osteoclast

简明释义

英[ˈɒstiəʊˌklæst]美[ˈɑstɪəklæst]

n. [组织] 破骨细胞；[外科] 折骨器

英英释义

单词用法

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反义词

例句

1.The inhibition of the differentiation and maturity of osteoclast will inhibit bone resorption.

抑制破骨细胞的分化成熟就能有效控制骨的吸收。

2.Determine the effect of BBC-containing serum on absorption of lacuna formed by oc in osteoblast and osteoclast co-culture system by toluidine blue staining.

运用甲苯胺蓝染色法观察含药血清对成骨细胞-破骨细胞共育体系中OC形成骨吸收陷窝的影响。

3.CONCLUSION: the inducing culture of osteoclast-like cells are gradually progressed, and the mechanisms have also been initially revealed.

结论：破骨样细胞的诱导培养已逐渐成熟，其具体机制得到初步揭示。

4.Summary of Background Data. Osteopetrosis is characterized by osteoclast dysfunction, impaired bone resorption, and poor bone remodeling.

石骨症的特征是破骨细胞功能出现障碍，使骨吸收减慢，导致骨再建缺陷。

5.Purpose To study the clinicopathological features of renal tumors with osteoclast-like giant cells (RT-OGC).

目的探讨伴破骨细胞样巨细胞肾肿瘤(RT OGC)的临床病理特点。

6.Object: the study is to find a feasibility method of obtaining human osteoclast-like cells for the purpose of further research.

目的：探讨可行的获取人破骨细胞样细胞以供进一步研究的方法。

7.What happens is that you take the medicine, the osteoclasts absorb it, and it poisons the osteoclast cells by cutting off their blood supply.

事情是这样的，当你吃了药，破骨细胞会吸收它“双磷酸盐”，然后“双磷酸盐”会切断破骨细胞的血液供应。

8.Objective to investigate the biological effects of platelet-derived growth factor (PDGF) -bb on the osteoclasts in the osteoblast-osteoclast co-culture system.

目的探讨血小板衍生生长因子(PDGF) -BB在成骨细胞-破骨细胞培养体系中对破骨细胞骨吸收功能的影响。

9.This review will focus on the physiology of the osteoclast .

本综述将着重讨论破骨细胞的生理。

10.The function of osteoclast is crucial for bone remodeling.

骨细胞的功能对骨重塑至关重要。

11.Researchers are studying how osteoclasts interact with osteoblasts during bone formation.

研究人员正在研究骨细胞在骨形成过程中如何与成骨细胞相互作用。

12.An increase in osteoclast activity can lead to osteoporosis.

骨细胞活动的增加可能导致骨质疏松症。

13.Certain medications aim to inhibit osteoclast function to treat bone diseases.

某些药物旨在抑制骨细胞的功能以治疗骨病。

14.In the lab, scientists can isolate osteoclasts from bone tissue samples.

在实验室中，科学家可以从骨组织样本中分离出骨细胞。

作文

The human body is a marvel of biological engineering, composed of various cells that work together to maintain homeostasis and support life. Among these cells, one of the most fascinating types is the osteoclast, which plays a crucial role in bone metabolism. 骨细胞 are specialized cells responsible for the resorption of bone tissue, a process that is essential for the maintenance, repair, and remodeling of bones throughout a person's life. To understand the importance of osteoclasts, it is necessary to explore their function within the skeletal system. Bones are not static structures; they are constantly undergoing a cycle of formation and resorption. This dynamic process is regulated by a balance between osteoclasts and another type of cell called osteoblasts, which are responsible for bone formation. When the body requires calcium or when there is damage to the bone, osteoclasts become active, breaking down the mineralized matrix of the bone and releasing stored calcium into the bloodstream. The activity of osteoclasts is tightly regulated by hormones and signaling molecules. For instance, parathyroid hormone (PTH) stimulates osteoclast activity to increase calcium levels in the blood, while calcitonin inhibits their function to lower blood calcium levels. This intricate hormonal control ensures that the body maintains optimal calcium levels, which are vital for numerous physiological processes, including muscle contraction, nerve transmission, and blood clotting. In addition to their role in calcium homeostasis, osteoclasts are also involved in the repair of bone fractures. When a bone is fractured, the body initiates a healing process that involves inflammation, the formation of new tissue, and ultimately, the remodeling of the bone. Osteoclasts help to remove damaged bone tissue, allowing osteoblasts to lay down new bone material. This collaboration between osteoclasts and osteoblasts is essential for effective healing and recovery. However, an imbalance in the activity of osteoclasts and osteoblasts can lead to various bone disorders. For example, excessive osteoclast activity can result in conditions such as osteoporosis, where bones become weak and brittle due to increased resorption. Conversely, insufficient osteoclast activity can lead to osteopetrosis, a condition characterized by abnormally dense bones that can become fragile and prone to fracture. Research into osteoclasts has significant implications for the treatment of bone-related diseases. Understanding the mechanisms that regulate osteoclast activity can lead to the development of targeted therapies for osteoporosis and other conditions. For instance, medications that inhibit osteoclast function, such as bisphosphonates, are commonly prescribed to reduce bone loss in individuals with osteoporosis. In conclusion, osteoclasts are vital components of our skeletal system, playing a key role in bone resorption and remodeling. Their activity is essential for maintaining calcium homeostasis and facilitating bone repair. As research continues to uncover the complexities of osteoclast function, we gain valuable insights into potential therapeutic approaches for managing bone health and treating related disorders. Understanding the delicate balance between osteoclasts and osteoblasts is crucial for promoting a healthy skeletal system and ensuring overall well-being.

人体是生物工程的奇迹，由各种细胞组成，这些细胞共同工作以维持内稳态并支持生命。在这些细胞中，最引人入胜的一种是骨细胞，它在骨代谢中发挥着至关重要的作用。骨细胞是专门负责骨组织吸收的细胞，这一过程对维持、修复和重塑整个生命过程中的骨骼至关重要。 要理解骨细胞的重要性，有必要探讨它们在骨骼系统中的功能。骨骼并不是静态结构；它们不断经历形成和吸收的循环。这个动态过程由骨细胞和另一种称为成骨细胞的细胞之间的平衡来调节，后者负责骨生成。当身体需要钙或骨骼受损时，骨细胞会变得活跃，分解骨骼的矿化基质，并将储存的钙释放到血液中。 骨细胞的活动受到激素和信号分子的严格调控。例如，甲状旁腺激素（PTH）刺激骨细胞的活动以增加血液中的钙水平，而降钙素则抑制其功能以降低血钙水平。这种复杂的激素控制确保身体维持最佳的钙水平，这对包括肌肉收缩、神经传导和血液凝固等多种生理过程至关重要。 除了在钙稳态中的作用外，骨细胞还参与骨折的修复。当骨折发生时，身体会启动一个愈合过程，包括炎症、新组织的形成，以及最终骨骼的重塑。骨细胞帮助去除受损的骨组织，从而使成骨细胞能够铺设新的骨材料。这种骨细胞与成骨细胞之间的协作对有效愈合和恢复至关重要。 然而，骨细胞和成骨细胞的活动失衡可能导致各种骨骼疾病。例如，过度的骨细胞活动可能导致如骨质疏松症等疾病，因其由于吸收增加而使骨骼变得脆弱和易碎。相反，骨细胞活动不足可能导致骨质增生，这是一种以骨骼异常密集为特征的疾病，可能导致骨骼变得脆弱和易于骨折。 对骨细胞的研究对骨相关疾病的治疗具有重要意义。了解调节骨细胞活动的机制可以导致针对骨质疏松症和其他疾病的靶向疗法的发展。例如，抑制骨细胞功能的药物，如双膦酸盐，通常被开处方以减少骨质疏松症患者的骨丧失。 总之，骨细胞是我们骨骼系统的重要组成部分，在骨吸收和重塑中发挥关键作用。它们的活动对维持钙稳态和促进骨修复至关重要。随着研究继续揭示骨细胞功能的复杂性，我们获得了宝贵的见解，以开发管理骨健康和治疗相关疾病的潜在治疗方法。理解骨细胞与成骨细胞之间的微妙平衡对促进健康的骨骼系统和确保整体健康至关重要。