glucokinase

简明释义

英[ˌɡluːkəʊˈkaɪneɪz]美[ɡluːkoʊˈkaɪneɪs]

n. [生化] 葡糖激酶

英英释义

单词用法

同义词

反义词

例句

1.Compared with the Saline control groups, the gene expression of glucokinase in the liver on model rats of the senna leaf laxation group remarkably decrease (P<0. 01).

肝脏中葡萄糖激酶基因表达情况：番泻叶泻下脾气虚组大鼠肝脏中葡萄糖激酶鑫因表达与生理盐水对照组比较显著降低（P<0 .01）。

2.Compared with the Saline control groups, the gene expression of glucokinase in the liver on model rats of the senna leaf laxation group remarkably decrease (P<0. 01).

肝脏中葡萄糖激酶基因表达情况：番泻叶泻下脾气虚组大鼠肝脏中葡萄糖激酶鑫因表达与生理盐水对照组比较显著降低（P<0 .01）。

3.An experimental diabetes model was produced by intraperitoneal injection of alloxan. Blood glucose, liver glucokinase and liver glycogen contents were measured.

通过腹腔注射四氧嘧啶造小鼠糖尿病模型，观察血糖、肝糖原、葡萄糖激酶等指标。

4.Thus, it acts in a complementary mechanism to GKRP, which also regulates glucokinase protein expression and compartmentation .

这样，它对于GKRP的作用是一种补充机制， GKRP也调节葡萄糖激酶蛋白的表达和区间作用。

5.Objective To evaluate the role of glucokinase(GCK) gene in the pathogenesis of gestational diabetes mellitus(GDM) in Chinese.

目的探讨葡萄糖激酶（GCK）基因与妊娠糖尿病（GDM）易感性的关系。

6.Pyridin-2 -yl-amino-1, 2, 4 -thiadiazole derivatives as glucokinase activators for the treatment of diabetes mellitus.

用于治疗糖尿病的、作为葡糖激酶激活剂的吡啶-2-基-氨基-1，2，4-噻二唑衍生物。

7.The present invention discloses one new type of low toxicity glucokinase mutant and its preparation process and use.

本发明公开了一种新型低毒性葡激酶突变体，还公开了其制备方法及用 途。

8.Prevalence of vascular complications among patients with glucokinase mutations and prolonged, mild hyperglycemia.

【译】与葡萄糖激酶基因突变和延长患者的血管并发症的患病率，轻度高血糖。

9.The content of liver glycogen and the activity of liver glucokinase were studied.

实验结束后取肝脏测定糖原含量和葡萄糖激酶活性。

10.The role of glucokinase in glucose metabolism is crucial for maintaining normal blood sugar levels.

葡萄糖激酶在葡萄糖代谢中的作用对于维持正常血糖水平至关重要。

11.Patients with diabetes may have a deficiency in glucokinase, affecting their ability to regulate insulin.

糖尿病患者可能缺乏葡萄糖激酶，影响他们调节胰岛素的能力。

12.Research shows that enhancing glucokinase activity can improve glucose tolerance.

研究表明，增强葡萄糖激酶活性可以改善葡萄糖耐受性。

13.Certain drugs target glucokinase to help manage blood sugar levels in diabetic patients.

某些药物针对葡萄糖激酶以帮助管理糖尿病患者的血糖水平。

14.The liver uses glucokinase to convert excess glucose into glycogen for storage.

肝脏利用葡萄糖激酶将多余的葡萄糖转化为糖原以储存。

作文

Glucokinase is an essential enzyme that plays a crucial role in glucose metabolism. It is primarily found in the liver and pancreatic beta cells, where it facilitates the conversion of glucose into glucose-6-phosphate, a key step in the glycolytic pathway. This process is vital for maintaining normal blood sugar levels and providing energy to cells throughout the body. Understanding the function of glucokinase (葡萄糖激酶) can help us appreciate its importance in metabolic health and disease. One of the unique features of glucokinase (葡萄糖激酶) is its regulatory mechanism. Unlike other hexokinases, glucokinase (葡萄糖激酶) has a high Km value for glucose, which means it only becomes active when glucose levels are elevated, such as after a meal. This property allows the enzyme to act as a glucose sensor, ensuring that the liver only processes excess glucose when it is available. Consequently, this helps prevent hypoglycemia, a condition characterized by dangerously low blood sugar levels. The activity of glucokinase (葡萄糖激酶) is influenced by various factors, including hormonal regulation and allosteric effects. Insulin, for instance, promotes the expression of glucokinase (葡萄糖激酶) in the liver, enhancing its activity after meals. On the other hand, glucagon, another hormone produced by the pancreas, inhibits its function, thus regulating the balance of glucose in the bloodstream. This intricate interplay between hormones and glucokinase (葡萄糖激酶) highlights the enzyme's critical role in glucose homeostasis. In addition to its physiological functions, glucokinase (葡萄糖激酶) has garnered attention in the context of diabetes research. Impaired glucokinase (葡萄糖激酶) function can lead to dysregulation of glucose levels, contributing to hyperglycemia, a hallmark of diabetes. Therefore, glucokinase (葡萄糖激酶) has been identified as a potential target for therapeutic interventions aimed at improving glycemic control in diabetic patients. Some studies have explored the development of glucokinase (葡萄糖激酶) activators as a novel class of medications that could enhance insulin sensitivity and promote better glucose uptake in tissues. Moreover, genetic variations in the glucokinase (葡萄糖激酶) gene can influence an individual's risk of developing type 2 diabetes. Certain mutations may lead to a reduced ability of the enzyme to respond to glucose, resulting in impaired insulin secretion and increased blood sugar levels. Understanding these genetic factors can provide insights into personalized medicine approaches for diabetes management. In conclusion, glucokinase (葡萄糖激酶) is a vital enzyme that plays a significant role in glucose metabolism and homeostasis. Its unique properties, regulatory mechanisms, and implications in diabetes make it a fascinating subject of study in biochemistry and medicine. As research continues to unravel the complexities of glucokinase (葡萄糖激酶), we gain a deeper understanding of its potential as a therapeutic target and its significance in maintaining metabolic health.