osteoclastic

简明释义

英[ˌɒstɪəʊˈklæstɪk]美[ˌɑstəˈklæstɪk]

折骨的

破坏骨的

英英释义

单词用法

同义词

反义词

例句

1.The effect of ICD was stronger than that of APD. Conclusion ICD directly suppresses osteoclastic bone resorption and may be effective in osteoporosis.

结论ICD具有较强的直接抑制破骨细胞性骨吸收的作用，对骨质疏松症可能有一定的治疗作用。

2.The effect of ICD was stronger than that of APD. Conclusion ICD directly suppresses osteoclastic bone resorption and may be effective in osteoporosis.

结论ICD具有较强的直接抑制破骨细胞性骨吸收的作用，对骨质疏松症可能有一定的治疗作用。

3.Conclusion: Nylestriol can inhibit expression of IL 6 mRNA, reduce osteoclastic bone resorption and decrease loss of bone mass.

结论：尼尔雌醇可以抑制IL6基因表达，从而抑制破骨细胞骨吸收，减少骨量丢失。

4.It is suggested that APD could directly suppress osteoclastic bone resorption and might be effective in osteoporosis.

提示APD具有较强的直接抑制破骨细胞性骨吸收的作用，对骨质疏松症可能有一定的疗效。

5.We compared th effect of interleukin-1 (IL1) alone or with osteoblasts on osteoclastic bone re-sorption.

建立了成骨细胞和破骨细胞共同培养体系，探讨了白细胞介素-1（IL1）促进骨吸收的作用机理。

6.Objective To study the effects of domestic incadronate(ICD) on osteoclastic bone resorbing lacunae.

目的研究国产因卡磷酸钠（ICD）对破骨细胞性骨吸收的作用。

7.Control defects showed no osteoclastic activity with little to no bony healing.

对照缺损组未出现任何的破骨活性，也没有骨修复现象。

8.The study focused on the role of osteoclastic 破骨细胞的 activity in bone resorption.

这项研究集中于破骨细胞的活动在骨吸收中的作用。

9.In patients with osteoporosis, osteoclastic 破骨细胞的 activity is often increased.

在患有骨质疏松症的患者中，破骨细胞的活动通常会增加。

10.The balance between osteoclastic 破骨细胞的 and osteoblastic activity is crucial for bone health.

维持破骨细胞的活动与成骨细胞活动之间的平衡对骨骼健康至关重要。

11.Research has shown that certain hormones can inhibit osteoclastic 破骨细胞的 function.

研究表明，某些激素可以抑制破骨细胞的功能。

12.The drug was designed to target osteoclastic 破骨细胞的 activity to prevent bone loss.

该药物旨在针对破骨细胞的活动以防止骨质流失。

作文

Bone health is a crucial aspect of overall well-being, and understanding the cellular processes involved in bone remodeling is essential for maintaining strong bones. One key player in this process is the osteoclast, a type of cell responsible for bone resorption. The term osteoclastic refers to the activities and characteristics of these cells. 破骨细胞的功能是通过分解和吸收骨组织来调节骨密度，确保骨骼系统的健康。 Osteoclasts originate from monocyte/macrophage lineage and are multinucleated giant cells that play a vital role in the bone remodeling cycle. This cycle involves the continuous process of bone formation by osteoblasts and bone resorption by osteoclasts. The balance between these two cell types is essential; if osteoclast activity is too high relative to osteoblast activity, it can lead to conditions such as osteoporosis, where bones become weak and brittle. Conversely, insufficient osteoclastic activity can result in excessive bone density, leading to other complications. The regulation of osteoclastic activity is complex and involves various signaling pathways and hormones. For instance, parathyroid hormone (PTH) stimulates osteoclast formation and activity, while calcitonin acts to inhibit it. Additionally, RANKL (Receptor Activator of Nuclear factor Kappa-Β Ligand) is a crucial factor that promotes the differentiation of osteoclast precursors into mature osteoclasts. Understanding these mechanisms is vital for developing treatments for bone diseases that involve osteoclastic dysfunction. Research has shown that factors such as age, diet, and physical activity can significantly influence osteoclast function. For example, as people age, the balance between osteoclasts and osteoblasts tends to shift, often resulting in increased osteoclastic activity. This is why maintaining a healthy lifestyle, including regular weight-bearing exercises and adequate calcium and vitamin D intake, is critical for preserving bone health as we age. In recent years, scientists have been exploring targeted therapies that can modulate osteoclastic activity to treat bone disorders. Bisphosphonates and denosumab are examples of medications that inhibit osteoclast function, thereby reducing bone resorption and helping to prevent fractures in individuals with osteoporosis. However, these treatments must be carefully managed, as overly suppressing osteoclastic activity can lead to adverse effects, such as atypical femur fractures or osteonecrosis of the jaw. In conclusion, the study of osteoclastic activity is vital for understanding bone health and disease. As researchers continue to uncover the intricate details of how these cells function and are regulated, new therapeutic strategies will emerge, offering hope for those affected by bone-related conditions. By promoting awareness of the importance of balanced bone remodeling and the role of osteoclasts, we can encourage healthier lifestyles and better management of bone health throughout life.

骨骼健康是整体健康的重要方面，理解骨重塑中涉及的细胞过程对于维持强健的骨骼至关重要。一个关键角色是破骨细胞，这是一种负责骨吸收的细胞。术语osteoclastic指的是这些细胞的活动和特征。破骨细胞的功能是通过分解和吸收骨组织来调节骨密度，确保骨骼系统的健康。 破骨细胞起源于单核细胞/巨噬细胞谱系，是多核巨型细胞，在骨重塑周期中发挥着重要作用。这个周期涉及到破骨细胞的骨形成和骨吸收的持续过程。这两种细胞类型之间的平衡至关重要；如果破骨细胞的活动相对于成骨细胞的活动过高，就会导致如骨质疏松症等疾病，骨骼变得脆弱和易碎。相反，破骨细胞活动不足可能导致骨密度过高，从而引发其他并发症。 osteoclastic活动的调节是复杂的，涉及多种信号通路和激素。例如，甲状旁腺激素（PTH）刺激破骨细胞的形成和活动，而降钙素则起到抑制作用。此外，RANKL（核因子κB配体的受体激活因子）是促进破骨细胞前体分化为成熟破骨细胞的关键因素。理解这些机制对于开发针对破骨细胞功能障碍的骨病治疗至关重要。 研究表明，年龄、饮食和身体活动等因素可以显著影响破骨细胞功能。例如，随着人们的年龄增长，破骨细胞和成骨细胞之间的平衡往往会发生变化，通常导致破骨细胞活动增加。这就是为什么维持健康的生活方式，包括定期进行负重锻炼以及摄入足够的钙和维生素D，对于在老年时保持骨骼健康至关重要。 近年来，科学家们一直在探索能够调节osteoclastic活动的靶向疗法，以治疗骨骼疾病。双膦酸盐和地诺单抗是抑制破骨细胞功能的药物示例，从而减少骨吸收，帮助预防骨质疏松症患者的骨折。然而，这些治疗必须谨慎管理，因为过度抑制破骨细胞活动可能导致不良反应，例如非典型股骨骨折或下颌骨坏死。 总之，研究osteoclastic活动对于理解骨骼健康和疾病至关重要。随着研究人员继续揭示这些细胞如何运作和被调节的复杂细节，新的治疗策略将会出现，为那些受到骨相关疾病影响的人们带来希望。通过提高对骨重塑平衡及破骨细胞角色重要性的认识，我们可以鼓励更健康的生活方式，并更好地管理整个生命中的骨骼健康。