busulfan

简明释义

英[bjuːˈsʌlfæn]美[bjuːˈsʌlfən]

n. [药] 白消安；二甲磺酸丁酯

英英释义

单词用法

同义词

反义词

例句

1.CONCLUSION the method is sensitive and accurate for the determination of busulfan concentration in human plasma. It is suitable for the pharmacokinetics study of busulfan.

结论：该方法准确、灵敏，适用于白消安血浆浓度测定及其药动学研究。

2.CONCLUSION the method is sensitive and accurate for the determination of busulfan concentration in human plasma. It is suitable for the pharmacokinetics study of busulfan.

结论：该方法准确、灵敏，适用于白消安血浆浓度测定及其药动学研究。

3.The doctor prescribed busulfan for the patient's conditioning regimen before a stem cell transplant.

医生为患者在干细胞移植前的预处理方案中开了氟尿嘧啶。

4.Patients receiving busulfan must be monitored for potential liver toxicity.

接受氟尿嘧啶治疗的患者必须监测可能的肝毒性。

5.The use of busulfan in chemotherapy can lead to a decrease in white blood cell count.

在化疗中使用氟尿嘧啶可能导致白细胞计数下降。

6.Before starting busulfan, the healthcare team discussed the possible side effects with the patient.

在开始使用氟尿嘧啶之前，医疗团队与患者讨论了可能的副作用。

7.The pharmacokinetics of busulfan can vary significantly between patients.

不同患者之间的氟尿嘧啶药代动力学可能有显著差异。

作文

Busulfan is a chemotherapy medication primarily used in the treatment of certain types of cancers, particularly chronic myeloid leukemia (CML). This drug belongs to a class of medications known as alkylating agents, which work by interfering with the DNA in cancer cells, preventing them from dividing and growing. The history of busulfan (布苏芬) dates back to the 1950s when it was first synthesized and later approved for clinical use. Since then, it has played a crucial role in the management of hematological malignancies. The mechanism of action of busulfan (布苏芬) involves the formation of cross-links in the DNA strands of cancer cells. This cross-linking prevents the normal replication of DNA, leading to cell death. One of the significant advantages of busulfan (布苏芬) is its ability to target rapidly dividing cells, which is a characteristic of many cancer types. However, this also means that it can affect healthy cells that divide quickly, such as those in the bone marrow, gastrointestinal tract, and hair follicles, leading to various side effects. Patients receiving busulfan (布苏芬) may experience side effects such as nausea, vomiting, hair loss, and an increased risk of infections due to decreased white blood cell counts. It is essential for healthcare providers to monitor patients closely during treatment to manage these side effects effectively. In some cases, busulfan (布苏芬) is used in combination with other chemotherapy agents to enhance its efficacy and improve patient outcomes. In recent years, researchers have been exploring ways to optimize the use of busulfan (布苏芬) in clinical settings. One area of focus has been on personalized medicine, where the dosage of busulfan (布苏芬) is tailored based on the patient's individual characteristics, such as genetic factors and overall health. This approach aims to maximize the drug's effectiveness while minimizing adverse effects, making treatment safer and more tolerable for patients. Another exciting development in the field is the investigation of busulfan (布苏芬) as part of conditioning regimens before stem cell transplants. In this context, busulfan (布苏芬) is used to prepare the patient’s body to receive transplanted stem cells by eradicating the existing bone marrow and creating space for the new cells. This application has shown promising results in improving transplant outcomes and reducing the risk of relapse in certain cancers. Despite its benefits, the use of busulfan (布苏芬) is not without risks. Long-term exposure to this medication has been associated with secondary malignancies, particularly in patients who have received high doses or prolonged treatment. Therefore, it is crucial for oncologists to weigh the potential benefits against the risks when considering busulfan (布苏芬) as part of a treatment plan. In conclusion, busulfan (布苏芬) remains a vital component in the arsenal against certain cancers, particularly CML. Its unique mechanism of action and ability to target rapidly dividing cells make it an effective treatment option. However, careful monitoring and personalized approaches are essential to ensure patient safety and optimize treatment outcomes. As research continues to advance, the future of busulfan (布苏芬) in oncology looks promising, with the potential for improved therapies that can enhance the quality of life for patients battling cancer.

布苏芬是一种化疗药物，主要用于治疗某些类型的癌症，特别是慢性髓性白血病（CML）。该药物属于烷基化剂类药物，通过干扰癌细胞中的DNA，阻止它们分裂和生长，从而发挥作用。布苏芬的历史可以追溯到20世纪50年代，当时首次合成并随后获得临床使用批准。从那时起，它在血液恶性肿瘤的管理中发挥了至关重要的作用。 布苏芬的作用机制涉及在癌细胞DNA链中形成交联。这种交联阻止了DNA的正常复制，导致细胞死亡。布苏芬的一个显著优点是能够靶向快速分裂的细胞，这正是许多癌症类型的特征。然而，这也意味着它可能会影响那些快速分裂的健康细胞，例如骨髓、胃肠道和毛囊中的细胞，从而导致各种副作用。 接受布苏芬治疗的患者可能会经历如恶心、呕吐、脱发以及由于白细胞计数降低而增加感染风险等副作用。因此，医疗提供者在治疗期间密切监测患者，以有效管理这些副作用。在某些情况下，布苏芬与其他化疗药物联合使用，以增强其疗效并改善患者的预后。 近年来，研究人员一直在探索优化布苏芬在临床应用中的使用方法。一个关注领域是个性化医学，根据患者的个体特征，如遗传因素和整体健康状况，量身定制布苏芬的剂量。这种方法旨在最大限度地提高药物的有效性，同时减少不良反应，使治疗对患者更安全、更可耐受。 另一个令人兴奋的发展是在干细胞移植前的条件处理方案中研究布苏芬。在这种情况下，布苏芬用于准备患者的身体以接受移植的干细胞，通过消除现有的骨髓并为新细胞创造空间。这个应用在改善移植结果和降低某些癌症复发风险方面显示出良好的前景。 尽管有其好处，使用布苏芬并非没有风险。长期使用这种药物与继发性恶性肿瘤相关，特别是在接受高剂量或长期治疗的患者中。因此，肿瘤科医生在考虑将布苏芬纳入治疗计划时，必须权衡潜在的益处与风险。 总之，布苏芬仍然是对抗某些癌症，特别是CML的重要组成部分。其独特的作用机制和靶向快速分裂细胞的能力使其成为有效的治疗选择。然而，仔细监测和个性化的方法对于确保患者安全和优化治疗结果至关重要。随着研究的不断进展，布苏芬在肿瘤学中的未来看起来充满希望，有可能改善治疗，提高癌症患者的生活质量。