cyclin

简明释义

英[ˈsaɪklɪn]美[ˈsaɪklɪn]

n. 细胞周期素；细胞周期蛋白

英英释义

单词用法

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例句

1.Both clones included a DNA sequence that allow a fluorescent protein expressed in the cell to bind to cyclin D1 RNA the moment it is transcribed.

这两个克隆都包含有一段DNA序列，能在在细胞周期蛋白d1的RNA被转录的时候将荧光蛋白绑定到其上。

2.Cyclin B1, Rabbit anti-Hamster, Mouse, Hamster, Human.

周期素b 1，兔抗仓鼠，小鼠，仓鼠，人。

3.AIM: To evaluate the relationship between RUNX3, cyclin e, P21, biological features and survival in gastric cancer patients.

目的：探讨胃癌RUNX3蛋白表达对细胞周期蛋白的影响及其与胃癌患者生存和生物学特性的关系。

4.They found that the asymmetric activation of one EGFR kinase domain by another is analogous to the activation of cyclin-dependent kinase (CDK) by cyclin, which are involved in regulating cell growth.

他们发现，由一个分子对另外一个EGFR激酶结构域的不对称激活类似于涉及调控细胞生长的细胞周期蛋白激活细胞周期蛋白依赖型激酶的方式。

5.Conclusion Ribozyme targeting cyclin Dl may effectively inhibit cyclin D1 expression and activation in the HSC T6 cell line.

结论载体表达的特异性核酶能有效地抑制HSC的细胞周期蛋白d1的表达和激活。

6.Results Rabbit smooth muscle cells could express cyclin d, the reactant of immune reaction was mainly located in nuclei.

结果发现，主动脉平滑肌细胞可表达细胞周期素d，其免疫反应产物主要位于细胞核内。

7.The role of cyclin in the cell cycle is crucial for regulating cell division.

细胞周期素在细胞周期中的作用对调节细胞分裂至关重要。

8.Research has shown that different types of cyclin are involved in various phases of mitosis.

研究表明，不同类型的细胞周期素参与有丝分裂的不同阶段。

9.The concentration of cyclin fluctuates throughout the cell cycle.

细胞周期素的浓度在整个细胞周期中波动。

10.Mutations in cyclin genes can lead to uncontrolled cell growth.

细胞周期素基因的突变可能导致细胞生长失控。

11.Scientists are studying the interaction between cyclin and cyclin-dependent kinases (CDKs).

科学家们正在研究细胞周期素与细胞周期依赖性激酶（CDK）之间的相互作用。

作文

In the realm of biology, the study of cell division and regulation is crucial for understanding growth, development, and various diseases. One of the key players in this process is a group of proteins known as cyclins. These proteins are essential for the progression of cells through the cell cycle, which consists of several phases: G1, S, G2, and M. The term cyclin refers to their cyclical nature; they are synthesized and degraded in a precise manner during the cell cycle, ensuring that the cell's progression is carefully controlled. The discovery of cyclins revolutionized our understanding of how cells regulate their division. Each cyclin pairs with specific cyclin-dependent kinases (CDKs) to form active complexes that drive the cell cycle forward. For instance, the binding of a particular cyclin to its corresponding CDK triggers the phosphorylation of target proteins, leading the cell into the next phase of the cycle. This mechanism highlights the intricate dance of proteins that orchestrate cellular processes. Moreover, the levels of cyclins fluctuate throughout the cell cycle. During the G1 phase, certain cyclins accumulate in preparation for DNA synthesis, while others are produced in the S phase to facilitate the actual replication of DNA. As the cell transitions into the M phase, different cyclins are activated to promote mitosis, ensuring that the cell divides correctly. After mitosis, the levels of cyclins drop sharply, allowing the cell to exit the cycle and enter a resting state. Understanding cyclins has significant implications for cancer research. Abnormal regulation of cyclins can lead to uncontrolled cell division, a hallmark of cancer. For example, overexpression of certain cyclins has been linked to various cancers, making them potential targets for therapeutic interventions. Researchers are exploring ways to inhibit these proteins or their interactions with CDKs, aiming to develop new treatments that can halt the progression of cancerous cells. In addition to cancer, cyclins play a role in other diseases characterized by abnormal cell proliferation. For instance, some autoimmune diseases are associated with dysregulated cyclin levels, leading to excessive cell growth and inflammation. By studying cyclins, scientists hope to uncover novel approaches to treat these conditions as well. In conclusion, cyclins are vital components of the cell cycle, driving the progression of cell division through their regulated synthesis and degradation. Their importance extends beyond basic biology, as they hold the key to understanding and potentially treating various diseases, particularly cancer. As research continues to unveil the complexities of cyclins and their interactions within the cell cycle, we move closer to developing innovative therapies that can target these proteins effectively. The journey of understanding cyclins is not just an academic pursuit; it is a path toward improving human health and combating diseases that arise from cellular misregulation.

在生物学领域，细胞分裂和调控的研究对于理解生长、发育和各种疾病至关重要。其中一个关键角色是一组被称为cyclins的蛋白质。这些蛋白质对于细胞通过细胞周期的进展是必不可少的，细胞周期由几个阶段组成：G1、S、G2和M。术语cyclin指的是它们的周期性特征；它们在细胞周期中以精确的方式合成和降解，从而确保细胞的进展受到严格控制。 cyclins的发现彻底改变了我们对细胞如何调节其分裂的理解。每个cyclin与特定的细胞周期依赖性激酶（CDK）配对，形成活性复合物，推动细胞周期的向前发展。例如，特定cyclin与其相应CDK的结合触发目标蛋白的磷酸化，使细胞进入下一个周期阶段。这一机制突显了协调细胞过程的蛋白质之间复杂的相互作用。 此外，cyclins的水平在整个细胞周期中波动。在G1阶段，某些cyclins在DNA合成前积累，而在S阶段则产生其他cyclins以促进实际的DNA复制。随着细胞过渡到M阶段，不同的cyclins被激活以促进有丝分裂，确保细胞正确分裂。在有丝分裂后，cyclins的水平急剧下降，使细胞能够退出周期并进入休息状态。 理解cyclins对癌症研究具有重要意义。cyclins的异常调节可能导致不受控制的细胞分裂，这是癌症的一个标志。例如，某些cyclins的过表达与各种癌症相关，使其成为潜在的治疗干预目标。研究人员正在探索抑制这些蛋白质或它们与CDK相互作用的方法，旨在开发能够阻止癌细胞进展的新疗法。 除了癌症，cyclins在其他以异常细胞增殖为特征的疾病中也发挥作用。例如，一些自身免疫性疾病与cyclins水平失调有关，导致细胞生长过度和炎症。通过研究cyclins，科学家希望发现治疗这些疾病的新方法。 总之，cyclins是细胞周期的重要组成部分，通过其调控的合成和降解推动细胞分裂的进展。它们的重要性超越了基础生物学，因为它们是理解和潜在治疗各种疾病的关键，特别是癌症。随着研究不断揭示cyclins及其在细胞周期中相互作用的复杂性，我们离开发展有效靶向这些蛋白质的创新疗法又近了一步。理解cyclins的旅程不仅仅是学术追求；它是改善人类健康和对抗因细胞失调而产生的疾病的路径。