hexokinase

简明释义

英[ˌheksəʊˈkaɪneɪs]美[heksoʊˈkaɪneɪs;ˌheksəˈkaɪneɪ

n. [生化] 己糖激酶

英英释义

单词用法

同义词

反义词

例句

1.Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the sequence of human hexokinase I. antibodies are purified by peptide affinity chromatography.

该多克隆抗体用与人类己糖激酶i氨基酸序列对应的人工合成肽段免疫动物制成。该抗体使用蛋白a和肽亲和层析纯化制得。

2.Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the sequence of human hexokinase I. antibodies are purified by peptide affinity chromatography.

该多克隆抗体用与人类己糖激酶i氨基酸序列对应的人工合成肽段免疫动物制成。该抗体使用蛋白a和肽亲和层析纯化制得。

3.Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to the sequence of human hexokinase I.

该单克隆抗体用与人类己糖激酶i蛋白氨基酸序列对应的人工合成肽段免疫动物而制成。

4.In recent years, there has been already more research work about the hexokinase of plants and got enough attention.

近年来，有关植物己糖激酶的研究工作已经较多，受到足够的重视。

5.Hexokinase I (C35C4) Rabbit mAb detects endogenous levels of total hexokinase I protein.

兔单克隆抗体识别内源性的全部己糖激酶i蛋白水平。

6.Hexokinase I Antibody detects endogenous levels of total hexokinase I protein.

己糖激酶i抗体识别内源性的己糖激酶i总蛋白水平。

7.Hexokinase is an important enzyme in the metabolism of glucose by cells.

己糖激酶是细胞代谢葡萄糖的一个重要的酶。

8.The enzyme hexokinase plays a crucial role in the glycolysis pathway.

酶己糖激酶在糖酵解途径中起着至关重要的作用。

9.Increased levels of hexokinase can indicate high glucose metabolism.

增加的己糖激酶水平可能表明高葡萄糖代谢。

10.Researchers are studying how hexokinase affects cancer cell growth.

研究人员正在研究己糖激酶如何影响癌细胞生长。

11.The activity of hexokinase is regulated by several metabolites.

多个代谢物调节己糖激酶的活性。

12.Mutations in the hexokinase gene can lead to metabolic disorders.

在己糖激酶基因中的突变可能导致代谢紊乱。

作文

Hexokinase is an essential enzyme found in many organisms, playing a crucial role in the metabolism of glucose. This enzyme catalyzes the phosphorylation of glucose to form glucose-6-phosphate, which is the first step in the glycolytic pathway. The importance of hexokinase (己糖激酶) cannot be overstated, as it not only initiates the breakdown of glucose for energy production but also acts as a regulatory point for glucose metabolism. In human physiology, hexokinase (己糖激酶) exists in several isoforms, each with distinct kinetic properties and tissue distributions. For instance, hexokinase (己糖激酶) type I is predominantly found in muscle and fat tissues, while type IV, also known as glucokinase, is primarily present in the liver and pancreatic beta cells. This diversity allows different tissues to regulate glucose uptake according to their metabolic needs. The activity of hexokinase (己糖激酶) is influenced by various factors, including the concentration of glucose and ATP, the energy currency of the cell. When glucose levels are high, hexokinase (己糖激酶) is activated to facilitate its conversion into glucose-6-phosphate, thus promoting energy production through glycolysis or storage as glycogen. Conversely, when glucose levels are low, the activity of hexokinase (己糖激酶) decreases, preventing excessive depletion of glucose reserves. Moreover, hexokinase (己糖激酶) serves as a key regulatory enzyme in cellular signaling pathways. For example, the accumulation of glucose-6-phosphate can inhibit further activity of hexokinase (己糖激酶), creating a feedback mechanism that helps maintain glucose homeostasis. This regulation is vital for preventing conditions such as hyperglycemia, which can lead to diabetes and other metabolic disorders. Research has shown that alterations in hexokinase (己糖激酶) activity are associated with various diseases. In cancer cells, for instance, the expression of certain isoforms of hexokinase (己糖激酶) is often upregulated, facilitating rapid growth and proliferation by ensuring a constant supply of energy. This phenomenon is known as the Warburg effect, where cancer cells preferentially utilize glycolysis for energy production even in the presence of oxygen. Understanding the function and regulation of hexokinase (己糖激酶) is crucial for developing therapeutic strategies for metabolic diseases. Inhibitors targeting hexokinase (己糖激酶) have been explored as potential treatments for cancer, as they could disrupt the energy supply to rapidly dividing tumor cells. Additionally, enhancing hexokinase (己糖激酶) activity in insulin-sensitive tissues may offer a novel approach to managing diabetes. In conclusion, hexokinase (己糖激酶) is a vital enzyme that plays a significant role in glucose metabolism and energy production. Its regulatory functions and involvement in various diseases highlight the importance of understanding this enzyme at both the biochemical and clinical levels. Continued research on hexokinase (己糖激酶) will undoubtedly provide further insights into its mechanisms and potential therapeutic applications, ultimately contributing to improved health outcomes.

己糖激酶是一种存在于许多生物体中的重要酶，在葡萄糖的代谢中发挥着关键作用。该酶催化葡萄糖的磷酸化，形成葡萄糖-6-磷酸，这是糖酵解途径的第一步。hexokinase（己糖激酶）的重要性不容小觑，因为它不仅启动了葡萄糖的分解以产生能量，还充当葡萄糖代谢的调节点。 在人体生理学中，hexokinase（己糖激酶）存在几种亚型，每种亚型具有不同的动力学特性和组织分布。例如，hexokinase（己糖激酶）I型主要存在于肌肉和脂肪组织中，而IV型，也称为葡萄糖激酶，主要存在于肝脏和胰腺β细胞中。这种多样性使得不同组织能够根据其代谢需求调节葡萄糖的摄取。 hexokinase（己糖激酶）的活性受到多种因素的影响，包括葡萄糖和ATP的浓度，ATP是细胞的能量货币。当葡萄糖水平较高时，hexokinase（己糖激酶）被激活以促进其转化为葡萄糖-6-磷酸，从而通过糖酵解促进能量的产生或作为糖原储存。相反，当葡萄糖水平较低时，hexokinase（己糖激酶）的活性降低，防止葡萄糖储备的过度消耗。 此外，hexokinase（己糖激酶）在细胞信号传导通路中也起着关键的调节作用。例如，葡萄糖-6-磷酸的积累可以抑制进一步的hexokinase（己糖激酶）活性，形成反馈机制，有助于维持葡萄糖稳态。这种调节对于防止高血糖等疾病至关重要，高血糖可能导致糖尿病和其他代谢障碍。 研究表明，hexokinase（己糖激酶）活性的变化与各种疾病相关。在癌细胞中，例如，某些亚型的hexokinase（己糖激酶）表达通常上调，通过确保持续的能量供应来促进快速生长和增殖。这种现象被称为沃伯格效应，即癌细胞即使在氧气存在的情况下也优先利用糖酵解进行能量生产。 理解hexokinase（己糖激酶）的功能和调节对于开发代谢疾病的治疗策略至关重要。针对hexokinase（己糖激酶）的抑制剂已被探索作为癌症的潜在治疗方法，因为它们可以破坏快速增殖肿瘤细胞的能量供应。此外，增强胰岛素敏感组织中hexokinase（己糖激酶）活性可能为管理糖尿病提供一种新颖的方法。 总之，hexokinase（己糖激酶）是一种在葡萄糖代谢和能量生产中发挥重要作用的关键酶。它的调节功能和与各种疾病的关系突显了在生化和临床层面理解这种酶的重要性。对hexokinase（己糖激酶）的持续研究无疑将进一步深入了解其机制和潜在的治疗应用，最终有助于改善健康结果。