corepressor

简明释义

英[ˌkəʊrɪˈpresə(r)]美[ˌkoʊrɪˈpresər]

n. [生化] 辅阻遏物，辅抑制物

英英释义

单词用法

同义词

反义词

例句

1.The discovery that the HR protein is a nuclear receptor corepressor indicated that HR function in hair cycling is by regulating gene expression.

HR蛋白是细胞核受体辅阻遏物的发现证明HR蛋白是通过在毛发周期中调节基因表达来发挥作用的。

2.The discovery that the HR protein is a nuclear receptor corepressor indicated that HR function in hair cycling is by regulating gene expression.

HR蛋白是细胞核受体辅阻遏物的发现证明HR蛋白是通过在毛发周期中调节基因表达来发挥作用的。

3.The gene expression was inhibited by a specific corepressor, which binds to the operator region.

特定的核心抑制因子通过结合到操控区抑制了基因表达。

4.In the presence of the corepressor, the transcription of the operon was significantly reduced.

在核心抑制因子的存在下，操纵子的转录显著减少。

5.The study focused on how the corepressor interacts with the repressor protein.

该研究集中于核心抑制因子如何与抑制蛋白相互作用。

6.Adding the corepressor to the culture medium decreased the production of the target protein.

将核心抑制因子添加到培养基中减少了目标蛋白的生产。

7.The role of the corepressor in gene regulation is crucial for understanding metabolic pathways.

在基因调控中，核心抑制因子的作用对理解代谢途径至关重要。

作文

In the vast landscape of molecular biology, understanding the regulation of gene expression is crucial for comprehending how organisms function and adapt. One of the key players in this regulatory mechanism is the molecule known as a corepressor. A corepressor is a type of protein that can bind to a transcription factor and inhibit the transcription of a gene. This process is vital for ensuring that genes are expressed at the right time and in the right amounts, maintaining cellular homeostasis and responding to environmental changes. The role of a corepressor can be illustrated through the example of the lac operon in bacteria. In this system, the presence of glucose leads to the production of a corepressor, which binds to the repressor protein. When the corepressor is bound to the repressor, it changes the shape of the repressor, allowing it to attach to the operator region of the DNA. This binding effectively blocks RNA polymerase from transcribing the downstream genes necessary for lactose metabolism. Therefore, the corepressor plays a pivotal role in regulating the operon, ensuring that energy is conserved by preventing unnecessary gene expression when glucose is available. Moreover, corepressors are not limited to prokaryotic systems. In eukaryotes, they can also play significant roles in gene regulation. For instance, in the context of hormone signaling, certain hormones can activate transcription factors that recruit corepressors to specific gene promoters. This recruitment leads to chromatin remodeling, making the DNA less accessible for transcription machinery. Consequently, the presence of corepressors in eukaryotic cells underscores their importance in fine-tuning gene expression in response to various signals, including hormonal changes, developmental cues, and environmental stresses. The study of corepressors has implications beyond basic biological understanding; it also has potential applications in medicine and biotechnology. For example, understanding how corepressors function can lead to the development of new therapeutic strategies for diseases caused by misregulation of gene expression, such as cancer. By targeting specific corepressors or their pathways, scientists may be able to restore normal gene expression patterns in affected cells, providing a novel approach to treatment. In conclusion, the concept of a corepressor is fundamental to our understanding of gene regulation. These molecules serve as critical regulators that ensure genes are expressed appropriately, adapting to the needs of the cell and the organism as a whole. As research continues to unfold, the significance of corepressors in both prokaryotic and eukaryotic systems highlights their essential role in the intricate network of gene expression regulation. Future studies will likely reveal even more about how corepressors interact with other molecular players, further enhancing our knowledge of cellular processes and opening new avenues for clinical applications.

在分子生物学的广阔领域中，理解基因表达的调控对于理解生物体如何运作和适应至关重要。调控机制中的关键角色之一是被称为corepressor的分子。corepressor是一种能够与转录因子结合并抑制基因转录的蛋白质。这一过程对确保基因在正确的时间和适当的量中表达至关重要，从而维持细胞的稳态，并对环境变化做出反应。 corepressor的作用可以通过细菌中的乳糖操纵子（lac operon）来说明。在这个系统中，葡萄糖的存在导致产生一种corepressor，它与抑制蛋白结合。当corepressor与抑制蛋白结合时，改变了抑制蛋白的形状，使其能够附着在DNA的操纵子区域。这一结合有效地阻止RNA聚合酶转录下游的乳糖代谢所需的基因。因此，corepressor在调节操纵子中起着关键作用，确保在可用葡萄糖时通过防止不必要的基因表达来节省能量。 此外，corepressor并不限于原核系统。在真核生物中，它们也可以在基因调控中发挥重要作用。例如，在激素信号传导的背景下，某些激素可以激活转录因子，这些转录因子招募特定基因启动子上的corepressor。这种招募导致染色质重塑，使DNA对转录机械的可及性降低。因此，真核细胞中corepressor的存在突显了它们在响应各种信号（包括激素变化、发育线索和环境压力）时微调基因表达的重要性。 对corepressor的研究不仅限于基础生物学的理解；它在医学和生物技术方面也具有潜在应用。例如，理解corepressor的功能可以导致开发新的治疗策略，以应对由基因表达失调引起的疾病，例如癌症。通过靶向特定的corepressor或其通路，科学家可能能够恢复受影响细胞中的正常基因表达模式，为治疗提供一种新颖的方法。 总之，corepressor的概念是我们理解基因调控的基础。这些分子作为关键调节因子，确保基因适当地表达，适应细胞和整个生物体的需求。随着研究的不断深入，corepressor在原核和真核系统中的重要性突显了它们在基因表达调控复杂网络中的基本作用。未来的研究可能会进一步揭示corepressor与其他分子参与者之间的相互作用，进一步增强我们对细胞过程的知识，并开辟临床应用的新途径。