methylation

简明释义

英[ˌmɛθɪˈleɪʃən]美[ˌmɛθɪˈleɪʃən]

n. [有化] 甲基化，甲基化作用

英英释义

单词用法

同义词

反义词

例句

1.Methylation of chromatin causes it to condense.

染色质甲基化后会出现凝缩。

2.The presumption is that the pattern of methylation, by controlling which proteins are manufactured, helps determine what type of cell is produced.

推论是甲基化模式通过控制蛋白质的合成从而决定形成什么样的细胞.

3.When a methyl group attaches to a specific spot on a gene - a process called DNA methylation.

甲基附加到基因上某个特殊点的过程，称为DNA甲基化。

4.Moreover, the methylation patterns were clustered together in large swaths of DNA, suggesting an epigenetic pattern linked to humans’ early environments.

而且，甲基化的模式在DNA长链中被聚集到一起，显示了与早期环境相关的后天模式。

5.Here, we review the role of epigenetics in aging and longevity with a focus on DNA methylation.

这里，我们回顾了表观遗传学在衰老和长寿中的作用，集中在DNA甲基化。

6.Discussing the relations of DNA methylation and gene transcriptional silencing takes on important significances for the study of many human diseases.

探讨DNA甲基化与基因转录抑制之间的关系，对许多人类疾病的研究具有重要意义。

7.The process of methylation can influence gene expression.

这个过程中的甲基化可以影响基因表达。

8.Scientists are studying the role of methylation in cancer development.

科学家们正在研究甲基化在癌症发展中的作用。

9.DNA methylation patterns can be inherited from parents.

DNA的甲基化模式可以从父母那里遗传。

10.Changes in methylation can lead to various diseases.

在甲基化方面的变化可能导致各种疾病。

11.Environmental factors can affect DNA methylation levels.

环境因素可以影响DNA的甲基化水平。

作文

Methylation is a crucial biochemical process that plays a significant role in gene regulation and expression. In simple terms, methylation">methylation refers to the addition of a methyl group, which consists of one carbon atom and three hydrogen atoms (–CH3), to a molecule, often DNA. This process can have profound effects on how genes are turned on or off, thereby influencing various biological functions and traits. Understanding methylation">methylation is essential for researchers and medical professionals alike, as it opens up new avenues for understanding diseases and developing potential therapies. One of the most fascinating aspects of methylation">methylation is its role in epigenetics. Epigenetics is the study of changes in organisms caused by modification of gene expression rather than alteration of the genetic code itself. Methylation can lead to stable changes in gene expression without changing the underlying DNA sequence. For instance, when a methyl group is added to a specific site on a gene, it can prevent the gene from being expressed, effectively silencing it. This silencing can be temporary or permanent, depending on the context and environment. The implications of methylation">methylation are vast. In human health, abnormal patterns of methylation have been linked to various diseases, including cancer. In many cancers, certain tumor suppressor genes are found to be hypermethylated, meaning they are excessively methylated and thus silenced. This silencing allows cancer cells to grow uncontrollably. Conversely, some oncogenes, which promote cell growth, may be hypomethylated, leading to their overexpression. Therefore, studying the patterns of methylation">methylation in cancer cells can provide insights into the mechanisms of tumor development and progression. Moreover, methylation">methylation is also influenced by environmental factors such as diet, stress, and exposure to toxins. For example, certain nutrients like folate and B vitamins are known to play a role in the methylation cycle, influencing how efficiently cells can add or remove methyl groups. This relationship between diet and methylation">methylation highlights the importance of nutrition in maintaining gene function and preventing disease. Additionally, studies have shown that lifestyle factors, such as smoking and physical activity, can affect methylation patterns, further emphasizing the interplay between our environment and our genetic expression. In conclusion, methylation">methylation is a vital process that not only regulates gene expression but also has significant implications for health and disease. As research continues to uncover the complexities of this process, it becomes increasingly clear that understanding methylation">methylation could lead to innovative approaches in medicine, particularly in the fields of cancer treatment and prevention. By exploring the intricate relationships between methylation">methylation, genetics, and environmental factors, we can gain a deeper insight into the biological mechanisms that govern our health and well-being.

甲基化是一个关键的生化过程，在基因调控和表达中发挥着重要作用。简单来说，methylation">methylation指的是将一个甲基团（由一个碳原子和三个氢原子组成 –CH3）添加到一个分子上，通常是DNA。这个过程可以对基因的开启或关闭产生深远的影响，从而影响各种生物功能和特征。理解methylation">methylation对研究人员和医疗专业人员来说至关重要，因为它为理解疾病和开发潜在疗法开辟了新的途径。 methylation">methylation最迷人的一个方面是它在表观遗传学中的作用。表观遗传学是研究通过改变基因表达而非改变遗传密码本身引起的生物体变化的学科。甲基化可以导致基因表达的稳定变化，而不改变基础的DNA序列。例如，当一个甲基团添加到某个基因的特定位置时，它可以阻止该基因的表达，有效地使其沉默。这种沉默可以是暂时的，也可以是永久的，具体取决于上下文和环境。 methylation">methylation的影响是广泛的。在人类健康方面，异常的甲基化模式与多种疾病有关，包括癌症。在许多癌症中，某些肿瘤抑制基因被发现过度甲基化，这意味着它们被过度甲基化并因此被沉默。这种沉默使癌细胞失去控制地生长。相反，一些癌基因可能是低甲基化的，导致它们的过度表达。因此，研究癌细胞中的methylation">methylation模式可以提供肿瘤发展和进展机制的见解。 此外，methylation">methylation也受到饮食、压力和毒素暴露等环境因素的影响。例如，某些营养素如叶酸和B族维生素已知在甲基化循环中发挥作用，影响细胞添加或去除甲基团的效率。这种饮食与methylation">methylation之间的关系强调了营养在维持基因功能和预防疾病中的重要性。此外，研究表明，生活方式因素如吸烟和身体活动也会影响甲基化模式，进一步强调了我们环境与基因表达之间的相互作用。 总之，methylation">methylation是一个重要的过程，不仅调节基因表达，而且对健康和疾病具有重要影响。随着研究不断揭示这一过程的复杂性，越来越明显的是，理解methylation">methylation可能导致医学上创新方法的出现，特别是在癌症治疗和预防领域。通过探索methylation">methylation、遗传学与环境因素之间的复杂关系，我们可以更深入地了解支配我们健康和福祉的生物机制。