derivatization

简明释义

英[dɪˌrɪvətaɪˈzeɪʃən]美[dəˈrɪvəˌtɪzeɪʃən]

n. 衍生；衍生化；衍生化作用

英英释义

单词用法

同义词

反义词

例句

1.Finally, the chemical compositions of the fine product after derivatization were examined by the gas chromatography-mass spectrometric analysis.

将精多糖衍生化后运用气相色谱-质谱法对其化学成分进行分析。

2.A microwave-assisted derivatization and GC-MS method coupled with calibration transformation matrix was developed for determination of fatty acid in edible oils.

建立了微波衍生化gc - MS测定食用植物油中的脂肪酸含量，并采用校正变换矩阵法对食用植物油的成分进行测定的方法。

3.Meanwhile, the influence of derivatization condition on it was tested, such as the derivatization reagent, time and temperature.

同时考察了衍生化条件对该试验的影响，考察内容包括衍生化试剂、衍生化时间、衍生化温度等内容。

4.In recent years, many researchers have used chemical derivatization in HPLC in attempt to improve detection sensitivity and separation efficiency.

近年来许多研究人员将化学衍生法应用于高效液相色谱中，试图提高检测灵敏度和改善分离效果。

5.The fragmentation pathway of raddeanin A was studied by electrospray ionization mass spectrometry(ESI-MS/MS) together with chemical derivatization.

以化学衍生结合电喷雾电离质谱（ESI-MS/MS）法研究银莲花素A的质谱裂解方式。

6.The in vitro biotransformation of 6 methoxy butyl phthalide (MBP) by phenobarbital induced rat liver microsomes was investigated by GC/MS and GC/MS with TMS derivatization.

报道了用GC／MS方法及衍生化技术研究6甲氧基正丁苯酞（MBP）在大鼠肝微粒体中的代谢转化结果。

7.The total workflow of optimum rapid hydrolysis, robotic sample derivatization, and a robust analytical solution leads to higher throughput for accurate and precise amino acid analysis.

最宜的迅速水解、机器人样品衍生作用和一种健壮分析解答总工作流导致准确和精确氨基酸分析的更高的生产量。

8.Separation of 1, 1 '-binaphthalene-2, 2' -diol Optical Isomers by Derivatization High Performance Liquid Chromatography.

衍生化高效液相色谱法拆分1,1'-联萘-2,2 ' -二酚光学异构体。

9.In analytical chemistry, derivatization is often necessary to improve the detection of compounds.

在分析化学中，衍生化通常是必要的，以提高化合物的检测能力。

10.The derivatization process can enhance the volatility of certain molecules for gas chromatography.

该衍生化过程可以增强某些分子的挥发性，以便进行气相色谱分析。

11.To analyze amino acids, we performed a derivatization step using phenyl isothiocyanate.

为了分析氨基酸，我们使用苯基异硫氰酸酯进行了一个衍生化步骤。

12.The derivatization of fatty acids can help in their identification through mass spectrometry.

脂肪酸的衍生化可以帮助通过质谱法进行识别。

13.We used derivatization to convert alcohols into more detectable derivatives.

我们使用衍生化将醇转化为更易检测的衍生物。

作文

In the field of analytical chemistry, one of the most crucial techniques employed for enhancing the detection and analysis of various compounds is known as derivatization. This process involves the chemical modification of a compound to improve its properties, such as volatility, stability, or detectability. By transforming a substance into a derivative, chemists can facilitate its analysis using various methods, including gas chromatography (GC) and liquid chromatography (LC). The importance of derivatization cannot be overstated, as it plays a pivotal role in the identification and quantification of compounds that are otherwise difficult to analyze due to their inherent characteristics. The concept of derivatization can be illustrated through its application in the analysis of amino acids. Amino acids, which are the building blocks of proteins, often exist in forms that are not easily detectable by standard analytical techniques. To overcome this limitation, chemists employ derivatization to convert these amino acids into more volatile and stable derivatives. For instance, the use of phenyl isothiocyanate (PITC) can lead to the formation of phenylthiocarbamoyl (PTC) derivatives. These derivatives possess enhanced properties that allow for improved separation and detection during chromatographic analysis. Moreover, derivatization is not limited to amino acids; it is widely used in the analysis of other organic compounds, including sugars, fatty acids, and pharmaceuticals. Each class of compounds may require specific derivatizing agents and conditions to achieve optimal results. For example, the analysis of fatty acids often involves the conversion of free fatty acids into their corresponding methyl esters using reagents like boron trifluoride (BF3). This transformation not only simplifies the analysis but also enhances the sensitivity of the detection method. The process of derivatization typically involves several steps: selecting an appropriate derivatizing agent, mixing it with the target compound, and then allowing the reaction to proceed under controlled conditions. Following the reaction, the resulting derivatives can be analyzed using various chromatographic techniques. The choice of method depends on the nature of the compound and the desired outcome of the analysis. Despite its advantages, derivatization does come with certain challenges. The reaction conditions must be carefully optimized to ensure complete conversion of the target compound while minimizing side reactions that could produce undesired by-products. Additionally, the stability of the formed derivatives must be considered, as some may degrade over time or under specific conditions, potentially leading to inaccurate results. In conclusion, derivatization is an essential technique in analytical chemistry that significantly enhances the ability to analyze a wide range of compounds. Its applications span various fields, from pharmaceuticals to environmental science, making it a versatile tool for chemists. By improving the detectability and stability of compounds, derivatization allows for more accurate and efficient analyses, ultimately contributing to advancements in scientific research and industry practices. As analytical methods continue to evolve, the role of derivatization will undoubtedly remain vital in the quest for precise and reliable chemical analysis.

在分析化学领域，一种用于增强各种化合物检测和分析的关键技术被称为衍生化。这个过程涉及对化合物进行化学改性，以改善其属性，例如挥发性、稳定性或可检测性。通过将物质转化为衍生物，化学家可以利用包括气相色谱（GC）和液相色谱（LC）在内的各种方法来促进其分析。衍生化的重要性不容小觑，因为它在识别和定量那些由于其固有特性而难以分析的化合物中发挥着关键作用。 衍生化的概念可以通过其在氨基酸分析中的应用来说明。氨基酸是蛋白质的基本组成部分，通常以不易被标准分析技术检测的形式存在。为了克服这一限制，化学家们采用衍生化将这些氨基酸转变为更具挥发性和稳定性的衍生物。例如，使用苯异硫氰酸酯（PITC）可以形成苯硫脲（PTC）衍生物。这些衍生物具有增强的特性，允许在色谱分析过程中实现更好的分离和检测。 此外，衍生化并不仅限于氨基酸；它广泛应用于其他有机化合物的分析，包括糖类、脂肪酸和药物。每类化合物可能需要特定的衍生化试剂和条件，以实现最佳结果。例如，脂肪酸的分析通常涉及将游离脂肪酸转化为相应的甲基酯，使用的试剂如氟化硼（BF3）。这种转化不仅简化了分析过程，还提高了检测方法的灵敏度。 衍生化的过程通常包括几个步骤：选择合适的衍生化试剂，将其与目标化合物混合，然后在控制条件下让反应进行。在反应后，生成的衍生物可以利用各种色谱技术进行分析。所选方法取决于化合物的性质和分析的预期结果。 尽管具有优势，衍生化确实面临某些挑战。反应条件必须仔细优化，以确保目标化合物的完全转化，同时最小化可能产生不良副产物的副反应。此外，形成的衍生物的稳定性也必须考虑，因为某些衍生物可能会随时间或在特定条件下降解，从而导致结果不准确。 总之，衍生化是分析化学中一种重要的技术，它显著增强了分析广泛化合物的能力。其应用跨越多个领域，从制药到环境科学，使其成为化学家的一种多功能工具。通过改善化合物的可检测性和稳定性，衍生化使得分析更加准确和高效，最终促进了科学研究和工业实践的进步。随着分析方法的不断发展，衍生化在追求精确可靠的化学分析中的作用无疑将继续保持重要。