gangliosides

简明释义

英[ˈɡæŋɡliːəʊsaɪdz]美[ˈɡæŋɡlioʊsaɪdz]

n. [生化]神经节甘脂（ganglioside 的复数形式）

英英释义

单词用法

同义词

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例句

1.Now, a defect in the synthesis of gangliosides, glycolipids that contain sialic acid and are abundant in the brain, has been shown to underlie an inherited form of epilepsy.

现在，有研究表明，在神经节苷脂的合成过程中起作用的糖脂缺陷或者障碍，会增加遗传性癫痫的发生几率，而这种糖脂福含唾液酸并且在大脑中的含量很多。

2.Now, a defect in the synthesis of gangliosides, glycolipids that contain sialic acid and are abundant in the brain, has been shown to underlie an inherited form of epilepsy.

现在，有研究表明，在神经节苷脂的合成过程中起作用的糖脂缺陷或者障碍，会增加遗传性癫痫的发生几率，而这种糖脂福含唾液酸并且在大脑中的含量很多。

3.Methods: The gangliosides extracted from 32 samples of tumor tissues of RB and 21 control retina tissues were analyzed with high performance thin layer chromatography.

方法：应用高效薄层色谱法对32例RB瘤组织及2 1例对照视网膜组织的神经节苷脂进行对照分析。

4.Objective: to determine sialidase activity in human hepatocellular carcinoma (HCC) so as to probe into the mechanism of gangliosides change (GD3 increasing) in HCC.

目的：检测肝癌组织中唾液酸酶的活性，探讨肝癌组织中神经节苷脂谱改变(GD 3含量增加)的机理。

5.Growth factors and gangliosides are highly expressed in tumor cells, and secreted and shedded into the microenvironment of tumor cells respectively.

肿瘤细胞高表达生长因子和神经节苷脂，并将生长因子分泌到或将神经节苷脂脱落于肿瘤细胞周围的微环境中。

6.Starfish contains different types of bioactive materials, such as proteins, enzymes, steroidal glycosides, gangliosides, alkaloids etc.

海星中含有蛋白、酶、甾类糖苷、神经节苷酯、生物碱等生物活性物质。

7.Objective: to study the effects of brain gangliosides on inducing marrow stromal cells (MSCs) into neural progenitor cells.

目的：研究脑源性神经节苷脂诱导成年大鼠骨髓基质细胞定向分化为神经前体细胞的作用。

8.The results suggested that gangliosides has protective effect on the early ECoG changes of the cerebral cortical ischemia.

神经节苷脂对脑缺血引起的脑电改变具有早期保护作用。

9.Defects in the breakdown of gangliosides are associated with a class of disorders known as lysosomal storage diseases.

神经节苷脂的缺乏直接与一系列疾病有关，比如溶酶体贮积症。

10.Those in mammalian cells, the cerebrosides and gangliosides, may perform similar functions.

在哺乳动物细胞中脑磷脂和神经节苷脂可能执行同样的功能。

11.Research has shown that gangliosides 神经节苷脂 play a crucial role in cell signaling.

研究表明，神经节苷脂在细胞信号传导中起着至关重要的作用。

12.In certain neurodegenerative diseases, the metabolism of gangliosides 神经节苷脂 is disrupted.

在某些神经退行性疾病中，神经节苷脂的代谢受到干扰。

13.The presence of gangliosides 神经节苷脂 in the brain can influence neuronal development.

神经节苷脂在大脑中的存在可以影响神经元的发展。

14.Scientists are studying how gangliosides 神经节苷脂 affect synaptic transmission.

科学家们正在研究神经节苷脂如何影响突触传递。

15.Certain types of gangliosides 神经节苷脂 are involved in immune responses.

某些类型的神经节苷脂参与免疫反应。

作文

Gangliosides are complex glycosphingolipids that play crucial roles in cellular functions and signaling pathways. They are primarily found in the outer membrane of neurons and are involved in various biological processes, including cell recognition, growth, and differentiation. The structure of gangliosides is characterized by a ceramide backbone with one or more sialic acid residues attached to sugar chains. This unique composition enables gangliosides to participate in critical interactions between cells, particularly in the nervous system. One of the most fascinating aspects of gangliosides is their involvement in neurodevelopment. During brain development, gangliosides contribute to the formation of synapses, which are essential for communication between neurons. They help in the stabilization of synaptic connections and modulate neurotransmitter release, thereby influencing learning and memory processes. Research has shown that alterations in gangliosides levels can lead to neurological disorders, highlighting their importance in maintaining brain health. In addition to their role in neurodevelopment, gangliosides are also implicated in various diseases. For instance, they have been associated with neurodegenerative conditions such as Alzheimer's disease and Parkinson's disease. In these cases, abnormal accumulation or altered metabolism of gangliosides may contribute to neuronal dysfunction and cell death. Understanding the mechanisms through which gangliosides influence these diseases could pave the way for new therapeutic strategies aimed at mitigating their effects. Moreover, gangliosides have garnered attention in the field of immunology. They can act as antigens, triggering immune responses and influencing the behavior of immune cells. This property has led researchers to explore the potential of gangliosides in cancer immunotherapy. Certain types of tumors express specific gangliosides, and targeting these molecules could enhance the effectiveness of cancer treatments by facilitating immune recognition and attack on tumor cells. Despite their significance, the study of gangliosides remains challenging due to their structural complexity and the difficulty in isolating them for research purposes. However, advances in analytical techniques and molecular biology are paving the way for deeper insights into the functions and mechanisms of gangliosides. As we continue to unravel the mysteries surrounding these molecules, it is likely that we will discover even more about their roles in health and disease. In conclusion, gangliosides are vital components of cellular membranes, particularly in the nervous system, where they facilitate communication and support neurodevelopment. Their involvement in various diseases underscores the need for further research to fully understand their biological significance. By exploring the multifaceted roles of gangliosides, we can potentially unlock new avenues for treatment and prevention of neurological disorders and other health issues.

神经节苷脂是复杂的糖鞘脂，在细胞功能和信号通路中起着至关重要的作用。它们主要存在于神经元的外膜中，参与多种生物过程，包括细胞识别、增长和分化。gangliosides的结构以神经酰胺骨架为特征，附有一个或多个唾液酸残基与糖链相连。这种独特的组成使得gangliosides能够参与细胞之间的重要相互作用，特别是在神经系统中。 gangliosides最引人注目的方面之一是它们在神经发育中的作用。在大脑发育过程中，gangliosides有助于突触的形成，而突触对于神经元之间的通信至关重要。它们有助于稳定突触连接并调节神经递质的释放，从而影响学习和记忆过程。研究表明，gangliosides水平的变化可能导致神经系统疾病，突显了它们在维持大脑健康方面的重要性。 除了在神经发育中的作用外，gangliosides还与各种疾病有关。例如，它们与阿尔茨海默病和帕金森病等神经退行性疾病有关。在这些情况下，gangliosides的异常积累或代谢改变可能导致神经元功能障碍和细胞死亡。理解gangliosides影响这些疾病的机制可能为新疗法的开发铺平道路，旨在减轻其影响。 此外，gangliosides在免疫学领域也引起了关注。它们可以作为抗原，触发免疫反应并影响免疫细胞的行为。这一特性使得研究人员探索gangliosides在癌症免疫治疗中的潜力。某些类型的肿瘤表达特定的gangliosides，靶向这些分子可能通过促进免疫识别和攻击肿瘤细胞来增强癌症治疗的有效性。 尽管gangliosides的重要性不言而喻，但由于其结构复杂以及难以分离用于研究，研究仍然面临挑战。然而，分析技术和分子生物学的进步正在为深入了解gangliosides的功能和机制铺平道路。随着我们继续揭开围绕这些分子的神秘面纱，我们可能会发现更多关于它们在健康和疾病中的作用。 总之，gangliosides是细胞膜的重要组成部分，尤其是在神经系统中，它们促进通信并支持神经发育。它们在各种疾病中的参与强调了进一步研究的必要性，以充分理解它们的生物学意义。通过探索gangliosides的多方面角色，我们可能会打开新的治疗和预防神经系统疾病及其他健康问题的途径。