain types of cancer due to the suppression of the immune system. Patients prescribed azathioprine (阿扎胞苷) must be closely monitored by healthcare professionals. Regular blood tests are necessary to ensure that liver function remains stable and to check for any signs of bone marrow suppression. It is also essential for patients to report any unusual symptoms promptly, as early detection of side effects can lead to better management and outcomes. In addition to its use in autoimmune diseases, azathioprine (阿扎胞苷) plays a critical role in organ transplantation. After a transplant, the body’s immune system may recognize the new organ as foreign and attempt to reject it. By using azathioprine (阿扎胞苷) in combination with other immunosuppressive agents, doctors can help prevent this rejection and improve the chances of a successful transplant. Despite its benefits, the use of azathioprine (阿扎胞苷) is not without challenges. Some patients may experience side effects, such as gastrointestinal disturbances, fatigue, and skin rashes. In rare cases, more severe complications can occur, which necessitates a reevaluation of the treatment plan. As with any medication, the risks and benefits must be carefully weighed by both the patient and the physician. In conclusion, azathioprine (阿扎胞苷) is a powerful tool in the management of autoimmune diseases and in the field of organ transplantation. Its ability to modulate the immune response makes it invaluable for many patients. However, careful monitoring and management are essential to minimize risks and ensure the best possible outcomes. As research continues, we may find new applications for azathioprine (阿扎胞苷) and further enhance our understanding of its role in medicine.

阿扎胞苷是一种广泛用于治疗各种自身免疫性疾病和器官移植的药物。该药物作为一种免疫抑制剂，意味着它抑制免疫系统，以防止其攻击身体自身的组织或拒绝移植的器官。azathioprine（阿扎胞苷）的使用可以追溯到20世纪60年代，从那时起，它已成为类风湿关节炎、狼疮和炎症性肠病等疾病治疗的重要组成部分。 azathioprine（阿扎胞苷）的作用机制涉及对嘌呤合成的抑制，这对于淋巴细胞的增殖至关重要，而淋巴细胞是负责免疫反应的白血球。通过干扰这些细胞的产生，azathioprine（阿扎胞苷）有效减少炎症，有助于控制自身免疫疾病的症状。这使得它成为慢性过度活跃免疫系统患者的重要选择。 azathioprine（阿扎胞苷）最显著的优势之一是其为患者提供长期缓解的能力。与其他可能仅提供短期益处的治疗方法不同，azathioprine（阿扎胞苷）可以长期服用，使患者能够更有效地管理其病情。然而，这种长期使用伴随着潜在风险，包括因免疫系统抑制而增加感染和某些类型癌症的易感性。 被开处方使用azathioprine（阿扎胞苷）的患者必须由医疗专业人员密切监测。定期的血液检查是必要的，以确保肝功能保持稳定，并检查骨髓抑制的任何迹象。患者还需及时报告任何异常症状，因为早期发现副作用可以导致更好的管理和结果。 除了在自身免疫疾病中的应用外，azathioprine（阿扎胞苷）在器官移植中也发挥着关键作用。移植后，身体的免疫系统可能会将新器官视为外来物并试图拒绝它。通过将azathioprine（阿扎胞苷）与其他免疫抑制剂联合使用，医生可以帮助防止这种排斥，提高成功移植的机会。 尽管有其好处，使用azathioprine（阿扎胞苷）并非没有挑战。一些患者可能会经历副作用，如胃肠道不适、疲劳和皮疹。在少数情况下，可能会出现更严重的并发症，这需要重新评估治疗方案。与任何药物一样，风险和收益必须由患者和医生仔细权衡。 总之，azathioprine（阿扎胞苷）是管理自身免疫疾病和器官移植领域的一种强大工具。其调节免疫反应的能力使其对许多患者来说不可或缺。然而，仔细的监测和管理对于最大限度地降低风险并确保最佳结果至关重要。随着研究的持续，我们可能会发现azathioprine（阿扎胞苷）的新应用，并进一步增强我们对其在医学中作用的理解。