gentamicin

简明释义

英[dʒentəˈmaɪsɪn]美[ˌdʒentəˈmaɪsɪn]

n. [药] 庆大霉素；艮他霉素

英英释义

单词用法

同义词

反义词

例句

1.Objective to discuss the foundation of the animal model of gentamicin-induced toxic acute tubular necrosis and approach its value scientific research.

目的探讨庆大霉素诱发的中毒性急性肾小管坏死动物模型的建立，研究其在基础及临床科研中的价值。

2.Objective To explore a new kind of bone graft (gentamicin compound bone), which can have a local anti infective function, low immunogenicity and high osteogenesis.

目的研制一种既有成骨作用又有局部抗感染能力，且有较低免疫原性的新型高效骨植入材料。

3.Objective to discuss the effects of gentamicin nephrotoxicity on the apoptosis of proximal tubule epithelial cells of rats.

目的探讨庆大霉素对实验性大鼠肾近端小管上皮细胞凋亡的影响。

4.OBJECTIVE: To study the mechanism of Panaxadiol saponins (PDS) in treating renal injury induced by Gentamicin (GM).

目的：研究人参二醇组皂苷(PDS)减轻庆大霉素(gm)性肾损伤的机制。

5.Objective: To study the protective effect of Gujingdan on the acute renal failure caused by gentamicin in rats.

目的：研究中药复方固精丹对庆大霉素致大鼠急性肾功能衰竭的保护作用。

6.Western medicine: Saltpetre thread of placental tissue fluid, gentamicin, compound, armour wow, 50 % dextrose fluid.

西药：胎盘组织液、庆大霉素、复方黄连素、甲硝哇、50%葡萄糖液等。

7.Conclusion Huangqi and isoptin may play a role in the protection of nephrotoxicity induced by gentamicin.

结论黄芪、异博定对庆大霉素肾毒性有保护作用。

8.The doctor prescribed gentamicin for the patient's severe bacterial infection.

医生为患者的严重细菌感染开了氨基糖苷类抗生素。

9.Before administering gentamicin, the nurse checked the patient's kidney function.

在给患者注射氨基糖苷类抗生素之前，护士检查了患者的肾功能。

10.The laboratory results showed that the bacteria were sensitive to gentamicin.

实验室结果显示细菌对氨基糖苷类抗生素敏感。

11.Patients receiving gentamicin should be monitored for possible side effects.

接受氨基糖苷类抗生素治疗的患者应监测可能的副作用。

12.In cases of resistant infections, gentamicin may be used in combination with other antibiotics.

在耐药性感染的情况下，氨基糖苷类抗生素可能与其他抗生素联合使用。

作文

Gentamicin is an antibiotic that belongs to the aminoglycoside class of antibiotics. It is primarily used to treat various types of bacterial infections, particularly those caused by gram-negative bacteria. The discovery of gentamicin in the early 1960s marked a significant advancement in the field of medicine, as it provided an effective treatment option for serious infections that were resistant to other antibiotics. Gentamicin is often administered intravenously or intramuscularly, making it suitable for severe infections that require immediate and potent treatment. One of the key characteristics of gentamicin is its mechanism of action. It works by binding to the bacterial ribosome, inhibiting protein synthesis, which ultimately leads to cell death. This makes gentamicin particularly effective against a wide range of pathogens, including Pseudomonas aeruginosa, Escherichia coli, and Klebsiella species. However, it is important to note that gentamicin is not effective against all bacteria, and its use should be guided by susceptibility testing to ensure that the targeted bacteria are sensitive to the drug. The use of gentamicin comes with certain risks and side effects, the most notable being nephrotoxicity and ototoxicity. Nephrotoxicity refers to the potential damage to the kidneys, while ototoxicity can lead to hearing loss or balance issues. Therefore, healthcare providers must carefully monitor patients receiving gentamicin, especially those with pre-existing kidney conditions or those taking other medications that may exacerbate these side effects. In clinical practice, gentamicin is often used in combination with other antibiotics to enhance its efficacy and broaden the spectrum of activity. This approach is particularly useful in treating polymicrobial infections, where multiple types of bacteria are present. For instance, in cases of sepsis or complicated urinary tract infections, combining gentamicin with beta-lactam antibiotics can provide a more comprehensive treatment strategy. Despite its effectiveness, the emergence of antibiotic resistance poses a significant challenge in the use of gentamicin. Bacteria can develop mechanisms to resist the effects of the drug, leading to treatment failures. This underscores the importance of using gentamicin judiciously and only when necessary. Healthcare professionals are encouraged to adhere to guidelines that promote appropriate antibiotic use, including de-escalation strategies once culture results are available. In conclusion, gentamicin is a powerful antibiotic that has played a crucial role in combating bacterial infections. Its ability to target a broad range of pathogens makes it a valuable tool in modern medicine. However, the associated risks and the threat of antibiotic resistance necessitate careful consideration and monitoring during its use. As we continue to navigate the complexities of infectious diseases, understanding and appropriately utilizing gentamicin will remain essential in ensuring effective patient care and improving health outcomes.

庆大霉素是一种属于氨基糖苷类抗生素的药物。它主要用于治疗各种类型的细菌感染，尤其是由革兰氏阴性细菌引起的感染。庆大霉素在20世纪60年代初的发现标志着医学领域的一项重大进展，因为它为严重感染提供了有效的治疗选择，这些感染对其他抗生素具有耐药性。庆大霉素通常通过静脉注射或肌肉注射给药，使其适合于需要立即和强效治疗的严重感染。 庆大霉素的一个关键特征是其作用机制。它通过结合细菌核糖体抑制蛋白质合成，最终导致细胞死亡。这使得庆大霉素对多种病原体特别有效，包括铜绿假单胞菌、大肠杆菌和克雷伯菌属。然而，重要的是要注意，庆大霉素并不对所有细菌有效，其使用应根据敏感性检测来指导，以确保靶向细菌对该药物敏感。 使用庆大霉素存在一定的风险和副作用，其中最显著的是肾毒性和耳毒性。肾毒性指的是对肾脏的潜在损害，而耳毒性可能导致听力丧失或平衡问题。因此，医疗提供者必须仔细监测接受庆大霉素治疗的患者，尤其是那些有既往肾脏疾病或正在服用可能加剧这些副作用的其他药物的患者。 在临床实践中，庆大霉素常常与其他抗生素联合使用，以增强其疗效并扩大活性谱。这种方法在治疗多种微生物感染时尤其有用，在这种情况下，存在多种类型的细菌。例如，在败血症或复杂尿路感染的病例中，将庆大霉素与β-内酰胺类抗生素结合使用可以提供更全面的治疗策略。 尽管庆大霉素有效，但抗生素耐药性的出现对其使用构成了重大挑战。细菌可能会发展出抵抗药物的机制，导致治疗失败。这突显了明智使用庆大霉素和仅在必要时使用的重要性。医疗专业人员被鼓励遵循促进适当抗生素使用的指南，包括在获得培养结果后进行减药策略。 总之，庆大霉素是一种强效抗生素，在对抗细菌感染方面发挥了至关重要的作用。它针对广泛病原体的能力使其成为现代医学中的宝贵工具。然而，相关的风险和抗生素耐药性的威胁要求在使用过程中进行仔细考虑和监测。随着我们继续应对传染病的复杂性，理解和适当地利用庆大霉素将继续在确保有效的患者护理和改善健康结果方面至关重要。