degranulation

简明释义

英[diːˌɡrænjʊˈleɪʃən]美[dɪˌɡrænuˈleɪʃən]

n. （细胞的）脱粒；失粒

英英释义

单词用法

同义词

反义词

例句

1.The rate of mast cell degranulation was studied on ligature marks of human skin.

本文观察人体皮肤索沟局部肥大细胞脱颗粒率变化。

2.In addition to T-lymphocyte participation, mast cells in the choroid play an accessory role with data that degranulation of choroidal mast cells occurred prior to the onset of the disease.

根据在疾病发作以前，脉络膜的肥大细胞发生脱颗粒作用，说明除了淋巴细胞参与以外，脉络膜的肥大细胞也起了附带作用。

3.The modified Human Basophil Degranulation Test (HCDT) is a simple way to assess the degranulation of human basophils to the specific allergens.

改良的人嗜碱细胞脱颗粒试验是一种观察人嗜碱细胞对特异性变应原脱颗粒反应的简易方法。

4.Linear correlation analysis showed that the gastric perception threshold decreased in concordance with the increase of degranulation of 5-ht-positive cells.

直线相关分析显示，5 - HT阳性细胞释放介质越多，胃感知阈值越低。

5.In asthma mast cell degranulation was observed electron microscopically in different degree, but in CB it was not observed.

电镜下可见哮喘组有肥大细胞不同程度的脱颗粒现象，而慢支组未见到。

6.Methods: Human basophil degranulation test (HBDT), ELISA were evaluated and compared in 30 healthy subjects and 30 asthmatics, using respectively WBE and FE.

方法：支气管哮喘患者和健康人各30例，分别以WBE和FE作人嗜碱粒细胞脱颗粒试验(HBDT)、ELISA进行比较。

7.It can be elucidated from the result of this study that benadryl and cimetidine have the effect to inhibit the degranulation of mast cells.

本实验似可以说明：苯海拉明、甲氰脒胍有抑制肥大细胞脱颗粒作用。

8.The immune response involves the process of degranulation, which is the release of granules from mast cells.

免疫反应涉及到脱颗粒的过程，即从肥大细胞释放颗粒。

9.During an allergic reaction, degranulation of mast cells can lead to inflammation.

在过敏反应中，肥大细胞的脱颗粒可能导致炎症。

10.The study focused on how degranulation affects the body's defense mechanisms.

这项研究集中于脱颗粒如何影响身体的防御机制。

11.Histamine is released during degranulation, causing symptoms such as itching and swelling.

在脱颗粒过程中，组胺被释放，导致瘙痒和肿胀等症状。

12.The researchers observed that degranulation was triggered by certain pathogens.

研究人员观察到某些病原体引发了脱颗粒。

作文

Degranulation is a crucial biological process that occurs in various types of cells, particularly in immune cells such as mast cells and basophils. This process involves the release of granules containing various bioactive substances, including histamines, cytokines, and enzymes, which play significant roles in inflammation and immune responses. Understanding degranulation (去颗粒化) is essential for comprehending how our body responds to allergens, pathogens, and other harmful stimuli. In the context of allergic reactions, degranulation (去颗粒化) is often triggered by the binding of allergens to IgE antibodies on the surface of mast cells. When this occurs, it leads to the rapid release of granules filled with histamine and other mediators. Histamine, for instance, is responsible for many of the symptoms associated with allergies, such as itching, swelling, and redness. This immediate hypersensitivity reaction can significantly affect an individual's quality of life and may require medical intervention. Moreover, degranulation (去颗粒化) is not only limited to allergic responses but also plays a vital role in the body's defense against infections. When immune cells encounter pathogens, they can undergo degranulation (去颗粒化) to release substances that help to neutralize or eliminate these invaders. For example, neutrophils and eosinophils, another type of immune cell, release granules that contain enzymes capable of digesting bacterial cell walls or attacking parasites. This process is essential for maintaining the body's health and preventing infections from taking hold. In addition to its role in immunity, the process of degranulation (去颗粒化) can also contribute to tissue remodeling and repair. After an injury, immune cells migrate to the site of damage and undergo degranulation (去颗粒化) to release growth factors and other molecules that promote healing. This aspect of degranulation (去颗粒化) highlights its importance not only in fighting off pathogens but also in facilitating recovery from injuries. However, dysregulation of degranulation (去颗粒化) can lead to various pathological conditions. For instance, excessive or inappropriate degranulation (去颗粒化) can result in chronic inflammation, contributing to diseases such as asthma, rheumatoid arthritis, and other autoimmune disorders. Understanding the mechanisms that regulate degranulation (去颗粒化) is therefore critical for developing targeted therapies to manage these conditions effectively. Research into degranulation (去颗粒化) continues to evolve, with scientists exploring the signaling pathways and molecular interactions that govern this process. Advances in understanding these mechanisms may lead to new treatments that can modulate degranulation (去颗粒化) in a way that alleviates symptoms of allergic reactions or reduces chronic inflammation. In conclusion, degranulation (去颗粒化) is a fundamental process in the immune system that plays a vital role in both defense and repair. Its implications extend beyond simple immune responses to include significant impacts on health and disease. By continuing to study degranulation (去颗粒化), we can better understand its complexities and develop innovative strategies to enhance health outcomes.

去颗粒化是一个重要的生物过程，发生在各种类型的细胞中，尤其是在免疫细胞如肥大细胞和嗜碱细胞中。这个过程涉及释放含有多种生物活性物质的颗粒，包括组胺、细胞因子和酶，这些物质在炎症和免疫反应中发挥着重要作用。理解去颗粒化（degranulation）对于理解我们身体如何应对过敏原、病原体和其他有害刺激至关重要。 在过敏反应的背景下，去颗粒化（degranulation）通常是由过敏原与肥大细胞表面的IgE抗体结合触发的。当这种情况发生时，会导致快速释放充满组胺和其他介质的颗粒。例如，组胺负责与过敏相关的许多症状，如瘙痒、肿胀和红肿。这种即时超敏反应会显著影响个体的生活质量，可能需要医疗干预。 此外，去颗粒化（degranulation）不仅限于过敏反应，还在身体抵御感染中发挥着重要作用。当免疫细胞遇到病原体时，它们可以经历去颗粒化（degranulation），释放有助于中和或消灭这些入侵者的物质。例如，中性粒细胞和嗜酸细胞是另一种类型的免疫细胞，它们释放含有能够消化细菌细胞壁或攻击寄生虫的酶的颗粒。这个过程对于维持身体健康和防止感染的发生至关重要。 除了在免疫中的作用，去颗粒化（degranulation）过程还可以促进组织重塑和修复。在受伤后，免疫细胞迁移到损伤部位并经历去颗粒化（degranulation），释放生长因子和其他促进愈合的分子。去颗粒化（degranulation）的这一方面突显了它在抵御病原体和促进伤后恢复中的重要性。 然而，去颗粒化（degranulation）的失调可能导致各种病理状态。例如，过度或不当的去颗粒化（degranulation）可能导致慢性炎症，进而促成哮喘、类风湿性关节炎和其他自身免疫疾病等病症。因此，理解调节去颗粒化（degranulation）机制对于开发针对这些疾病的靶向疗法至关重要。 关于去颗粒化（degranulation）的研究不断发展，科学家们正在探索调控这一过程的信号通路和分子相互作用。了解这些机制的进展可能会导致新治疗方法的出现，从而以减轻过敏反应的症状或减少慢性炎症。 总之，去颗粒化（degranulation）是免疫系统中的一个基本过程，在防御和修复中发挥着重要作用。其影响不仅限于简单的免疫反应，还对健康和疾病产生重大影响。通过继续研究去颗粒化（degranulation），我们可以更好地理解其复杂性，并开发创新策略以改善健康结果。