isoenzymes

简明释义

英[ˌaɪsəʊˈɛnzaɪmz]美[ˌaɪsoʊˈɛnzaɪmz]

n. 异酵素；同功酶（isoenzyme 的复数形式）

英英释义

单词用法

同义词

反义词

例句

1.Two animal models were established in this experiment to investigate the relationships between muscle damage and plasma activity of CK and its isoenzymes of rats after different modes of exercise.

为了探索大鼠完成不同方式的运动后骨骼肌损伤与血浆CK及其同工酶变化的关系，本研究采用了两种动物模型。

2.Objective To study the value of GPDA and its isoenzymes as well as ADA in the differential diagnosis of ascites.

目的研究联合检测甘氨酰脯氨酸二肽氨基肽酶（GPDA）及其同工酶、腺苷脱氨酶（ADA）对不同性质腹水的鉴别诊断价值。

3.The electrophoresis technology of isoenzymes has been used comprehensively in crop genetic breeding.

同工酶电泳出现以后，在遗传育种中得到了广泛应用。

4.Two animal models were established in this experiment to investigate the relationships between muscle damage and plasma activity of CK and its isoenzymes of rats after different modes of exercise.

为了探索大鼠完成不同方式的运动后骨骼肌损伤与血浆CK及其同工酶变化的关系，本研究采用了两种动物模型。

5.The results showed that the soluble proteins and isoenzymes, there are same band with, but the quantity of band and activity of enzymes with different intensity;

结果表明，各样品的蛋白质、同工酶酶谱有共有带，但酶带数量与活性强度有差异；

6.The serum myocardial enzymes and isoenzymes activities were measured in 65 bum patients.

作者观察了65例烧伤病人血清心肌酶谱的变化。

7.The study revealed that different tissues produce distinct types of isoenzymes (同工酶) that can be used for diagnostic purposes.

研究显示，不同组织产生不同类型的isoenzymes（同工酶），可用于诊断目的。

8.Measuring the levels of isoenzymes (同工酶) in the blood can help identify specific diseases.

测量血液中isoenzymes（同工酶）的水平可以帮助识别特定疾病。

9.Certain isoenzymes (同工酶) are more active in the presence of specific substrates.

某些isoenzymes（同工酶）在特定底物存在时更为活跃。

10.Research on isoenzymes (同工酶) has led to advancements in enzyme therapy.

对isoenzymes（同工酶）的研究推动了酶治疗的发展。

11.The genetic variation in isoenzymes (同工酶) can provide insights into population genetics.

在isoenzymes（同工酶）中的遗传变异可以提供对群体遗传学的见解。

作文

Isoenzymes, also known as isoforms or enzyme variants, are different forms of an enzyme that catalyze the same chemical reaction but differ in structure and kinetic properties. These variations can arise from genetic differences, post-translational modifications, or alternative splicing of mRNA. Understanding isoenzymes (同工酶) is crucial in various fields, particularly in biochemistry and medicine, as they play significant roles in metabolic pathways and can influence the effectiveness of drugs. For instance, consider the lactate dehydrogenase (LDH) enzyme, which exists in several isoenzymes (同工酶) that are expressed in different tissues such as the heart, liver, and muscle. Each isoenzyme (同工酶) has a unique composition of subunits, which allows for tissue-specific regulation of lactate levels during anaerobic respiration. This specificity is vital for the proper functioning of different organs, especially during times of stress or exercise. In clinical practice, measuring the levels of specific isoenzymes (同工酶) can provide valuable diagnostic information. For example, an increase in the LDH-1 isoenzyme (同工酶) in the bloodstream is often associated with myocardial infarction, as it is predominantly found in cardiac tissue. Therefore, the presence of this particular isoenzyme (同工酶) can help physicians determine the extent of heart damage and guide treatment decisions. Moreover, isoenzymes (同工酶) can exhibit different affinities for substrates and varying responses to inhibitors. This variability means that they can be selectively targeted in drug development, leading to more effective therapies with fewer side effects. For instance, certain anticancer drugs may target specific isoenzymes (同工酶) that are overexpressed in tumor cells, thereby sparing normal cells and reducing toxicity. Additionally, studying isoenzymes (同工酶) can enhance our understanding of evolutionary biology. The presence of multiple forms of an enzyme suggests adaptive advantages in different environmental conditions or metabolic demands. For example, organisms living in extreme environments may have isoenzymes (同工酶) that maintain activity at high temperatures or varying pH levels. This adaptability is a testament to the evolutionary pressures that shape enzyme function and diversity. In summary, isoenzymes (同工酶) are essential components of biological systems, providing insight into metabolic regulation, disease diagnosis, and therapeutic strategies. Their study not only enriches our understanding of enzymatic functions but also highlights the intricate relationships between structure and function in biochemistry. As research continues to uncover the complexities of isoenzymes (同工酶), we can anticipate advancements in personalized medicine and biotechnology, ultimately improving health outcomes and enhancing our comprehension of life processes.

同工酶，也被称为同种型或酶变体，是催化相同化学反应但在结构和动力学特性上有所不同的酶的不同形式。这些变异可以由于遗传差异、翻译后修饰或mRNA的选择性剪接而产生。理解同工酶在各个领域，特别是生物化学和医学中至关重要，因为它们在代谢途径中发挥重要作用，并可能影响药物的有效性。 例如，考虑乳酸脱氢酶（LDH）酶，它存在于几种同工酶中，这些同工酶在心脏、肝脏和肌肉等不同组织中表达。每种同工酶都有独特的亚基组成，这使得乳酸水平在厌氧呼吸期间能够进行组织特异性的调节。这种特异性对于不同器官的正常功能至关重要，尤其是在压力或运动期间。 在临床实践中，测量特定同工酶的水平可以提供宝贵的诊断信息。例如，血液中LDH-1同工酶的增加通常与心肌梗死相关，因为它主要存在于心脏组织中。因此，特定同工酶的存在可以帮助医生确定心脏损伤的程度并指导治疗决策。 此外，同工酶可能对底物表现出不同的亲和力和对抑制剂的不同反应。这种变异意味着它们可以在药物开发中被选择性靶向，从而导致更有效的疗法和更少的副作用。例如，某些抗癌药物可能会靶向在肿瘤细胞中过度表达的特定同工酶，从而保护正常细胞并减少毒性。 此外，研究同工酶可以增强我们对进化生物学的理解。多种酶形式的存在表明在不同环境条件或代谢需求下的适应优势。例如，生活在极端环境中的生物可能具有在高温或不同pH水平下保持活性的同工酶。这种适应性证明了塑造酶功能和多样性的进化压力。 总之，同工酶是生物系统的重要组成部分，提供了对代谢调节、疾病诊断和治疗策略的深入了解。它们的研究不仅丰富了我们对酶功能的理解，还突显了生物化学中结构与功能之间错综复杂的关系。随着研究继续揭示同工酶的复杂性，我们可以期待个性化医学和生物技术的进步，最终改善健康结果并增强我们对生命过程的理解。