cyclase

简明释义

英[/ˈsaɪ.kleɪs/]美[/ˈsaɪ.kleɪs/]

n. 环化酶

英英释义

单词用法

同义词

反义词

例句

1.This leads to stimulation of adenyl cyclase which also is located on the cell surface.

这会刺激位于细胞表面上的腺苷酸环化酶。

2.Dopamine receptors are classified into D1 and D2 types based upon their effects on adenylate cyclase activity and their specific ligands.

多巴胺受体根据其对腺苷酸环化酶活力的不同影响及具有专一性配体分为D 1样和D2样两型。

3.Objective to study the effects of methylene blue (MB), a soluble guanylate cyclase inhibitor, on intestinal perfusion and oxygenation in dogs with septic shock.

目的研究鸟苷酸环化酶抑制药亚甲蓝对感染性休克犬肠道灌注和氧合的影响。

4.Allene oxide cyclase (AOC) catalyzes the stereospecific cyclization of an unstable allene oxide to (9S, 13S)-12-oxo-(10,15Z)-phytodienoic acid, which is the precursor next to jasmonic acid.

丙二烯环化氧化酶AOC能把一种不稳定的具有立体特异性的丙二烯环化物催化氧化成（9S，13S）-12-O-（10，15Z）-植物二烯酸，此植物二烯酸是茉莉酸的最终前体。

5.The mechanism is probably that the consumption of cell mercapto lowers the activity of guanylate cyclase, thus weakening the slackness of blood vessel's smooth muscles.

其机制可能是，细胞巯基耗竭，使鸟苷酸环化酶活性降低，致血管平滑肌松弛作用减弱。

6.Allene oxide cyclase (AOC) catalyzes the stereospecific cyclization of an unstable allene oxide to (9S, 13S)-12-oxo-(10,15Z)-phytodienoic acid, which is the precursor next to jasmonic acid.

丙二烯环化氧化酶AOC能把一种不稳定的具有立体特异性的丙二烯环化物催化氧化成（9S，13S）-12-O-（10，15Z）-植物二烯酸，此植物二烯酸是茉莉酸的最终前体。

7.The enzyme adenylate cyclase plays a crucial role in the signaling pathways of cells.

酶腺苷酸环化酶在细胞的信号传导途径中起着关键作用。

8.Inhibition of cyclase can lead to decreased levels of cyclic AMP.

抑制环化酶可以导致环磷酸腺苷水平降低。

9.Research shows that certain drugs can target cyclase to enhance therapeutic effects.

研究表明，某些药物可以靶向环化酶以增强治疗效果。

10.The activation of guanylate cyclase is important for vascular relaxation.

鸟苷酸环化酶的激活对血管舒张至关重要。

11.Cyclic GMP produced by guanylate cyclase has various physiological functions.

由鸟苷酸环化酶产生的环鸟苷酸具有多种生理功能。

作文

The term cyclase refers to a class of enzymes that play a crucial role in cellular signaling pathways. These enzymes are responsible for catalyzing the conversion of certain molecules, often nucleotides, into cyclic forms. For instance, adenylyl cyclase converts ATP (adenosine triphosphate) into cyclic AMP (cAMP), a significant secondary messenger involved in various physiological processes. The importance of cyclase can be observed in how it influences numerous biological functions, including metabolism, gene expression, and cell proliferation. Understanding the function of cyclase is essential for comprehending how cells communicate with each other. In many cases, the activation of cyclase leads to the production of cAMP, which then activates protein kinases that trigger a cascade of reactions within the cell. This signaling pathway is crucial in mediating responses to hormones and neurotransmitters. For example, when adrenaline binds to its receptor on a cell's surface, it activates adenylyl cyclase, leading to an increase in cAMP levels. This process ultimately results in increased heart rate and energy mobilization, illustrating how cyclase is integral to the body’s response to stress. Moreover, the dysregulation of cyclase activity has been linked to various diseases. For instance, abnormal levels of cAMP can contribute to conditions such as heart disease, diabetes, and cancer. Researchers continue to study cyclase to develop potential therapeutic strategies that target these enzymes. By understanding the mechanisms through which cyclase operates, scientists hope to create drugs that can modulate its activity and restore normal cellular function. In addition to adenylyl cyclase, there are other types of cyclase enzymes, such as guanylyl cyclase, which converts GTP (guanosine triphosphate) into cyclic GMP (cGMP). cGMP serves as another secondary messenger, playing roles in vasodilation and neurotransmission. The interplay between different types of cyclase and their respective cyclic nucleotides adds complexity to cellular signaling networks, enabling cells to respond dynamically to their environment. In conclusion, the enzyme cyclase is fundamental to many biological processes due to its role in generating cyclic nucleotides that act as secondary messengers. Understanding the mechanisms and effects of cyclase is vital for advancing our knowledge of cellular communication and developing new treatments for diseases associated with its dysfunction. As research progresses, the potential for targeting cyclase in medical therapies will likely expand, offering hope for improved health outcomes in the future.

“cyclase”一词指的是一类在细胞信号传导途径中发挥关键作用的酶。这些酶负责催化某些分子（通常是核苷酸）转化为环状形式。例如，腺苷酸cyclase将ATP（腺苷三磷酸）转化为环状AMP（cAMP），这是一种重要的二级信使，参与各种生理过程。cyclase的重要性可以通过其如何影响许多生物功能来观察，包括新陈代谢、基因表达和细胞增殖。 理解cyclase的功能对于理解细胞如何相互通信至关重要。在许多情况下，cyclase的激活会导致cAMP的产生，进而激活蛋白激酶，触发细胞内的一系列反应。这一信号传导通路在介导对激素和神经递质的反应中至关重要。例如，当肾上腺素与细胞表面的受体结合时，它会激活腺苷酸cyclase，导致cAMP水平增加。这个过程最终导致心率增加和能量动员，说明了cyclase在身体应对压力中的重要性。 此外，cyclase活性的失调与各种疾病有关。例如，cAMP的异常水平可能导致心脏病、糖尿病和癌症等疾病。研究人员继续研究cyclase以开发针对这些酶的潜在治疗策略。通过理解cyclase的运作机制，科学家希望创造能够调节其活性并恢复正常细胞功能的药物。 除了腺苷酸cyclase，还有其他类型的cyclase酶，例如鸟苷酸cyclase，它将GTP（鸟苷三磷酸）转化为环状GMP（cGMP）。cGMP作为另一种二级信使，在血管舒张和神经传递中发挥作用。不同类型的cyclase及其各自的环状核苷酸之间的相互作用为细胞信号网络增加了复杂性，使细胞能够动态响应其环境。 总之，酶cyclase由于其在生成作为二级信使的环状核苷酸中的作用而在许多生物过程中是基础的。理解cyclase的机制和效果对推进我们对细胞通信的知识以及开发与其功能障碍相关的疾病的新治疗方法至关重要。随着研究的进展，针对cyclase的医疗治疗潜力可能会扩大，为未来改善健康结果提供希望。