lentivirus

简明释义

英[ˈlentɪˌvaɪərəs]美[ˈlentɪˌvaɪrəs]

n. 慢病毒属；慢病毒

英英释义

单词用法

同义词

反义词

例句

1.Lentivirus with GFP reporter can infect differentiated adipocytes. The infection efficiency was about 80%, and infected cells were in good conditions.

携带GF P报告基因的慢病毒可感染成熟脂肪细胞，感染率约为80%，且细胞被感染后状态良好。

2.This lays the foundation for the further research in gene therapy and can also help identify lentivirus titer.

构建成功的新型慢病毒载体为今后的基因治疗奠定了基础，也为慢病毒滴度的确定提供了一种新的可能。

3.Equine infectious anemia virus (EIAV) is a lentivirus. It related in sequence to the human immunodeficiency virus (HIV) and reacted with acquired immunodeficiency syndrome (AIDS) patient sera.

马传染性贫血病毒是反转录病毒科慢病毒属的成员之一，不仅与人免疫缺陷病毒具有序列同源性，而且与其血清具有交叉反应。

4.To investigate the effects of lentivirus-mediated transfection of GDNF on Parkinson's disease.

探讨慢病毒介导GDNF对帕金森病的治疗作用。

5.Objective To inject RF B cell transfected by lentivirus to arthritis rats, and to evaluate the curative effect.

目的慢病毒转染的RFB细胞静脉注入类风湿性关节炎大鼠，评价其治疗效果。

6.Equine infectious anemia virus (EIAV) is a lentivirus. It related in sequence to the human immunodeficiency virus (HIV) and reacted with acquired immunodeficiency syndrome (AIDS) patient sera.

马传染性贫血病毒是反转录病毒科慢病毒属的成员之一，不仅与人免疫缺陷病毒具有序列同源性，而且与其血清具有交叉反应。

7.They characterized this retrovirus as the first known human lentivirus based on its morphological, biochemical and immunological properties.

他们此病毒的特点是第一个已知的人类慢病毒根据其形态，生化和免疫学性质。

8.Objective To establish a culture system for human embryonic stem cell and label the hES cells with GFP by lentivirus.

目的稳定培养人胚胎干细胞，并通过慢病毒载体对其进行绿色荧光蛋白标记。

9.Neurons could survive in the culture for at least 8 weeks, during which the GFP was persistently expressed, indicating the lentivirus could efficiently and stably infect the neurons.

神经细胞至少能存活8周，在此期间GFP能持续表达，说明慢病毒能有效而稳定感染神经细胞。

10.Researchers are studying the effects of lentivirus on gene therapy techniques.

研究人员正在研究慢病毒对基因治疗技术的影响。

11.The lentivirus is often used as a vector for delivering genetic material into cells.

慢病毒通常用作将遗传物质传递到细胞中的载体。

12.In HIV research, scientists focus on the properties of lentivirus to develop new treatments.

在艾滋病研究中，科学家们关注慢病毒的特性，以开发新疗法。

13.A lentivirus can integrate its genetic material into the host genome, which poses challenges for treatment.

慢病毒可以将其遗传物质整合到宿主基因组中，这给治疗带来了挑战。

14.The safety of using lentivirus in clinical trials is a major concern for researchers.

在临床试验中使用慢病毒的安全性是研究人员非常关心的问题。

作文

The term lentivirus refers to a genus of viruses that are characterized by their long incubation periods and the ability to cause chronic infections. These viruses are part of the Retroviridae family and are known for their complex structure and unique replication cycle. One of the most well-known members of the lentivirus genus is the Human Immunodeficiency Virus (HIV), which is responsible for Acquired Immunodeficiency Syndrome (AIDS). Understanding lentivirus is crucial for both scientific research and public health initiatives, particularly in the fight against viral infections. Lentiviruses are unique because they can infect dividing as well as non-dividing cells, which sets them apart from other types of retroviruses. This ability allows lentivirus to integrate its genetic material into the host cell's DNA, leading to persistent infections that can last for years or even a lifetime. The replication process of lentivirus involves reverse transcription, where the viral RNA is converted into DNA, followed by integration into the host genome. This integration is a key factor in the challenges associated with treating infections caused by lentivirus, as it allows the virus to evade the immune system and antiviral therapies. The study of lentivirus has significant implications for the development of gene therapy techniques. Researchers have been exploring the potential of using lentivirus vectors to deliver therapeutic genes to target cells. This approach could potentially treat genetic disorders or certain types of cancer by correcting defective genes or introducing new ones that can help combat disease. The versatility of lentivirus as a delivery system makes it an attractive option for gene therapy, although safety concerns regarding insertional mutagenesis and immune responses must be carefully addressed. In addition to HIV, other notable lentivirus species include the Simian Immunodeficiency Virus (SIV), which affects primates, and the Feline Immunodeficiency Virus (FIV), which impacts cats. Each of these viruses shares similar characteristics with HIV, including their mode of transmission and the chronic nature of the diseases they cause. The study of these viruses not only enhances our understanding of lentivirus biology but also provides insights into the evolution of viral pathogens and their interactions with host organisms. Preventing the spread of lentivirus infections, particularly HIV, requires comprehensive public health strategies. Education about safe sex practices, needle exchange programs, and the availability of antiretroviral therapy have proven effective in reducing transmission rates. Vaccination efforts are also underway, as scientists aim to develop an effective vaccine against lentivirus infections. However, challenges remain due to the virus's ability to mutate rapidly, which complicates vaccine development and efficacy. In conclusion, the lentivirus genus represents a critical area of study within virology and infectious disease research. Its unique characteristics and implications for human health necessitate ongoing investigation and innovation in treatment and prevention strategies. As we continue to learn more about lentivirus and its impact on various populations, we can better equip ourselves to combat these persistent viral infections and improve public health outcomes worldwide.

术语lentivirus指的是一类病毒，其特征是潜伏期长并且能够引起慢性感染。这些病毒属于逆转录病毒科，以其复杂的结构和独特的复制周期而闻名。最著名的lentivirus成员之一是人类免疫缺陷病毒（HIV），它是导致获得性免疫缺陷综合症（AIDS）的病因。理解lentivirus对科学研究和公共卫生倡议至关重要，尤其是在抗击病毒感染的斗争中。 lentivirus的独特之处在于它们可以感染分裂细胞和非分裂细胞，这使它们与其他类型的逆转录病毒不同。这种能力使得lentivirus能够将其遗传物质整合到宿主细胞的DNA中，从而导致持久的感染，可以持续多年甚至终生。lentivirus的复制过程涉及逆转录，即病毒RNA转化为DNA，然后整合到宿主基因组中。这种整合是治疗由lentivirus引起的感染时面临的挑战的关键因素，因为它使病毒能够逃避免疫系统和抗病毒治疗。 对lentivirus的研究对基因治疗技术的发展具有重要意义。研究人员一直在探索利用lentivirus载体将治疗基因传递到目标细胞的潜力。这种方法可能通过纠正缺陷基因或引入新的基因来帮助对抗疾病，从而治疗遗传疾病或某些类型的癌症。由于lentivirus作为递送系统的多功能性，使其成为基因治疗的有吸引力的选择，尽管关于插入突变和免疫反应的安全性问题必须得到认真解决。 除了HIV，其他显著的lentivirus物种包括影响灵长类动物的猿类免疫缺陷病毒（SIV）和影响猫的猫免疫缺陷病毒（FIV）。这些病毒中的每一种都与HIV共享类似的特征，包括传播方式和它们引起的疾病的慢性特性。对这些病毒的研究不仅增强了我们对lentivirus生物学的理解，还提供了对病毒病原体及其与宿主生物相互作用的进化洞察。 预防lentivirus感染的传播，特别是HIV，需要全面的公共卫生策略。有关安全性行为的教育、针具交换计划和抗逆转录病毒治疗的可用性已被证明有效地减少了传播率。疫苗接种工作也在进行中，科学家们旨在开发针对lentivirus感染的有效疫苗。然而，由于病毒的快速变异能力，疫苗的开发和有效性仍然面临挑战。 总之，lentivirus属在病毒学和传染病研究中代表了一个关键的研究领域。其独特的特征及其对人类健康的影响需要持续的调查和治疗、预防策略的创新。随着我们对lentivirus及其对各个群体影响的了解不断加深，我们可以更好地装备自己，以对抗这些顽固的病毒感染，并改善全球公共健康结果。