desmosomal

简明释义

英[/ˌdɛz.məˈsəʊ.məl/]美[/ˌdɛz.məˈsoʊ.məl/]

桥粒的

英英释义

单词用法

同义词

反义词

例句

1.The cytoplasm between the desmosomal attachments shrinks .

桥粒间的细胞质皱缩。

2.The cytoplasm between the desmosomal attachments shrinks .

桥粒间的细胞质皱缩。

3.The cytoplasm between the desmosomal attachments shrinks.

桥粒间的细胞质皱缩。

4.The study focused on the role of desmosomal 细胞间连接的 proteins in skin integrity.

这项研究集中于< span>细胞间连接的蛋白质在皮肤完整性中的作用。

5.Mutations in desmosomal 细胞间连接的 genes can lead to various skin disorders.

在< span>细胞间连接的基因中发生突变可能导致各种皮肤疾病。

6.Researchers are investigating the impact of desmosomal 细胞间连接的 dysfunction in heart diseases.

研究人员正在调查< span>细胞间连接的功能障碍对心脏疾病的影响。

7.The effectiveness of the treatment was linked to the stability of desmosomal 细胞间连接的 junctions.

治疗的有效性与< span>细胞间连接的连接的稳定性有关。

8.In epithelial tissues, desmosomal 细胞间连接的 adhesion is crucial for maintaining structure.

在上皮组织中，< span>细胞间连接的粘附对于维持结构至关重要。

作文

The human body is a complex system made up of various cells, tissues, and organs that work together to maintain life. One of the critical components of cellular structure is the presence of junctions that bind cells together, ensuring the integrity and functionality of tissues. Among these junctions, the term desmosomal refers to a type of cell adhesion structure that plays an essential role in maintaining the mechanical stability of tissues, particularly in areas subjected to significant stress, such as the skin and heart. Desmosomal junctions are specialized structures that connect the intermediate filaments of adjacent cells, allowing them to withstand tensile forces and prevent separation during physical stress. In the skin, for instance, desmosomal connections are crucial for the formation of a robust epidermal barrier. The keratinocytes, which are the predominant cell type in the outer layer of the skin, rely on desmosomal junctions to adhere firmly to one another. This adhesion not only provides structural support but also plays a vital role in the skin's ability to resist abrasions and injuries. When the desmosomal structures are compromised, it can lead to skin disorders characterized by blistering and fragility, illustrating the importance of these junctions in maintaining skin integrity. Similarly, in cardiac tissue, desmosomal junctions are essential for the proper functioning of the heart. Cardiac myocytes, or heart muscle cells, are interconnected by desmosomal structures known as intercalated discs. These discs facilitate strong adhesion between adjacent myocytes, enabling coordinated contractions necessary for effective pumping of blood. Disruption of desmosomal adhesion in cardiac tissue can lead to serious conditions such as cardiomyopathy, where the heart muscle becomes weakened and unable to pump blood efficiently. Research into desmosomal proteins has revealed their significance not only in normal physiology but also in various diseases. Mutations in genes encoding desmosomal proteins can lead to a range of genetic disorders, including skin blistering diseases and certain types of cardiomyopathies. Understanding the molecular mechanisms underlying desmosomal adhesion is therefore crucial for developing potential therapies for these conditions. Scientists are exploring ways to enhance desmosomal function in diseased tissues, aiming to restore proper cell adhesion and improve tissue resilience. In conclusion, the study of desmosomal structures highlights the intricate relationships between cellular architecture and tissue function. These junctions are vital for maintaining the structural integrity of tissues under mechanical stress, and their disruption can have significant clinical implications. As research continues to uncover the roles of desmosomal proteins in health and disease, we gain a deeper appreciation for the complexity of cellular interactions that sustain life. By focusing on desmosomal mechanisms, we can pave the way for innovative therapeutic approaches that target these critical components of cellular adhesion, ultimately enhancing our understanding of tissue biology and pathology.

人类身体是一个复杂的系统，由各种细胞、组织和器官组成，这些组成部分共同工作以维持生命。其中，细胞结构的重要组成部分是连接细胞的连接点，这些连接确保了组织的完整性和功能。在这些连接中，术语desmosomal指的是一种细胞粘附结构，在维持组织的机械稳定性方面发挥着重要作用，尤其是在皮肤和心脏等承受巨大压力的区域。Desmosomal连接是将相邻细胞的中间纤维连接在一起的专门结构，使它们能够承受拉伸力，并防止在物理压力下分离。 例如，在皮肤中，desmosomal连接对形成坚固的表皮屏障至关重要。角质形成细胞是皮肤外层的主要细胞类型，它们依靠desmosomal连接紧密相连。这种粘附不仅提供了结构支持，还在皮肤抵御擦伤和损伤的能力中发挥着重要作用。当desmosomal结构受到损害时，可能导致以水泡和脆弱为特征的皮肤疾病，从而说明了这些连接在维持皮肤完整性方面的重要性。 同样，在心脏组织中，desmosomal连接对于心脏的正常功能至关重要。心肌细胞或心脏肌肉细胞通过称为间盘的desmosomal结构相互连接。这些间盘促进相邻心肌细胞之间的强粘附，使得有效的血液泵送所需的协调收缩成为可能。在心脏组织中，desmosomal粘附的破坏可能导致严重的疾病，如心肌病，其中心肌变得虚弱，无法有效泵送血液。 对desmosomal蛋白的研究揭示了它们在正常生理和各种疾病中的重要性。编码desmosomal蛋白的基因突变可能导致一系列遗传疾病，包括皮肤水泡病和某些类型的心肌病。因此，理解desmosomal粘附背后的分子机制对于开发这些疾病的潜在疗法至关重要。科学家们正在探索增强患病组织中desmosomal功能的方法，旨在恢复适当的细胞粘附并改善组织的韧性。 总之，对desmosomal结构的研究突显了细胞结构与组织功能之间的复杂关系。这些连接对于在机械压力下维持组织的结构完整性至关重要，其破坏可能具有重大临床意义。随着研究的不断深入，揭示了desmosomal蛋白在健康和疾病中的作用，我们对维持生命的细胞相互作用的复杂性有了更深刻的理解。通过关注desmosomal机制，我们可以为针对这些关键细胞粘附成分的创新治疗方法铺平道路，最终增强我们对组织生物学和病理学的理解。