cyclize

简明释义

英[ˈsaɪklaɪz]美[ˈsɪklaɪz]

vt. 使环化

第 三 人 称 单 数 c y c l i z e s

现 在 分 词 c y c l i z i n g

过 去 式 c y c l i z e d

过 去 分 词 c y c l i z e d

英英释义

单词用法

同义词

反义词

例句

1.In existence of the anhydrous sodium acetate using 5 chloroacetylbarbituric acid to cyclize and condense with different aromatic aldehydes to synthesize a series of aurones.

用氯乙酰巴比妥酸在无水乙酸钠存在下环合后再与不同的芳香醛缩合合成噢类化合物。

2.In existence of the anhydrous sodium acetate using 5 chloroacetylbarbituric acid to cyclize and condense with different aromatic aldehydes to synthesize a series of aurones.

用氯乙酰巴比妥酸在无水乙酸钠存在下环合后再与不同的芳香醛缩合合成噢类化合物。

3.The objective is to cyclize and condense with different aromatic aldehydes to synthesize a series of aurones.

目的是与不同的芳香醛进行环合和缩合，以合成一系列的金酮。

4.In organic chemistry, researchers often aim to cyclize compounds to enhance their stability.

在有机化学中，研究人员通常旨在环化化合物以增强其稳定性。

5.The process of cyclizing linear molecules can lead to the formation of more complex structures.

将线性分子环化的过程可以导致更复杂结构的形成。

6.Scientists discovered a new method to cyclize polyenes effectively.

科学家发现了一种有效的环化多烯的方法。

7.To synthesize the desired product, we need to cyclize the precursor compound.

为了合成所需的产品，我们需要对前体化合物进行环化。

8.The reaction conditions must be optimized to successfully cyclize the substrate.

反应条件必须优化，以成功地对底物进行环化。

作文

In the field of chemistry, the term cyclize refers to a process in which a linear molecule forms a ring structure through the formation of covalent bonds. This transformation is crucial in the synthesis of many organic compounds, particularly in the creation of cyclic compounds that exhibit unique properties compared to their acyclic counterparts. The ability to cyclize a molecule can significantly alter its chemical behavior, stability, and reactivity, making it a vital concept for chemists and researchers alike. For example, consider the synthesis of penicillin, a well-known antibiotic. The initial linear precursor undergoes a series of chemical reactions, one of which involves the cyclization of specific components to form the characteristic beta-lactam ring. This ring structure is essential for the antibiotic's function, as it allows the compound to effectively inhibit bacterial cell wall synthesis. Without the ability to cyclize, the resulting compound would lack the necessary biological activity to combat infections. Moreover, the process of cyclizing molecules is not limited to natural products. In the realm of synthetic organic chemistry, chemists often seek to create new cyclic compounds with desired properties. For instance, pharmaceutical companies invest significant resources into developing drugs that contain cyclic structures, as these compounds often exhibit improved potency and selectivity. The ability to cyclize a molecule can lead to the discovery of novel therapeutic agents that may be more effective in treating various diseases. The mechanism by which a molecule cyclizes can vary greatly depending on the functional groups present and the reaction conditions. Some common methods of cyclization include intramolecular nucleophilic attacks, where a nucleophile within the same molecule attacks an electrophile, leading to ring formation. Other methods involve the use of catalysts or reagents that facilitate the cyclization process, allowing for the formation of complex cyclic structures from simpler precursors. In addition to its significance in organic synthesis, the concept of cyclization extends to other fields such as materials science and biochemistry. For instance, in polymer chemistry, the cyclization of monomers can lead to the formation of cyclic polymers, which possess unique mechanical and thermal properties. These materials find applications in various industries, including aerospace, automotive, and electronics. Biochemically, the cyclization of peptides and proteins is also a critical process. Many biologically active peptides are cyclic in nature, which enhances their stability and bioavailability. The ability to cyclize peptide chains can result in molecules that are more resistant to enzymatic degradation, making them suitable candidates for therapeutic development. In conclusion, the term cyclize encompasses a fundamental process in chemistry that involves the transformation of linear molecules into cyclic structures. This process is pivotal in both natural and synthetic chemistry, leading to the development of important compounds with diverse applications. Understanding how to induce cyclization can unlock new pathways for drug discovery, materials innovation, and biochemical research, highlighting the importance of this concept in the scientific community.

在化学领域，术语cyclize指的是一个线性分子通过共价键的形成而形成环状结构的过程。这一转变在许多有机化合物的合成中至关重要，特别是在创建具有独特性质的环状化合物时。能够cyclize一个分子可以显著改变其化学行为、稳定性和反应性，使其成为化学家和研究人员的重要概念。 例如，考虑青霉素的合成，这是一种众所周知的抗生素。最初的线性前体经历了一系列化学反应，其中之一涉及特定组分的cyclization，形成特征性的β-内酰胺环。这个环状结构对抗生素的功能至关重要，因为它使化合物能够有效抑制细菌细胞壁的合成。如果没有能够cyclize的能力，所得到的化合物将缺乏对抗感染所需的生物活性。 此外，cyclizing分子的过程并不仅限于天然产品。在合成有机化学的领域，化学家们常常寻求创造具有所需特性的新的环状化合物。例如，制药公司在开发含有环状结构的药物方面投入了大量资源，因为这些化合物通常表现出更好的效力和选择性。能够cyclize一个分子可以导致新型治疗剂的发现，这些治疗剂在治疗各种疾病方面可能更为有效。 一个分子如何cyclizes的机制可能因存在的功能团和反应条件而大相径庭。一些常见的cyclization方法包括分子内亲核攻击，其中同一分子内的亲核试剂攻击电亲核试剂，从而导致环的形成。其他方法涉及使用催化剂或试剂来促进cyclization过程，从而允许从简单前体形成复杂的环状结构。 除了在有机合成中的重要性，cyclization的概念还扩展到材料科学和生物化学等其他领域。例如，在聚合物化学中，单体的cyclization可以导致环状聚合物的形成，这些聚合物具有独特的机械和热性能。这些材料在航空航天、汽车和电子等各个行业都有应用。 在生物化学中，肽和蛋白质的cyclization也是一个关键过程。许多生物活性肽是环状的，这增强了它们的稳定性和生物利用度。能够cyclize肽链可以导致更耐酶降解的分子，使其成为治疗开发的合适候选者。 总之，术语cyclize涵盖了化学中一个基本的过程，即线性分子转变为环状结构。这一过程在自然和合成化学中都是至关重要的，导致重要化合物的发展，具有多样的应用。理解如何诱导cyclization可以开启药物发现、材料创新和生物化学研究的新途径，突显了这一概念在科学界的重要性。