desmosome

简明释义

英[ˈdesməˌsəʊm]美[ˈdezməsoʊm]

n. 细胞桥粒（上皮细胞膜中的局部增厚部份）

英英释义

单词用法

同义词

反义词

例句

1.At three points along the way there are specialized junctions: (1) zonula occludens or tight junctions, (2) zonula adherens or intermediate junction, and (3) desmosome or macula adherens.

其中，有三个特殊的细胞连接结构。（1）为紧密连接，（2）为黏着小带（3）为桥粒。

2.At three points along the way there are specialized junctions: (1) zonula occludens or tight junctions, (2) zonula adherens or intermediate junction, and (3) desmosome or macula adherens.

其中，有三个特殊的细胞连接结构。（1）为紧密连接，（2）为黏着小带（3）为桥粒。

3.Results At the 10th week after constriction, the structure of cadherin, desmosome and gap junction in intercalated discs were destroyed, gap of intercellular space widened.

结果术后10周手术组心肌闰盘的粘着膜、桥粒、间隙连接结构模糊，连接间隙增宽；

4.In a case of short limb malformation, the perinodal loops were thinner, there were more desmosome strings between the loops.

在短肢畸型病例中，结旁环较薄，环间桥粒串较多。

5.The structure of a cell is supported by various junctions, including the desmosome 细胞间粘附体, which helps maintain tissue integrity.

细胞的结构由多种连接支持，包括desmosome 细胞间粘附体，这有助于维持组织的完整性。

6.In skin cells, the desmosome 细胞间粘附体 plays a crucial role in resisting mechanical stress.

在皮肤细胞中，desmosome 细胞间粘附体 在抵抗机械压力方面起着至关重要的作用。

7.Mutations in genes responsible for desmosome 细胞间粘附体 proteins can lead to skin diseases.

负责desmosome 细胞间粘附体 蛋白质的基因突变可能导致皮肤疾病。

8.Research has shown that desmosome 细胞间粘附体 formation is essential for cardiac muscle function.

研究表明，desmosome 细胞间粘附体 的形成对心脏肌肉功能至关重要。

9.The adhesion provided by the desmosome 细胞间粘附体 is vital in epithelial tissues.

由desmosome 细胞间粘附体 提供的粘附力在上皮组织中至关重要。

作文

In the complex world of cellular biology, understanding the structures that hold our cells together is crucial. One such structure is the desmosome, a specialized junction that provides mechanical strength to tissues. Desmosomes are particularly abundant in tissues that experience significant stress, such as cardiac muscle and epithelial layers. They function like rivets, anchoring adjacent cells together and ensuring that they remain intact during physical strain. This is vital for maintaining the integrity of tissues, especially in organs that undergo constant movement or pressure. The structure of a desmosome is fascinating. It consists of dense protein plaques on the inner surface of the cell membrane, which are linked by cadherin proteins. These cadherins extend into the extracellular space and interact with cadherins from neighboring cells, creating a strong adhesive bond. The cytoplasmic side of the desmosome is connected to intermediate filaments of the cytoskeleton, which further enhances its stability. This unique arrangement allows cells to withstand mechanical forces without breaking apart. In addition to their structural role, desmosomes also play a part in signaling pathways that regulate cell behavior. They can influence cellular responses to stress and injury, making them essential in tissue repair processes. For instance, when skin is damaged, the cells at the wound site rely on desmosomes to maintain cohesion while new cells migrate to heal the area. This highlights the importance of desmosomes not just in maintaining physical integrity, but also in facilitating communication between cells during critical processes like healing. Moreover, disruptions in desmosome function can lead to various diseases. Conditions such as pemphigus vulgaris, an autoimmune disorder, occur when antibodies attack the proteins that form desmosomes, resulting in blistering of the skin. Similarly, certain types of heart disease are associated with mutations in the genes encoding desmosomal proteins, leading to weakened cardiac tissue and increased risk of arrhythmias. This illustrates how integral desmosomes are to both health and disease. Research into desmosomes continues to be a vibrant field, as scientists seek to uncover more about their functions and potential therapeutic targets. Understanding how desmosomes operate could lead to innovative treatments for conditions related to their dysfunction. For example, strategies aimed at enhancing desmosome stability could be beneficial in treating skin disorders or heart diseases linked to these structures. In conclusion, desmosomes are more than just cellular glue; they are dynamic structures that play critical roles in maintaining tissue integrity, facilitating communication during healing, and influencing disease processes. Their study not only deepens our understanding of cellular architecture but also opens avenues for medical advancements. As we continue to explore the intricacies of desmosomes, we gain valuable insights into the fundamental principles of biology that govern life itself.

在细胞生物学的复杂世界中，理解将细胞结合在一起的结构至关重要。其中一个结构就是细胞间连接体，它是一种特殊的连接，提供了组织的机械强度。细胞间连接体在经历显著压力的组织中尤其丰富，例如心脏肌肉和上皮层。它们像铆钉一样，将相邻的细胞固定在一起，确保它们在物理应力下保持完整。这对于维持组织的完整性至关重要，尤其是在不断运动或承受压力的器官中。 细胞间连接体的结构非常迷人。它由细胞膜内侧的致密蛋白质斑块组成，这些斑块通过钙黏蛋白连接。钙黏蛋白延伸到细胞外空间，并与邻近细胞的钙黏蛋白相互作用，形成强大的粘附键。细胞间连接体的细胞质侧与细胞骨架的中间丝相连，进一步增强其稳定性。这种独特的排列使细胞能够承受机械力而不破裂。 除了结构作用外，细胞间连接体还在调节细胞行为的信号通路中发挥作用。它们可以影响细胞对压力和损伤的反应，使其在组织修复过程中至关重要。例如，当皮肤受损时，伤口部位的细胞依赖于细胞间连接体保持凝聚力，同时新细胞迁移以愈合该区域。这突显了细胞间连接体不仅在维持物理完整性方面的重要性，还在关键过程如愈合期间促进细胞之间的沟通。 此外，细胞间连接体功能的破坏可能导致各种疾病。例如，天疱疮等自身免疫性疾病发生在抗体攻击形成细胞间连接体的蛋白质时，导致皮肤起水泡。同样，某些类型的心脏病与编码细胞间连接体蛋白的基因突变有关，导致心脏组织减弱和心律失常风险增加。这说明了细胞间连接体在健康和疾病中的重要性。 对细胞间连接体的研究仍然是一个充满活力的领域，因为科学家们寻求揭示更多关于其功能和潜在治疗靶点的信息。理解细胞间连接体如何运作可能导致与其功能障碍相关的疾病的创新治疗。例如，旨在增强细胞间连接体稳定性的策略可能有助于治疗与这些结构相关的皮肤疾病或心脏病。 总之，细胞间连接体不仅仅是细胞的胶水；它们是动态结构，在维持组织完整性、促进愈合过程中的沟通以及影响疾病过程方面发挥着关键作用。它们的研究不仅加深了我们对细胞结构的理解，还为医学进步开辟了途径。当我们继续探索细胞间连接体的复杂性时，我们获得了关于支配生命本身的生物学基本原则的宝贵见解。