glycosylation

简明释义

英[ˌɡlaɪkəsəˈleɪʃən]美[ɡlaɪkəsɪˈleɪʃən]

n. 糖基化

英英释义

单词用法

同义词

反义词

例句

1.Excessive glycosylation appears to be one of the causes of the organ damage that occurs in diabetes.

过多的糖基化似乎对器官损害，在糖尿病发生的原因之一。

2.Sugar nucleotides are sugar donors to aglycone in glycosylation, which is catalyzed by glycosyltransferases.

它是通过糖基转移酶催化完成的，其中糖核苷酸是糖基化过程中糖的供体。

3.Oxidation of LDL promoted by glycosylation is one of important pathogenesis of AS formation in DM2 patients.

糖化促进氧化是2型DM病人发生AS的重要发病机制之一。

4.Objective: To separate two oligosaccharide isomers which have very similar polarity and to try a new method of glycosylation.

目的：分离两种极性极为相似的寡糖异构体并对一种新的糖基化方法进行初步探索。

5.Objective: to investigate the inhibitory effects of some Chinese herb components on the nonenzymatic glycosylation.

目的：研究某些中药有效成分对非酶糖基化的抑制作用。

6.These data suggest that nonenzymatic glycosylation of lens crystallins may contribute to cataract formation.

这些数据表明晶状体蛋白的非酶糖基化可能会导致白内障。

7.Conclusion: GSPE can inhibit nonenzymatic reactions of glycosylation in STZ-induced diabetic rats and protect the myocardial ultra-structure.

结论：GSPE能够抑制STZ糖尿病大鼠非酶糖基化反应，对其心脏超微结构有一定保护作用。

8.The process of glycosylation is crucial for the proper functioning of many proteins.

过程中的糖基化对于许多蛋白质的正常功能至关重要。

9.Researchers are studying how glycosylation affects cell signaling pathways.

研究人员正在研究糖基化如何影响细胞信号传导通路。

10.Abnormal glycosylation patterns can lead to various diseases, including cancer.

异常的糖基化模式可能导致各种疾病，包括癌症。

11.The pharmaceutical industry often examines glycosylation when developing new drugs.

制药行业在开发新药时通常会考察糖基化。

12.Enzymes involved in glycosylation play a key role in cellular metabolism.

参与糖基化的酶在细胞代谢中发挥着关键作用。

作文

Glycosylation is a vital biochemical process that plays a significant role in the functioning of living organisms. This process involves the addition of carbohydrate moieties, or glycans, to proteins or lipids, which can profoundly affect their structure and function. Understanding glycosylation (糖基化) is crucial for various fields, including biochemistry, molecular biology, and medicine. One of the most important aspects of glycosylation (糖基化) is its impact on protein folding and stability. When a carbohydrate is attached to a protein, it can help the protein achieve its proper three-dimensional shape, which is essential for its biological activity. Misfolded proteins can lead to diseases such as Alzheimer's and Parkinson's, highlighting the importance of glycosylation (糖基化) in maintaining cellular health. Moreover, glycosylation (糖基化) also plays a critical role in cell signaling and communication. Glycoproteins, which are proteins that have undergone glycosylation (糖基化), are often involved in signaling pathways that regulate various physiological processes. For instance, the immune response relies heavily on glycoproteins to recognize pathogens and initiate an immune reaction. Therefore, understanding how glycosylation (糖基化) affects these proteins can provide insights into how our bodies defend against diseases. Additionally, glycosylation (糖基化) is essential for the development of therapeutic proteins. Many biopharmaceuticals, such as monoclonal antibodies, require specific glycosylation patterns to be effective. The presence or absence of certain glycans can influence the efficacy and safety of these drugs. As a result, biotechnologists must carefully control glycosylation (糖基化) during the production of these therapeutic proteins to ensure they perform as intended. In recent years, advances in technology have allowed scientists to study glycosylation (糖基化) in greater detail. Techniques such as mass spectrometry and high-performance liquid chromatography (HPLC) enable researchers to analyze glycan structures and their functions. This has led to a better understanding of how different glycosylation patterns can affect disease progression and treatment outcomes. Furthermore, the study of glycosylation (糖基化) has opened new avenues for drug development. Researchers are exploring ways to manipulate glycosylation (糖基化) pathways to create novel therapeutics that can target specific diseases more effectively. For example, modifying the glycosylation of cancer drugs could enhance their ability to target tumor cells while minimizing side effects on healthy tissues. In conclusion, glycosylation (糖基化) is a fundamental biological process with far-reaching implications for health and disease. Its influence on protein function, cell signaling, and drug development underscores the importance of understanding this complex modification. As research continues to uncover the intricacies of glycosylation (糖基化), we can anticipate exciting advancements in biotechnology and medicine that will improve our ability to treat various diseases and enhance human health.

糖基化是一个重要的生化过程，在生物体的功能中发挥着重要作用。这个过程涉及将碳水化合物部分或糖链附加到蛋白质或脂质上，这可以深刻影响它们的结构和功能。理解glycosylation（糖基化）对于生物化学、分子生物学和医学等多个领域至关重要。 glycosylation（糖基化）最重要的方面之一是它对蛋白质折叠和稳定性的影响。当一个碳水化合物附加到一个蛋白质上时，它可以帮助该蛋白质达到其适当的三维形状，这对其生物活性至关重要。错误折叠的蛋白质可能导致阿尔茨海默病和帕金森病等疾病，这突显了glycosylation（糖基化）在维持细胞健康中的重要性。 此外，glycosylation（糖基化）在细胞信号传递和沟通中也发挥着关键作用。糖蛋白，即经历过glycosylation（糖基化）的蛋白质，通常参与调节各种生理过程的信号通路。例如，免疫反应在很大程度上依赖于糖蛋白来识别病原体并启动免疫反应。因此，了解glycosylation（糖基化）如何影响这些蛋白质，可以为我们提供有关身体如何抵御疾病的见解。 此外，glycosylation（糖基化）对治疗性蛋白质的发展至关重要。许多生物制药，如单克隆抗体，需要特定的糖基化模式才能有效。这些药物中某些糖链的存在或缺失可能会影响其疗效和安全性。因此，生物技术专家必须在生产这些治疗性蛋白质的过程中仔细控制glycosylation（糖基化），以确保它们按预期发挥作用。 近年来，技术的进步使科学家能够更详细地研究glycosylation（糖基化）。质谱法和高效液相色谱法（HPLC）等技术使研究人员能够分析糖链结构及其功能。这导致了对不同糖基化模式如何影响疾病进展和治疗结果的更好理解。 此外，glycosylation（糖基化）的研究为药物开发开辟了新的途径。研究人员正在探索操纵glycosylation（糖基化）途径的方法，以创造能够更有效地靶向特定疾病的新型治疗药物。例如，改变癌症药物的糖基化可能增强其靶向肿瘤细胞的能力，同时最大限度地减少对健康组织的副作用。 总之，glycosylation（糖基化）是一个基本的生物过程，对健康和疾病具有深远的影响。它对蛋白质功能、细胞信号传递和药物开发的影响突显了理解这一复杂修饰的重要性。随着研究继续揭示glycosylation（糖基化）的复杂性，我们可以期待生物技术和医学领域令人兴奋的进展，这将改善我们治疗各种疾病和增强人类健康的能力。