carcinogenesis

简明释义

英[ˌkɑr.sɪ.nəˈdʒɛn.ɪ.sɪs]美[ˌkɑr.sɪ.nəˈdʒɛn.ɪ.sɪs]

n. [肿瘤] 致癌作用

复 数 c a r c i n o g e n e s e s

英英释义

单词用法

同义词

反义词

例句

1.In recent years, many naturally existing substances have been shown to possess protection against experimental carcinogenesis.

近年来，在实验中许多天然存在的物质表现出防癌作用。

2.They are all important in the carcinogenesis of hepatoma.

这些基因在肝癌的发病中可能起着非常重要的作用。

3.It is suggested that the overexpression of P53 protein may be an early event in carcinogenesis of the esophagus.

结果表明：P 53基因蛋白产物的高表达在食管癌的发生中是一个早期生物学标志。

4.Cell death is a gene-controlled form of programmed death, is closely related with oral mucosa carcinogenesis.

细胞凋亡是基因控制的程序性死亡，与口腔黏膜癌变密切相关。

5.He argues that the prevailing theories of carcinogenesis, or cancer formation, are wrong.

他还抨击之前的致癌机理或癌症形成过程的理论是错误的。

6.Considering the difference between parotid gland and oral cavity, carcinogenesis of HPV16, 18 is by synergistic action.

考虑到腮腺与口腔组织所处的环境差异，HPV16,18的致癌作用可能表现为协同效应。

7.Three-stage hypothesis of carcinogenesis pointed out that tumor promoter might play a key role in tumor development.

根据肿瘤发生的三阶段学说，肿瘤促进剂在肿瘤发生中也起到一定的关键性作用。

8.Chemical carcinogenesis is involved in complicated multiple stages of initiation, promotion and progression.

化学致癌过程是涉及启动、促进和进展等多阶段的复杂过程。

9.Research has shown that certain chemicals can accelerate carcinogenesis 癌症发生 in laboratory animals.

研究表明，某些化学物质可以加速实验动物中的carcinogenesis 癌症发生。

10.The study focused on the role of genetic mutations in carcinogenesis 癌症发生.

这项研究集中于基因突变在carcinogenesis 癌症发生中的作用。

11.Lifestyle choices, such as smoking, are known to contribute to carcinogenesis 癌症发生.

生活方式选择，如吸烟，已知会促进carcinogenesis 癌症发生。

12.Understanding the mechanisms of carcinogenesis 癌症发生 can lead to better prevention strategies.

了解carcinogenesis 癌症发生的机制可以导致更好的预防策略。

13.Certain viruses have been linked to carcinogenesis 癌症发生 in humans.

某些病毒与人类的carcinogenesis 癌症发生有关。

作文

Carcinogenesis is a complex process that involves the transformation of normal cells into cancerous cells. Understanding this process is crucial for developing effective prevention and treatment strategies for cancer. The term carcinogenesis (癌变) refers to the series of changes that cells undergo as they become malignant. This process can be triggered by various factors, including genetic mutations, environmental influences, and lifestyle choices. At the molecular level, carcinogenesis begins with the alteration of DNA, which may occur due to exposure to carcinogens such as tobacco smoke, radiation, or certain chemicals. These carcinogens can cause mutations in the genes that regulate cell growth and division, leading to uncontrolled proliferation of cells. Over time, these mutated cells can accumulate additional genetic changes, further promoting their malignant behavior. There are several stages in the process of carcinogenesis that researchers have identified. The first stage is initiation, where a normal cell undergoes a genetic change due to exposure to a carcinogenic agent. This stage is often irreversible and sets the foundation for the subsequent stages of cancer development. The second stage is promotion, where the initiated cell is stimulated to proliferate by various factors, such as hormones or inflammation. This stage can be reversible, meaning that removing the promoting factors may halt the progression toward cancer. The final stage is progression, where the promoted cells acquire additional mutations that enable them to invade surrounding tissues and metastasize to distant sites in the body. This stage is characterized by aggressive behavior and resistance to treatment, making it particularly challenging to manage clinically. Research into carcinogenesis has led to significant advancements in our understanding of cancer biology. For instance, scientists have discovered specific oncogenes and tumor suppressor genes that play critical roles in regulating cell growth and preventing cancer. Mutations in these genes can lead to the development of tumors. Furthermore, understanding the mechanisms behind carcinogenesis has paved the way for targeted therapies that aim to specifically inhibit the pathways involved in cancer progression. Preventing carcinogenesis is equally important as understanding its mechanisms. Public health initiatives focused on reducing exposure to known carcinogens, promoting healthy lifestyles, and encouraging regular screenings can significantly lower cancer incidence rates. For example, anti-smoking campaigns have been instrumental in reducing lung cancer rates, as tobacco is one of the most potent carcinogens. In conclusion, carcinogenesis is a multifaceted process that requires a comprehensive approach for prevention and treatment. By continuing to research the underlying mechanisms of carcinogenesis, we can develop better strategies to combat cancer and improve public health outcomes. Education about the risks associated with various carcinogens and promoting healthy lifestyle choices are essential components in the fight against cancer. As our understanding of carcinogenesis evolves, so too will our ability to prevent and treat this devastating disease.

癌变是一个复杂的过程，涉及正常细胞转变为癌细胞。理解这个过程对于开发有效的癌症预防和治疗策略至关重要。术语carcinogenesis（癌变）指的是细胞在变为恶性细胞时所经历的一系列变化。这个过程可以由多种因素引发，包括基因突变、环境影响和生活方式选择。 在分子水平上，carcinogenesis的开始是DNA的改变，这可能是由于接触致癌物质如烟草烟雾、辐射或某些化学物质而发生的。这些致癌物质可以导致调节细胞生长和分裂的基因发生突变，从而导致细胞的失控增殖。随着时间的推移，这些突变细胞可以积累额外的基因变化，进一步促进其恶性行为。 研究人员已确定了carcinogenesis过程中几个阶段。第一阶段是启动，在这一阶段，正常细胞由于接触致癌剂而经历基因变化。这个阶段通常是不可逆转的，并为癌症发展的后续阶段奠定基础。第二阶段是促进，在这一阶段，启动的细胞受到激素或炎症等各种因素的刺激而增殖。这个阶段是可逆的，意味着去除促进因素可能会阻止癌症的发展。 最后一个阶段是进展，在这一阶段，促进的细胞获得额外的突变，使它们能够侵入周围组织并转移到身体的远处部位。这个阶段的特征是攻击性行为和对治疗的抵抗，使其在临床管理中尤其具有挑战性。 对carcinogenesis的研究已导致我们对癌症生物学的理解取得显著进展。例如，科学家发现了特定的癌基因和肿瘤抑制基因，这些基因在调节细胞生长和预防癌症中起着关键作用。这些基因的突变可能导致肿瘤的发展。此外，理解carcinogenesis背后的机制为靶向疗法铺平了道路，这些疗法旨在特异性地抑制参与癌症进展的途径。 预防carcinogenesis与理解其机制同样重要。公共卫生倡议专注于减少对已知致癌物的暴露、促进健康生活方式和鼓励定期筛查，可以显著降低癌症发生率。例如，反吸烟运动在降低肺癌发生率方面发挥了重要作用，因为烟草是最强效的致癌物之一。 总之，carcinogenesis是一个多方面的过程，需要全面的方法来进行预防和治疗。通过继续研究carcinogenesis的基本机制，我们可以制定更好的策略来对抗癌症并改善公共健康结果。教育公众了解与各种致癌物相关的风险以及促进健康生活方式选择是与癌症作斗争的重要组成部分。随着我们对carcinogenesis的理解不断发展，我们对预防和治疗这种毁灭性疾病的能力也将不断提升。