cathepsin

简明释义

英[kəˈθepsɪn]美[kəˈθepsɪn]

n. [生化] 组织蛋白酶

英英释义

单词用法

同义词

反义词

例句

1.Aim to explore the effect of oxidized low density lipoprotein (ox LDL) on cholesterol accumulation in mouse peritoneal macrophages and its relationship with activity of lysosomal cathepsin.

研究氧化型低密度脂蛋白对小鼠腹腔巨噬细胞胆固醇蓄积的影响，并探讨其与组织蛋白酶活性之间的关系。

2.It's not yet clear whether measuring this chemical, cathepsin s, could help doctors predict risk of death or disease in individuals.

这种分子就是组织蛋白酶s，现在还不清楚它在血液中的指标能否用于预测病人的死亡率或者患病率。

3.Results C5 exposed to cathepsin G and elastase generated C5 fragments. C5 fragments stimulated primed neutrophil to release myeloperoxidase(MPO) and lactoferrin.

结果C5暴露于组织蛋白酶G和弹性酶时，产生C5片段，而C5片段能使活化的白细胞释放MPO和乳铁传递蛋白。

4.Objective To investigate the expression and the significance of cathepsin D(CD) and matrix metalloproteinase-9(MMP-9) in oral squamous cell carcinoma(OSCC).

目的探讨组织蛋白酶D（CD）与基质金属蛋白酶-9（MMP-9）在人类口腔鳞癌（OSCC）中的表达意义。

5.Expression of matrix metalloproteinase-8,11,19 and cathepsin B in abnormal placental tissues.

基质金属蛋白酶-8，11，19和组织蛋白酶B在异常胎盘绒毛组织中的表达。

6.Aim to explore the effect of oxidized low density lipoprotein (ox LDL) on cholesterol accumulation in mouse peritoneal macrophages and its relationship with activity of lysosomal cathepsin.

研究氧化型低密度脂蛋白对小鼠腹腔巨噬细胞胆固醇蓄积的影响，并探讨其与组织蛋白酶活性之间的关系。

7.Present review describes different events in cellular life of cathepsin d, mainly its biosynthesis and biological function.

本篇综述了蛋白酶d在细胞中的生物合成路线及其在细胞内的生物功能。

8.The enzyme cathepsin plays a crucial role in protein degradation within lysosomes.

酶cathepsin在溶酶体内的蛋白质降解中起着至关重要的作用。

9.Research has shown that cathepsin activity is linked to various diseases, including cancer.

研究表明，cathepsin活性与多种疾病有关，包括癌症。

10.Inhibiting cathepsin can potentially slow down the progression of certain neurodegenerative disorders.

抑制cathepsin可能会减缓某些神经退行性疾病的进展。

11.The study focused on how cathepsin contributes to the immune response during infection.

该研究集中于cathepsin如何在感染过程中促进免疫反应。

12.Elevated levels of cathepsin have been observed in patients with rheumatoid arthritis.

在类风湿性关节炎患者中观察到cathepsin水平升高。

作文

The study of enzymes has always been a fascinating topic in the field of biochemistry. One such enzyme that has garnered significant attention is cathepsin, a type of protease found in various tissues throughout the body. Understanding cathepsin and its functions can provide valuable insights into numerous biological processes, including protein degradation, immune response, and even the development of certain diseases. Cathepsin is primarily known for its role in breaking down proteins within lysosomes, which are cellular organelles responsible for waste disposal and recycling. This process is crucial for maintaining cellular health, as it helps to eliminate damaged or misfolded proteins that could otherwise accumulate and lead to cellular dysfunction. Research has shown that dysregulation of cathepsin activity can contribute to various pathological conditions, such as cancer, neurodegenerative diseases, and inflammatory disorders. One of the most interesting aspects of cathepsin is its involvement in the immune system. It plays a pivotal role in antigen processing, which is essential for the activation of T cells. When pathogens invade the body, cathepsin helps to degrade these foreign proteins into smaller peptides that can be presented on the surface of immune cells. This presentation is critical for the recognition and elimination of pathogens by the immune system. Consequently, understanding how cathepsin functions can aid in the development of immunotherapies and vaccines. Moreover, cathepsin has been implicated in the progression of various cancers. Studies have indicated that certain types of cathepsin are overexpressed in tumor tissues, promoting cancer cell invasion and metastasis. This has led researchers to explore the potential of targeting cathepsin as a therapeutic strategy. By inhibiting its activity, it may be possible to slow down or stop the spread of cancer, providing a new avenue for treatment. In addition to its roles in disease, cathepsin also has implications in normal physiological processes such as tissue remodeling and wound healing. During tissue repair, cathepsin aids in the breakdown of extracellular matrix components, allowing for the regeneration of damaged tissues. This function is particularly important in conditions where rapid healing is necessary, such as after surgery or injury. Despite the promising research surrounding cathepsin, there is still much to learn about its complex functions and regulatory mechanisms. Ongoing studies aim to uncover the precise roles of different cathepsin isoforms and their interactions with other cellular pathways. This knowledge could lead to novel therapeutic approaches that harness the power of cathepsin modulation in treating a variety of diseases. In conclusion, cathepsin is a crucial enzyme with diverse roles in both health and disease. Its involvement in protein degradation, immune response, and tissue remodeling highlights its significance in biological processes. As research continues to unravel the complexities of cathepsin, it holds great promise for advancing our understanding of cellular functions and developing innovative treatments for various medical conditions.

酶的研究一直是生物化学领域一个引人入胜的话题。其中一种受到广泛关注的酶是cathepsin，它是一种存在于身体各个组织中的蛋白酶。理解cathepsin及其功能可以为许多生物过程提供宝贵的见解，包括蛋白质降解、免疫反应，甚至某些疾病的发展。 Cathepsin主要以其在溶酶体内分解蛋白质的作用而闻名，这些细胞器负责废物处理和回收。这个过程对维持细胞健康至关重要，因为它有助于消除可能积累并导致细胞功能障碍的损坏或错误折叠的蛋白质。研究表明，cathepsin活性的失调可能会导致各种病理状况，例如癌症、神经退行性疾病和炎症性疾病。 Cathepsin最有趣的方面之一是它在免疫系统中的参与。它在抗原处理中的关键作用对于T细胞的激活至关重要。当病原体入侵身体时，cathepsin帮助将这些外源性蛋白质降解为可以在免疫细胞表面呈现的小肽。这种呈现对免疫系统识别和消灭病原体至关重要。因此，理解cathepsin的功能可以帮助开发免疫疗法和疫苗。 此外，cathepsin与各种癌症的进展有关。研究表明，某些类型的cathepsin在肿瘤组织中表达过高，促进癌细胞的侵袭和转移。这促使研究人员探索以cathepsin为靶点的治疗策略。通过抑制其活性，可能有可能减缓或阻止癌症的扩散，为治疗提供新的途径。 除了在疾病中的作用，cathepsin在正常生理过程中也具有重要意义，如组织重塑和伤口愈合。在组织修复过程中，cathepsin有助于分解细胞外基质成分，使受损组织得以再生。这一功能在需要快速愈合的情况下尤为重要，例如手术或受伤后。 尽管围绕cathepsin的研究前景广阔，但我们仍需了解其复杂的功能和调控机制。正在进行的研究旨在揭示不同cathepsin亚型的确切作用及其与其他细胞通路的相互作用。这些知识可能会导致新型治疗方法的出现，利用cathepsin调节的力量治疗各种疾病。 总之，cathepsin是一种在健康和疾病中具有多样角色的重要酶。它在蛋白质降解、免疫反应和组织重塑中的参与突显了其在生物过程中的重要性。随着研究不断揭示cathepsin的复杂性，它对推进我们对细胞功能的理解和开发创新治疗方法具有巨大潜力。