isoform

简明释义

英[ˈaɪsəˌfɔrm]美[ˈaɪsəˌfɔrm]

n. 同种型；同等型

英英释义

单词用法

同义词

反义词

例句

1.The invention relates to recombinant polypeptides, in particular antibodies or antibody fragments, which are able to bind the ED-B isoform of fibronectin and block the function thereof.

本发明涉及重组多肽，特别是结合纤连蛋白的Ed-B-同种型并可阻断其功能的抗体或抗体片段。

2.The invention relates to recombinant polypeptides, in particular antibodies or antibody fragments, which are able to bind the ED-B isoform of fibronectin and block the function thereof.

本发明涉及重组多肽，特别是结合纤连蛋白的Ed-B-同种型并可阻断其功能的抗体或抗体片段。

3.Methods a dis continuous buffer system was used. CK MM isoform was separated by electrophoresis under the condition of constant current and low voltage, then fluorescence scanning.

方法采用不连续缓冲体系，在稳流低压条件下电泳分离CKMM亚型，荧光扫描。

4.The new GH isoform differed from classical growth hormone which had 2 GH receptor binding sites, and there was only one GH receptor binding site in the new GH isoform molecule.

与正常生长激素分子内有2个GH受体结合位点不同，该新的GH异形体分子内仅有一个生长激素受体的结合位点。

5.Aim: To detect effect of the different frequency of chronic electrical stimulation (CES) on myofibrillar isoform, myosin heavy chain (MHC) and metabolic enzyme activities.

目的：探讨不同频率慢性电刺激对膈肌肌纤维亚型、肌球蛋白重链(mhc)亚型和代谢酶活性的适应性变化的影响。

6.They found that the p53 gene makes not only the well-established p53 protein, but also an alternative "control switch" variation of the p53 protein - known as an isoform.

他们发现p53基因不仅产生大家熟知的p53蛋白质，同时还产生一种p53蛋白质变换“控制开关”的变种——对碘氧基苯甲醚。

7.The highest correlation was present in blacks, followed by whites and Hispanics; was dependent on apo isoform size; and became progressively weaker with larger isoforms.

最高的关联出现在黑人中，接着是白人和西班牙人，依赖于载脂蛋白亚型的大小；随着亚型尺寸的增大而减弱。

8.PCK2 (PEPCK2 or PEPCK-M) encodes an isoform of phosphoenolpyruvate carboxykinase (PEPCK) that is found in the mitochondria of renal and hepatic tissues (1).

(PEPCK2或PEPCK - M)编码一种磷酸烯醇丙酮酸羧激酶(PEPCK)亚型，在肾和肝组织线粒体中发现该亚型(1)。

9.Researchers discovered a new isoform that plays a crucial role in cancer progression.

研究人员发现了一种新的同种异构体，它在癌症进展中起着关键作用。

10.The isoform of the protein was found to be more active than its counterpart.

这种蛋白质的同种异构体被发现比其对应物更活跃。

11.Different tissues may express different isoforms of the same gene.

不同的组织可能会表达同一基因的不同同种异构体。

12.The study focused on the effects of a specific isoform on metabolic processes.

这项研究集中于特定同种异构体对代谢过程的影响。

13.Scientists are investigating how isoforms influence drug efficacy.

科学家们正在研究同种异构体如何影响药物的有效性。

作文

In the field of biology, the term isoform refers to different forms of the same protein that arise from a single gene. These variations can occur due to alternative splicing, post-translational modifications, or genetic mutations. Understanding isoforms is crucial for deciphering the complexities of cellular functions and disease mechanisms. For instance, certain isoforms of proteins might be expressed in specific tissues or at particular developmental stages, contributing to the diversity of biological functions. One prominent example of isoforms is the family of tropomyosin proteins, which play a significant role in muscle contraction and cytoskeletal dynamics. Different isoforms of tropomyosin are expressed in various types of muscle tissues, allowing for specialized functions that are essential for proper muscle performance. This specialization highlights the importance of isoforms in adapting protein functions to meet the needs of different cellular environments. Moreover, the study of isoforms has significant implications in the field of medicine. For example, cancer cells often express unique isoforms that differ from those in normal cells. These cancer-specific isoforms can serve as biomarkers for diagnosis and prognosis, as well as potential targets for therapeutic interventions. By focusing on these distinct isoforms, researchers can develop more effective treatments that specifically target cancerous cells while sparing healthy ones. In addition to cancer, isoforms also play a role in neurodegenerative diseases. For instance, in Alzheimer's disease, certain isoforms of amyloid precursor protein (APP) have been implicated in the formation of amyloid plaques, a hallmark of the disease. Understanding the different isoforms of APP and their respective roles in neuronal health and disease progression could lead to new strategies for intervention. The concept of isoforms extends beyond proteins to other biomolecules, including RNA. Alternative splicing of pre-mRNA can generate multiple isoforms of mRNA, which can then be translated into different protein variants. This process adds another layer of complexity to gene expression regulation, allowing cells to respond dynamically to environmental changes. In conclusion, the study of isoforms is fundamental to our understanding of biology and medicine. These variations in protein structure and function provide insight into the intricate workings of life at the molecular level. As research advances, the knowledge gained about isoforms will undoubtedly contribute to the development of innovative therapies and diagnostic tools, ultimately improving human health. Therefore, recognizing the significance of isoforms is essential for anyone engaged in the biological sciences, as it opens up avenues for exploration and discovery in both basic and applied research.

在生物学领域，术语isoform指的是由单个基因产生的同一蛋白质的不同形式。这些变体可能由于选择性剪接、翻译后修饰或基因突变而发生。理解isoforms对于解读细胞功能和疾病机制的复杂性至关重要。例如，某些蛋白质的isoforms可能在特定组织或特定发育阶段中表达，从而有助于生物功能的多样性。 一个显著的isoforms例子是肌动蛋白家族，这些蛋白在肌肉收缩和细胞骨架动态中发挥重要作用。不同的isoforms的肌动蛋白在各种类型的肌肉组织中表达，使其能够专门化以满足适当的肌肉性能需求。这种专业化突显了isoforms在适应蛋白质功能以满足不同细胞环境需求方面的重要性。 此外，isoforms的研究在医学领域具有重要意义。例如，癌细胞通常表达与正常细胞不同的独特isoforms。这些特异于癌症的isoforms可以作为诊断和预后标志物，以及潜在的治疗干预目标。通过关注这些独特的isoforms，研究人员可以开发出更有效的治疗方案，专门针对癌细胞，同时保护健康细胞。 除了癌症，isoforms还在神经退行性疾病中发挥作用。例如，在阿尔茨海默病中，某些isoforms的淀粉样前体蛋白（APP）被认为与淀粉样斑块的形成有关，这是该疾病的一个标志。理解APP的不同isoforms及其在神经元健康和疾病进展中的各自作用可能会导致新的干预策略。 isoforms的概念超越了蛋白质，还包括其他生物分子，包括RNA。前mRNA的选择性剪接可以生成多种isoforms的mRNA，然后可以翻译成不同的蛋白质变体。这个过程为基因表达调控增添了另一层复杂性，使细胞能够动态响应环境变化。 总之，isoforms的研究对我们理解生物学和医学至关重要。这些蛋白质结构和功能的变异提供了对生命在分子水平上复杂运作的洞察。随着研究的进展，对isoforms的知识无疑将有助于创新疗法和诊断工具的发展，最终改善人类健康。因此，认识到isoforms的重要性对于任何从事生物科学的人来说都是必要的，因为这为探索和发现开辟了新的途径。