isoforms

简明释义

英[ˈaɪ.səʊ.fɔːmz]美[ˈaɪ.soʊ.fɔrmz]

n. 亚型（isoform 的复数）

英英释义

单词用法

同义词

反义词

例句

1.Objective: to probe the expression and distribution of vascular endothelial growth factor (VEGF) and its isoforms in podocyte.

目的：探讨血管内皮细胞生长因子(VEGF)在足细胞内的分布及其所表达的VEGF亚型。

2.Methods: To set up the model of DI rats, the IP3R isoforms expressions of detrusor tissue in DI rats and ds rats were detected by RT-PCR technique.

方法：建立DI大鼠模型，应用逆转录-聚合酶链反应(RT - PCR)方法检测DI及逼尿肌稳定(DS)大鼠逼尿肌组织IP3R亚型变化。

3.In the classic hypothesis there are two isoforms of COX, COX-1 and COX-2, which are very similar in their structure but are very different in their expression pattern and function within organisms.

一般认为COX有两种同工酶：COX - 1和COX - 2，二者在结构上非常相似，但是它们在机体中的表达方式及功能却完全不同。

4.The highest correlation was present in blacks, followed by whites and Hispanics; was dependent on apo isoform size; and became progressively weaker with larger isoforms.

最高的关联出现在黑人中，接着是白人和西班牙人，依赖于载脂蛋白亚型的大小；随着亚型尺寸的增大而减弱。

5.These P63 isoforms perform their diverse biological functions in different tissues and different developmental phases.

这些P 63亚型蛋白，在不同的组织不同的发育阶段发挥不同的生物学功能。

6.Objective to explore the expression and effects of isoforms of macrophage colony-stimulating factor in human leukemic cell lines.

目的探讨异型巨噬细胞集落刺激因子在人白血病细胞系中的表达和性质。

7.The study focused on the different isoforms of the protein, which play distinct roles in cellular function.

这项研究集中在该蛋白质的不同同种型上，它们在细胞功能中发挥着不同的作用。

8.Researchers identified multiple isoforms of the enzyme that vary in activity and stability.

研究人员识别出多种活性和稳定性不同的酶同种型。

9.The presence of specific isoforms can indicate certain diseases in patients.

特定同种型的存在可以指示患者某些疾病。

10.The gene produces several isoforms through alternative splicing mechanisms.

该基因通过可变剪接机制产生几种同种型。

11.Different isoforms of a receptor can lead to varied responses to drugs.

不同的受体同种型可能导致对药物的不同反应。

作文

In the field of molecular biology, the term isoforms refers to different forms of the same protein that arise from the same gene. These variations can occur due to alternative splicing of mRNA, post-translational modifications, or genetic mutations. Understanding isoforms is crucial for researchers as they can have distinct biological functions and implications in various diseases. For instance, a single gene may produce multiple isoforms, each with unique properties that contribute to the complexity of cellular processes. The study of isoforms has gained significant attention in recent years, particularly in the context of cancer research. Different isoforms of oncogenes and tumor suppressor genes can influence cancer progression and response to treatment. For example, certain isoforms may promote cell proliferation, while others might inhibit growth, leading to different outcomes in tumor behavior. As a result, identifying and characterizing these isoforms can provide insights into the mechanisms of cancer and help in the development of targeted therapies. Moreover, isoforms are not limited to proteins alone; they can also be found in other biomolecules such as RNA. The existence of multiple isoforms allows for a greater diversity of functions within a cell, enabling it to adapt to changing environments and requirements. This versatility is particularly important in complex organisms where different tissues may require specific isoforms to perform their specialized functions. In addition to their biological significance, isoforms can also pose challenges in research and clinical settings. The presence of multiple isoforms can complicate the interpretation of experimental results, especially when using antibodies that may recognize more than one form of a protein. Therefore, it is essential for scientists to develop methods that can distinguish between different isoforms to accurately assess their roles in health and disease. In conclusion, isoforms play a vital role in the complexity of biological systems. Their diverse functions and implications in diseases highlight the importance of studying these variations at both the molecular and clinical levels. As research continues to uncover the intricacies of isoforms, we can expect to gain a deeper understanding of cellular mechanisms and improve therapeutic strategies for various conditions. The exploration of isoforms will undoubtedly remain a key area of focus in the quest to unravel the mysteries of life at the molecular level.

在分子生物学领域，术语isoforms指的是由同一个基因产生的不同形式的蛋白质。这些变异可能是由于mRNA的选择性剪接、翻译后修饰或基因突变所致。理解isoforms对研究人员至关重要，因为它们可能具有不同的生物功能，并在各种疾病中产生影响。例如，一个基因可能产生多个isoforms，每个isoforms具有独特的特性，这些特性有助于细胞过程的复杂性。 近年来，isoforms的研究引起了广泛关注，特别是在癌症研究的背景下。不同的癌基因和肿瘤抑制基因的isoforms可能影响癌症的进展和对治疗的反应。例如，某些isoforms可能促进细胞增殖，而其他可能抑制生长，导致肿瘤行为的不同结果。因此，识别和表征这些isoforms可以提供对癌症机制的深入了解，并帮助开发靶向治疗。 此外，isoforms不仅限于蛋白质；它们也可以在其他生物分子中找到，例如RNA。多个isoforms的存在允许细胞内功能的更大多样性，使其能够适应变化的环境和需求。这种多样性在复杂生物体中特别重要，因为不同的组织可能需要特定的isoforms来执行其专业功能。 除了生物学的重要性，isoforms在研究和临床环境中也可能带来挑战。多个isoforms的存在可能使实验结果的解释变得复杂，尤其是在使用可能识别多种蛋白质形式的抗体时。因此，科学家必须开发能够区分不同isoforms的方法，以准确评估它们在健康和疾病中的作用。 总之，isoforms在生物系统的复杂性中扮演着至关重要的角色。它们的多样功能及其在疾病中的影响突显了在分子和临床层面研究这些变异的重要性。随着研究不断揭示isoforms的复杂性，我们可以期待深入了解细胞机制，并改善各种疾病的治疗策略。探索isoforms无疑将继续成为揭开生命奥秘的关键领域。