neurofibrillary

简明释义

英[ˌnjʊərəˈfaɪbrəˌlɛri]美[ˌnʊroʊˈfaɪbrəˌlɛri]

神经元纤维

英英释义

单词用法

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例句

1.Neuritic plaques(NPs)and neurofibrillary tangles(NFTs)are the two most characteristic pathologic hallmarks of AD.

神经炎性斑块和神经纤维缠结是AD主要的病理学特征。

2.Neuritic plaques(NPs)and neurofibrillary tangles(NFTs)are the two most characteristic pathologic hallmarks of AD.

神经炎性斑块和神经纤维缠结是AD主要的病理学特征。

3.This disorder leaves behind two very important clues: amyloid plaques and neurofibrillary tangles.

这种疾病留给我们两个重要线索：淀粉质色斑和神经元纤维的混乱。

4.The CAA was often accompanied with the senile plaques and neurofibrillary tangles.

CAA往往同时伴有老年斑和神经原纤维缠结。

5.The presence of neurofibrillary 神经纤维性 tangles is a hallmark of Alzheimer's disease.

神经纤维性缠结的存在是阿尔茨海默病的一个标志。

6.Researchers are studying the role of neurofibrillary 神经纤维性 pathology in various neurodegenerative disorders.

研究人员正在研究神经纤维性病理在各种神经退行性疾病中的作用。

7.Autopsies often reveal neurofibrillary 神经纤维性 tangles in patients who suffered from dementia.

尸检常常揭示出在患有痴呆症的患者中存在神经纤维性缠结。

8.The accumulation of neurofibrillary 神经纤维性 tangles can disrupt normal brain function.

神经纤维性缠结的积累会干扰正常的大脑功能。

9.Studies indicate a correlation between neurofibrillary 神经纤维性 tangles and cognitive decline.

研究表明，神经纤维性缠结与认知衰退之间存在相关性。

作文

Neurofibrillary tangles are a hallmark of several neurodegenerative diseases, most notably Alzheimer's disease. These pathological structures are primarily composed of hyperphosphorylated tau protein, which becomes misfolded and aggregates within neurons. The presence of neurofibrillary (神经纤维性) tangles is significant because they disrupt the normal functioning of neurons, leading to cell death and cognitive decline. Understanding the formation and implications of these tangles is crucial for developing therapeutic strategies aimed at combating Alzheimer's and other related disorders. The process begins when tau protein, which normally stabilizes microtubules in neuronal cells, undergoes abnormal phosphorylation. This modification causes tau to detach from microtubules and aggregate into paired helical filaments, eventually forming neurofibrillary (神经纤维性) tangles. As these tangles accumulate, they interfere with intracellular transport mechanisms, impairing the delivery of essential nutrients and signals throughout the neuron. Research has shown that the development of neurofibrillary (神经纤维性) tangles correlates strongly with the severity of cognitive impairment in Alzheimer's patients. The more extensive the presence of these tangles, the greater the degree of memory loss and cognitive dysfunction observed. This relationship underscores the importance of early detection and intervention strategies aimed at reducing tau phosphorylation or promoting its clearance from the brain. In addition to their role in Alzheimer’s disease, neurofibrillary (神经纤维性) tangles are also found in other forms of dementia, such as frontotemporal dementia and certain types of Parkinson's disease. This suggests that the mechanisms underlying tau pathology may be common across various neurodegenerative conditions. As researchers continue to explore the biology of tau and its aggregation, potential therapeutic targets are emerging, including tau kinase inhibitors and immunotherapy approaches designed to enhance the clearance of neurofibrillary (神经纤维性) tangles from the brain. Moreover, the study of neurofibrillary (神经纤维性) tangles extends beyond understanding these diseases; it also provides insight into the aging process itself. As we age, the regulation of tau phosphorylation appears to become less effective, increasing the likelihood of tangle formation. This raises important questions about how lifestyle factors, such as diet and exercise, might influence tau pathology and cognitive health in older adults. In conclusion, neurofibrillary (神经纤维性) tangles represent a critical area of research in the field of neurodegenerative diseases. Their formation is intricately linked to the pathophysiology of Alzheimer's disease and other dementias, making them a focal point for the development of new therapeutic interventions. By deepening our understanding of these structures, we can hope to uncover novel strategies to prevent or mitigate the devastating effects of neurodegeneration on individuals and society as a whole.