azole

简明释义

英[əˈzəʊl]美[ˈæzˌol;ˈeˌzol]

n. [有化] 唑；一氮二烯伍圜；氮杂茂

英英释义

单词用法

同义词

反义词

例句

1.We present here the crystal structure of Mycobacterium tuberculosis cytochrome P450 CYP121 in complex with the triazole drug fluconazole, revealing a new azole heme ligation mode.

我们提出了肺结核分支杆菌细胞色素P 450CYP121与三氮唑类药物氟康唑的复合物的晶体结构，揭示了唑类与亚铁血红素新的结合模式。

2.Azole and triazole drugs are cytochrome P450 inhibitors widely used as fungal antibiotics and possessing potent antimycobacterial activity.

唑类和三氮唑类药物作为细胞色素P 450抑制剂广泛被作为抗真菌药物和抗微生物药物使用。

3.The azole antifungals, widely prescribed prophylactically, are known to have many drug2013drug interactions.

处方中经常使用的三唑类抗真菌制剂已知有许多药物相互作用。

4.Management of breakthrough invasive aspergillosis in the context of mould-active azole prophylaxis is not defined by clinical trial data.

在现行的唑类药物预防的模式背景下，没有通过临床实验资料定义侵袭性曲菌病的突破性治疗。

5.It is an object of the present invention to provide a pharmaceutical composition containing a stable azole-based compound, which is useful as an antifungal agent.

本发明提供一种含有作为抗真菌药有用且稳定的吡咯类化合物的药物组合物。

6.We present here the crystal structure of Mycobacterium tuberculosis cytochrome P450 CYP121 in complex with the triazole drug fluconazole, revealing a new azole heme ligation mode.

我们提出了肺结核分支杆菌细胞色素P 450CYP121与三氮唑类药物氟康唑的复合物的晶体结构，揭示了唑类与亚铁血红素新的结合模式。

7.Conventional diagnosis of aspergillosis is limited by poor culture yield, and so the true frequency of azole resistance has been unclear.

常规曲霉病诊断方法由于培养能力限制，不能准确测定对唑类药物的耐药水平。

8.The doctor prescribed an antifungal medication containing azole to treat the patient's infection.

医生开了一种含有azole的抗真菌药物来治疗患者的感染。

9.Many azole-based drugs are used in agriculture to prevent fungal diseases in crops.

许多基于azole的药物被用于农业，以防止作物中的真菌病害。

10.The research focused on the effectiveness of azole compounds against various fungal strains.

研究集中在azole化合物对各种真菌菌株的有效性上。

11.A common side effect of azole medications is gastrointestinal discomfort.

一种常见的azole药物副作用是胃肠不适。

12.Patients should inform their doctors about any allergies to azole drugs.

患者应告知医生是否对azole药物过敏。

作文

The term azole refers to a class of compounds that are characterized by a five-membered ring containing at least one nitrogen atom. These compounds play a significant role in various fields, particularly in medicine and agriculture. In the realm of pharmaceuticals, azole derivatives are widely used as antifungal agents. They work by inhibiting the synthesis of ergosterol, an essential component of fungal cell membranes, thereby disrupting their integrity and leading to cell death. This mechanism makes azole antifungals effective against a variety of fungal infections, including those caused by Candida and Aspergillus species. In addition to their medicinal applications, azole compounds are also utilized in agricultural settings. Certain azole fungicides are employed to protect crops from fungal diseases, thus ensuring better yields and quality of produce. These fungicides are particularly important in the management of plant diseases, as they help to prevent significant losses that can occur due to fungal infections. The use of azole fungicides has become increasingly common in modern agriculture, promoting sustainable practices while minimizing the impact of pests and diseases on food production. Despite their benefits, there are concerns regarding the potential for resistance development in both fungi and bacteria. Overuse of azole antifungals in clinical settings can lead to the emergence of resistant strains, making it more challenging to treat infections. Similarly, the application of azole fungicides in agriculture can contribute to resistance in plant pathogens, necessitating the need for integrated pest management strategies that combine chemical and non-chemical methods. Moreover, the environmental impact of azole compounds cannot be overlooked. Studies have shown that some azole fungicides can persist in the environment and may affect non-target organisms, including beneficial insects and soil microorganisms. Therefore, it is crucial for researchers and practitioners to carefully consider the use of azole compounds and to explore alternative methods that can mitigate their environmental footprint. In conclusion, the term azole encompasses a diverse group of compounds with significant implications in medicine and agriculture. Their effectiveness as antifungal agents and fungicides highlights their importance in combating fungal infections and protecting crops. However, the challenges associated with resistance development and environmental impact underscore the need for responsible usage and ongoing research into safer alternatives. As we continue to explore the potential of azole compounds, it is essential to balance their benefits with the need for sustainable practices that protect both human health and the environment.

术语azole指的是一类化合物，其特征是含有至少一个氮原子的五元环。这些化合物在多个领域中发挥着重要作用，尤其是在医学和农业中。在制药领域，azole衍生物被广泛用作抗真菌剂。它们通过抑制麦角甾醇的合成来发挥作用，麦角甾醇是真菌细胞膜的重要组成部分，从而破坏其完整性并导致细胞死亡。这一机制使得azole抗真菌药物对多种真菌感染有效，包括由念珠菌和曲霉菌引起的感染。 除了药用应用外，azole化合物还被用于农业领域。某些azole杀真菌剂被用于保护农作物免受真菌病害，从而确保更好的产量和产品质量。这些杀真菌剂在植物病害管理中尤为重要，因为它们有助于防止由于真菌感染而导致的重大损失。现代农业中越来越普遍使用azole杀真菌剂，促进可持续实践，同时将害虫和疾病对粮食生产的影响降到最低。 尽管有其好处，但人们对真菌和细菌可能产生的耐药性发展表示担忧。在临床环境中滥用azole抗真菌药物可能导致耐药菌株的出现，使感染治疗变得更加困难。同样，在农业中应用azole杀真菌剂也可能促成植物病原体的耐药性，因此需要整合害虫管理策略，结合化学和非化学方法。 此外，azole化合物对环境的影响也不容忽视。研究表明，一些azole杀真菌剂可能在环境中持久存在，并可能影响非目标生物，包括有益昆虫和土壤微生物。因此，研究人员和从业者必须仔细考虑azole化合物的使用，并探索可以减轻其环境足迹的替代方法。 总之，术语azole涵盖了一组具有重要意义的化合物，在医学和农业中具有重要影响。作为抗真菌剂和杀真菌剂的有效性突显了它们在抵御真菌感染和保护农作物方面的重要性。然而，与耐药性发展和环境影响相关的挑战突显了负责任使用和持续研究更安全替代品的必要性。当我们继续探索azole化合物的潜力时，平衡其益处与保护人类健康和环境的可持续实践的需求至关重要。