osteoclasts

简明释义

英[ˈɒstɪəʊklæsts]美[ˈɑstɪˌklæsts]

n. [组织]破骨细胞（osteoclast 的复数形式）

英英释义

单词用法

同义词

反义词

例句

1.The morphology of multinuclear giant cells (MGC) and osteoclasts (Oc) in rabbit's radius callus had been observed by light microscopy and transmission electron microscopy.

本文通过光镜与透射电镜对家兔桡骨标准分析模型骨痂内多核巨细胞与破骨细胞形态进行了观察。

2.Objective To investigate the effects of serum from kidneytonifing traditional Chinese drugfed rats on the osteoclasts in the osteoblastosteoclast coculture system.

目的探讨喂饲补肾中药大鼠血清在成骨细胞破骨细胞培养体系中对破骨细胞骨吸收功能的影响。

3.Results Osteoblasts are full fusiform, ALP stain positive cells, while osteoclasts are multinuclear and TRAP stain positive, with the ability of forming bone lacuna;

结果成骨细胞呈饱满的梭形，ALP染色阳性；破骨细胞呈多核，TRAP染色阳性，可以吸收骨质形成骨陷窝。

4.What happens is that you take the medicine, the osteoclasts absorb it, and it poisons the osteoclast cells by cutting off their blood supply.

事情是这样的，当你吃了药，破骨细胞会吸收它“双磷酸盐”，然后“双磷酸盐”会切断破骨细胞的血液供应。

5.RUNX2 is also associated with the formation of osteoclasts and extracellular matrix.

另外，RUNX2与破骨细胞和细胞外基质的形成也有关。

6.Result: the prevention group could effectively reduce the number of osteoclasts and the rate of empty lacunae femoral head.

结果：预防组能有效的降低破骨细胞数量及股骨头空骨陷窝率。

7.During bone remodeling, osteoclasts play a crucial role in breaking down old bone tissue.

在骨重塑过程中，破骨细胞 在分解旧骨组织中发挥着关键作用。

8.Researchers found that the activity of osteoclasts increases in patients with osteoporosis.

研究人员发现，患有骨质疏松症的患者中，破骨细胞 的活性增加。

9.The balance between osteoclasts and osteoblasts is essential for maintaining healthy bones.

维持健康骨骼所需的平衡在于 破骨细胞 和成骨细胞之间。

10.Certain medications can inhibit the function of osteoclasts to help prevent bone loss.

某些药物可以抑制 破骨细胞 的功能，以帮助防止骨质流失。

11.Increased numbers of osteoclasts have been observed in inflammatory bone diseases.

在炎症性骨病中观察到 破骨细胞 数量增加。

作文

The human body is a complex structure composed of various types of cells that work together to maintain health and homeostasis. Among these cells, one important type is known as osteoclasts, which play a crucial role in bone metabolism. Osteoclasts are specialized cells responsible for the resorption of bone tissue, a process that is essential for maintaining the balance between bone formation and bone resorption. This balance is vital for overall skeletal health and function.

Bone is a dynamic tissue that is constantly being remodeled throughout a person's life. This remodeling process involves the coordinated actions of two main types of cells: osteoblasts and osteoclasts. While osteoblasts are responsible for bone formation, osteoclasts break down old or damaged bone. This process ensures that the skeleton remains strong and can adapt to the stresses placed upon it.

In healthy individuals, the activity of osteoclasts is tightly regulated. Hormones such as parathyroid hormone (PTH) and calcitonin play significant roles in modulating their activity. When the body needs to release calcium into the bloodstream, PTH stimulates osteoclasts to increase bone resorption, thus releasing calcium stored in the bones. Conversely, when calcium levels are adequate, calcitonin inhibits osteoclasts to prevent excessive bone loss.

However, an imbalance in the activity of osteoclasts can lead to various bone disorders. For example, if osteoclasts are overactive, this can result in conditions such as osteoporosis, where bones become weak and brittle due to excessive bone loss. On the other hand, if osteoclasts are underactive, it can lead to conditions like osteopetrosis, characterized by overly dense but fragile bones.

The study of osteoclasts is critical in understanding and treating these bone-related diseases. Researchers are exploring various therapeutic approaches to regulate osteoclasts activity. For instance, medications that inhibit osteoclasts have been developed for the treatment of osteoporosis, helping to reduce the risk of fractures in at-risk populations.

In conclusion, osteoclasts are essential cells in the human body that contribute significantly to bone health through their role in bone resorption. Understanding the functions and regulation of osteoclasts is vital for maintaining skeletal integrity and combating bone diseases. As research continues to advance, it holds promise for developing new treatments that target osteoclasts and improve the quality of life for those affected by bone disorders.

人体是一个复杂的结构，由各种类型的细胞组成，这些细胞共同工作以维持健康和稳态。在这些细胞中，有一种重要的细胞被称为破骨细胞，它们在骨骼代谢中发挥着至关重要的作用。破骨细胞是负责骨组织吸收的特化细胞，这一过程对于维持骨形成与骨吸收之间的平衡至关重要。这种平衡对整体骨骼健康和功能至关重要。

骨骼是一种动态组织，贯穿一个人的一生不断重塑。这一重塑过程涉及两种主要类型细胞的协调作用：成骨细胞和破骨细胞。成骨细胞负责骨形成，而破骨细胞则分解旧的或受损的骨组织。这个过程确保骨骼保持强壮，并能够适应施加在其上的压力。

在健康个体中，破骨细胞的活动受到严格调节。激素如甲状旁腺激素（PTH）和降钙素在调节其活动中发挥重要作用。当身体需要将钙释放到血液中时，PTH刺激破骨细胞增加骨吸收，从而释放存储在骨骼中的钙。相反，当钙水平足够时，降钙素抑制破骨细胞以防止过度骨质流失。

然而，破骨细胞活动的不平衡可能导致各种骨骼疾病。例如，如果破骨细胞过于活跃，可能会导致如骨质疏松症等疾病，骨骼因过度流失而变得脆弱和易碎。另一方面，如果破骨细胞活性不足，可能会导致如骨质增生症的疾病，其特征是骨骼过于密集但脆弱。

对破骨细胞的研究对于理解和治疗这些骨相关疾病至关重要。研究人员正在探索各种治疗方法来调节破骨细胞的活动。例如，已经开发出抑制破骨细胞的药物用于治疗骨质疏松症，帮助减少高风险人群的骨折风险。

总之，破骨细胞是人体内必不可少的细胞，通过其在骨吸收中的作用显著影响骨骼健康。了解破骨细胞的功能和调节对于维持骨骼完整性和对抗骨骼疾病至关重要。随着研究的不断推进，它为开发针对破骨细胞的新治疗方法并改善受骨病影响者的生活质量带来了希望。