calpain

简明释义

英[ˈkælpeɪn]美[ˈkælpən]

钙蛋白酶

英英释义

单词用法

同义词

反义词

例句

1.Methods The model of focal cerebral ischemia reperfusion in rat was established. The activity of calpain was measured dynamically by biochemical methods.

方法采用大鼠局灶脑缺血模型，观察辛伐他汀抗大鼠脑缺血再灌注损伤作用及钙蛋白酶活性的变化。

2.Methods The model of focal cerebral ischemia reperfusion in rat was established. The activity of calpain was measured dynamically by biochemical methods.

方法采用大鼠局灶脑缺血模型，观察辛伐他汀抗大鼠脑缺血再灌注损伤作用及钙蛋白酶活性的变化。

3.The main content of this paper were: the structure of calpain, factors affecting activities, contribution to meat tenderness.

本文主要论述了钙激活酶的分子结构特征，影响酶活性的因素、以及对肌肉嫩化的作用机理等方面的内容。

4.The family members, the structure and functions of calpain system were reviewed.

本文主要就其成员、结构、功能等方面作一综述。

5.The role of calpain in muscle protein degradation is critical for understanding muscle wasting diseases.

在肌肉蛋白降解中，calpain的作用对于理解肌肉消耗疾病至关重要。

6.Researchers are studying how calpain can be inhibited to prevent cell death in neurodegenerative diseases.

研究人员正在研究如何抑制calpain以防止神经退行性疾病中的细胞死亡。

7.In the context of cancer, calpain may contribute to tumor progression by altering cell adhesion.

在癌症的背景下，calpain可能通过改变细胞粘附来促进肿瘤进展。

8.The activation of calpain has been linked to the inflammatory response in various tissues.

calpain的激活与多种组织中的炎症反应有关。

9.Scientists have developed specific inhibitors targeting calpain to explore therapeutic options for heart diseases.

科学家们开发了针对calpain的特定抑制剂，以探索心脏病的治疗选择。

作文

Calpain is a type of enzyme that plays a crucial role in various cellular processes. It belongs to a family of calcium-dependent cysteine proteases, which means it requires calcium ions to function effectively. The discovery of calpain has opened up new avenues in the fields of biochemistry and molecular biology, as it is involved in a wide range of physiological functions, including cell motility, proliferation, and apoptosis. Understanding the mechanisms by which calpain operates can provide insights into numerous diseases, such as cancer, neurodegenerative disorders, and muscular dystrophies. In recent years, researchers have focused on the role of calpain in cellular signaling pathways. One of the key aspects of calpain activity is its ability to cleave specific proteins, thereby modulating their function. For instance, calpain can activate or deactivate proteins involved in the cell cycle, influencing how cells grow and divide. This regulation is particularly important in cancer research, where uncontrolled cell division is a hallmark of tumor development. Moreover, calpain is implicated in the process of apoptosis, or programmed cell death. By cleaving certain substrates, calpain can either promote or inhibit apoptosis, depending on the context. This dual role makes calpain a potential target for therapeutic interventions. For example, inhibiting calpain activity could help prevent unwanted cell death in neurodegenerative diseases, while promoting its activity might be beneficial in eliminating cancer cells. Another interesting aspect of calpain is its involvement in muscle physiology. In skeletal muscle, calpain is activated during contraction and is believed to play a role in muscle remodeling and repair. This has led to investigations into how calpain might be manipulated to enhance muscle recovery after injury or to improve performance in athletes. Understanding the precise functions of calpain in muscle tissue could lead to innovative treatments for muscle-related conditions. Despite the progress made in understanding calpain, many questions remain unanswered. Researchers are still exploring the full range of substrates that calpain targets and the consequences of these interactions. Additionally, the regulation of calpain activity itself is a complex area of study, with various factors influencing its activation and inhibition. In conclusion, calpain is a vital enzyme with diverse roles in cellular processes. Its importance in health and disease makes it a significant subject of study in modern biology. As we continue to unravel the complexities of calpain and its functions, we may uncover new strategies for treating diseases and improving human health. The ongoing research surrounding calpain not only enhances our understanding of fundamental biological processes but also holds promise for developing novel therapeutic approaches to tackle various health challenges.

calpain是一种酶，在各种细胞过程中发挥着至关重要的作用。它属于钙依赖性半胱氨酸蛋白酶家族，这意味着它需要钙离子才能有效地发挥功能。calpain的发现为生物化学和分子生物学领域开辟了新的途径，因为它参与了许多生理功能，包括细胞运动、增殖和凋亡。理解calpain的作用机制可以提供对许多疾病的见解，例如癌症、神经退行性疾病和肌肉萎缩。 近年来，研究人员专注于calpain在细胞信号通路中的作用。calpain活性的一个关键方面是它能够切割特定蛋白质，从而调节其功能。例如，calpain可以激活或失活参与细胞周期的蛋白质，影响细胞的生长和分裂。这种调节在癌症研究中尤为重要，因为不受控制的细胞分裂是肿瘤发展的标志。 此外，calpain还与凋亡或程序性细胞死亡的过程有关。通过切割某些底物，calpain可以根据上下文促进或抑制凋亡。这种双重角色使得calpain成为潜在的治疗干预目标。例如，抑制calpain活性可能有助于防止神经退行性疾病中不必要的细胞死亡，而促进其活性可能有利于消灭癌细胞。 calpain的另一个有趣方面是它在肌肉生理学中的作用。在骨骼肌中，calpain在收缩期间被激活，被认为在肌肉重塑和修复中发挥作用。这导致人们调查如何操控calpain以增强受伤后的肌肉恢复或提高运动员的表现。理解calpain在肌肉组织中的确切功能可能会导致创新的肌肉相关疾病治疗方法。 尽管在理解calpain方面取得了进展，但仍然有许多问题尚未解答。研究人员仍在探索calpain所靶向的所有底物及其相互作用的后果。此外，calpain活性的调节本身也是一个复杂的研究领域，各种因素影响其激活和抑制。 总之，calpain是一种在细胞过程中具有多样化角色的重要酶。它在健康和疾病中的重要性使其成为现代生物学研究的重要主题。随着我们继续揭示calpain及其功能的复杂性，我们可能会发现治疗疾病和改善人类健康的新策略。围绕calpain的持续研究不仅增强了我们对基本生物过程的理解，还为开发新型治疗方法应对各种健康挑战带来了希望。