fluorouracil

简明释义

英[flʊərəˈjʊərəsɪl]美[ˌfluːrəˈjuːrəsɪl;ˌflɔːrəˈjuː

n. 氟二氧嘧啶（一种抗癌药），[药]氟尿嘧啶

英英释义

单词用法

同义词

反义词

例句

1.METHODS An O/W emulsion-solvent evaporation method was used to prepare fluorouracil sustained release microspheres.

方法以聚乳酸为载体材料，OW型乳化挥发法制备氟尿嘧啶微球；

2.As noted, treatment with topical fluorouracil improved actinic keratoses and photoaging and most patients said they were willing to undergo treatment again.

如上所述，局部外用氟尿嘧啶乳膏能显著改善日光角化病和光老化的病情，大部分病人都愿再次接受氟尿嘧啶乳膏治疗。

3.Objective to study the release characteristics of fluorouracil-loaded carboxymethyl chitosan microspheres (Fu-CMCS-MS) in vitro.

目的探讨对以羧甲基壳聚糖为载体的氟尿嘧啶微球体外释药特性的影响因素。

4.Objective to prepare carboxymethyl chitosan microspheres of fluorouracil (FU-CMCS-MS), and measure the releasing of FU-CMCS-MS in vitro.

目的探讨羧甲基壳聚糖包药微球体的制备及体外释药特性。

5.Toxic effects of capecitabine and fluorouracil were similar.

卡培他滨和氟尿嘧啶的毒副作用相似。

6.She was given an electronic pump containing a four day dose of two chemotherapy drugs, 5-fluorouracil and cisplatin, to administer to herself at home.

医生给她开具了一种含有两种化疗药物(5 -氟尿嘧啶和顺铂)四天剂量的电子泵给药装置，在家自我注射治疗。

7.Objective To synthesize 5-fluorouracil derivatives containing 2-5 carbon alkanoic acid.

目的合成含2~5个碳的直链烷酸功能基的5-氟尿嘧啶衍生物。

8.The oncologist prescribed fluorouracil for the patient's colorectal cancer treatment.

肿瘤科医生为患者的结直肠癌治疗开了氟尿嘧啶。

9.Patients receiving fluorouracil may experience side effects such as nausea and hair loss.

接受氟尿嘧啶治疗的患者可能会经历恶心和脱发等副作用。

10.The nurse explained how fluorouracil works to inhibit cancer cell growth.

护士解释了氟尿嘧啶如何抑制癌细胞生长。

11.In combination therapy, fluorouracil is often used with other chemotherapy drugs.

在联合疗法中，氟尿嘧啶通常与其他化疗药物一起使用。

12.The patient was informed about the potential risks associated with fluorouracil treatment.

患者被告知与氟尿嘧啶治疗相关的潜在风险。

作文

Fluorouracil is a medication that has played a significant role in the treatment of various cancers, particularly in the management of colorectal cancer. As a chemotherapeutic agent, it works by interfering with the synthesis of DNA and RNA, ultimately inhibiting the growth of cancer cells. The mechanism of action of fluorouracil (氟尿嘧啶) involves the disruption of the normal function of thymidylate synthase, an enzyme critical for DNA replication. This inhibition leads to a decrease in the availability of thymidine, which is essential for DNA synthesis, thereby causing cancer cells to undergo apoptosis or programmed cell death. The administration of fluorouracil (氟尿嘧啶) can be done through various routes, including intravenous infusion or topical application. In the case of colorectal cancer, it is often used in combination with other drugs, such as leucovorin, to enhance its efficacy. Clinical studies have shown that this combination therapy can significantly improve survival rates among patients with advanced-stage cancers. Furthermore, fluorouracil (氟尿嘧啶) is also utilized in treating other types of cancers, including breast, stomach, and pancreatic cancers, showcasing its versatility as a chemotherapeutic agent. Despite its effectiveness, the use of fluorouracil (氟尿嘧啶) is not without side effects. Common adverse reactions include nausea, vomiting, diarrhea, and mucositis, which can severely impact a patient's quality of life. Additionally, some patients may experience myelosuppression, leading to a decreased production of blood cells, which increases the risk of infections and bleeding. It is crucial for healthcare providers to monitor patients closely during treatment with fluorouracil (氟尿嘧啶) and to manage any side effects that arise promptly. In recent years, there has been ongoing research aimed at improving the delivery and effectiveness of fluorouracil (氟尿嘧啶). New formulations and combinations with targeted therapies are being explored to enhance its anticancer properties while minimizing side effects. For instance, studies are investigating the use of nanoparticles to deliver fluorouracil (氟尿嘧啶) directly to tumor sites, potentially increasing local concentration and reducing systemic toxicity. This innovative approach could revolutionize how we administer chemotherapy and improve outcomes for patients. In conclusion, fluorouracil (氟尿嘧啶) remains a cornerstone in the treatment of several types of cancer. Its ability to disrupt cellular processes essential for cancer cell survival has made it a valuable tool in oncology. However, the challenges associated with its side effects and the need for personalized treatment approaches underscore the importance of continued research and development in the field of cancer therapeutics. As we advance our understanding of cancer biology and treatment modalities, fluorouracil (氟尿嘧啶) will likely continue to play a pivotal role in the fight against cancer.

氟尿嘧啶是一种在治疗各种癌症中发挥重要作用的药物，特别是在结直肠癌的管理中。作为一种化疗药物，它通过干扰DNA和RNA的合成，最终抑制癌细胞的生长。氟尿嘧啶的作用机制涉及对胸苷酸合酶这一关键酶的正常功能的破坏，该酶对DNA复制至关重要。这种抑制导致胸苷的可用性减少，而胸苷对DNA合成是必不可少的，从而使癌细胞经历凋亡或程序性细胞死亡。 氟尿嘧啶的给药可以通过多种途径进行，包括静脉输注或局部应用。在结直肠癌的情况下，它通常与其他药物（如亚叶酸）联合使用，以增强其疗效。临床研究表明，这种联合疗法可以显著提高晚期癌症患者的生存率。此外，氟尿嘧啶还用于治疗其他类型的癌症，包括乳腺癌、胃癌和胰腺癌，展示了它作为化疗药物的多样性。 尽管有效，但使用氟尿嘧啶并非没有副作用。常见的不良反应包括恶心、呕吐、腹泻和粘膜炎，这些都可能严重影响患者的生活质量。此外，一些患者可能会经历骨髓抑制，导致血细胞生成减少，从而增加感染和出血的风险。在使用氟尿嘧啶期间，医疗提供者必须密切监测患者，并及时管理出现的任何副作用。 近年来，针对改善氟尿嘧啶的递送和效果的研究不断进行。研究者们正在探索新的制剂和与靶向疗法的组合，以增强其抗癌特性，同时最小化副作用。例如，研究正在调查使用纳米颗粒直接将氟尿嘧啶递送到肿瘤部位的可能性，潜在地增加局部浓度并减少全身毒性。这种创新方法可能会彻底改变我们施用化疗的方法，并改善患者的结果。 总之，氟尿嘧啶仍然是几种类型癌症治疗的基石。它干扰癌细胞生存所必需的细胞过程的能力使其成为肿瘤学中的一项宝贵工具。然而，与其副作用相关的挑战以及个性化治疗方法的需求突显了在癌症治疗领域持续研究和发展的重要性。随着我们对癌症生物学和治疗模式的理解不断加深，氟尿嘧啶可能会继续在抗击癌症的斗争中发挥关键作用。