gyrase

简明释义

英[ˈdʒaɪreɪz]美[ˈdʒaɪreɪs]

n. [生化] 旋转酶，促旋酶

英英释义

单词用法

同义词

反义词

例句

1.It can affect the function of DNA gyrase in bacteria, which results in the inhibition of the duplication and transformation of DNA.

左氧氟沙星可通过作用于细菌的脱氧核糖核酸旋转酶，抑制细菌DNA的复制和转换，发挥广谱抗菌作用。

2.It can affect the function of DNA gyrase in bacteria, which results in the inhibition of the duplication and transformation of DNA.

左氧氟沙星可通过作用于细菌的脱氧核糖核酸旋转酶，抑制细菌DNA的复制和转换，发挥广谱抗菌作用。

3.OBJECTIVE to study the mutation in DNA gyrase a of Escherichia coli resistante to quinolone antibiotics.

目的研究导致大肠埃希菌dna回旋酶a亚单位的基因变异耐喹诺酮类药物的机制。

4.The enzyme gyrase is crucial for DNA replication.

酶旋转酶对于DNA复制至关重要。

5.Inhibiting gyrase can prevent bacterial growth.

抑制旋转酶可以防止细菌生长。

6.Researchers are studying the role of gyrase in antibiotic resistance.

研究人员正在研究旋转酶在抗生素耐药性中的作用。

7.The mechanism of action of gyrase involves introducing negative supercoils into DNA.

旋转酶的作用机制涉及在DNA中引入负超螺旋。

8.Mutations in the gyrase gene can lead to severe genetic disorders.

旋转酶基因的突变可能导致严重的遗传疾病。

作文

The enzyme known as gyrase plays a crucial role in the process of DNA replication and transcription. In simple terms, gyrase is a type of topoisomerase that introduces negative supercoils into DNA. This action is essential because it helps to relieve the torsional strain that builds up ahead of the replication fork during DNA unwinding. Without gyrase, the DNA strands would become overly twisted, making it difficult for the replication machinery to function properly. In bacteria, gyrase is particularly important as it is one of the few enzymes capable of introducing negative supercoils. This unique ability allows bacterial cells to efficiently manage their DNA under various conditions, especially when they are rapidly dividing. The significance of gyrase extends beyond just bacterial physiology; it has also become a target for antibiotic development. Drugs such as quinolones inhibit gyrase, effectively stopping bacterial growth by preventing proper DNA replication. This highlights the enzyme's importance not only in basic biological processes but also in medical applications. Moreover, the study of gyrase provides insights into the fundamental mechanisms of DNA manipulation. Researchers have been able to observe how gyrase interacts with DNA, leading to a better understanding of the dynamics of genetic material. It is fascinating to see how this enzyme can alter the structure of DNA, impacting gene expression and cellular function. The implications of understanding gyrase are vast, ranging from biotechnology to synthetic biology, where scientists aim to engineer organisms with specific traits. Additionally, the mechanism by which gyrase operates is intricate and involves several steps. First, gyrase binds to the DNA strand, creating a break in one of the strands. Then, it passes another segment of the DNA through this break before resealing it. This process not only introduces negative supercoils but also ensures that the DNA remains stable and functional. The efficiency of gyrase is vital for maintaining the integrity of the genetic information, which is essential for life. In conclusion, gyrase is more than just an enzyme; it is a key player in the molecular dance of DNA management. Its role in facilitating DNA replication and its potential as a target for antibiotics underscore its significance in both biology and medicine. As research continues to unveil the complexities of gyrase and its interactions with DNA, we gain a deeper appreciation for the elegance of cellular processes and the potential for innovative therapeutic strategies. Understanding gyrase not only enhances our knowledge of fundamental biological principles but also opens new avenues for scientific exploration and discovery.

被称为gyrase的酶在DNA复制和转录过程中发挥着至关重要的作用。简单来说，gyrase是一种拓扑异构酶，能够在DNA中引入负超螺旋。这一作用是必要的，因为它有助于缓解在DNA解开过程中，复制叉前方积累的扭转应变。如果没有gyrase，DNA链会变得过于扭曲，从而使复制机制难以正常运作。 在细菌中，gyrase尤其重要，因为它是少数几种能够引入负超螺旋的酶之一。这一独特的能力使细菌细胞能够有效地管理其DNA，尤其是在快速分裂时。gyrase的重要性不仅体现在细菌生理学上；它还成为抗生素开发的目标。像氟喹诺酮这样的药物抑制gyrase，通过阻止DNA复制有效地停止细菌生长。这突显了该酶在基本生物过程和医疗应用中的重要性。 此外，对gyrase的研究提供了对DNA操作基本机制的深入了解。研究人员能够观察到gyrase如何与DNA相互作用，从而更好地理解遗传物质的动态。看到这种酶如何改变DNA的结构，影响基因表达和细胞功能，真是令人着迷。理解gyrase的意义广泛，涉及从生物技术到合成生物学等领域，科学家们旨在工程化具有特定特征的生物体。 此外，gyrase的工作机制复杂，涉及多个步骤。首先，gyrase与DNA链结合，在其中一条链上产生断裂。然后，它通过这个断裂部分将另一段DNA穿过，最后重新封闭。这一过程不仅引入了负超螺旋，还确保DNA保持稳定和功能。gyrase的效率对于维持遗传信息的完整性至关重要，这对生命至关重要。 总之，gyrase不仅仅是一种酶；它是DNA管理分子舞蹈中的关键参与者。它在促进DNA复制中的作用以及作为抗生素靶点的潜力突显了它在生物学和医学中的重要性。随着研究不断揭示gyrase及其与DNA相互作用的复杂性，我们对细胞过程的优雅性和创新治疗策略的潜力有了更深的理解。理解gyrase不仅提升了我们对基本生物原则的认识，还为科学探索和发现开辟了新的途径。