ouabain

简明释义

英[ˈwɑːbɑːɪn]美[wɑːˈbeɪn]

n. G 毒毛旋花苷（用以制药，非洲人用以制毒箭）；乌本苷

英英释义

单词用法

同义词

反义词

例句

1.It's action is similar to ouabain.

其作用与哇巴因相似。

2.Myofibrillar fragmentation, swelling of the cardiac myocytes, absence of the Z line, increases of the mitochondria and collagen fibers were found in ouabain group by transmission electron microscopy.

透射电镜观察显示，哇巴因组大鼠心肌细胞肿胀，肌纤维断裂，Z线消失，线粒体增生肿胀，部分空泡化，细胞间胶原纤维增生。

3.Myofibrillar fragmentation, swelling of the cardiac myocytes, absence of the Z line, increases of the mitochondria and collagen fibers were found in ouabain group by transmission electron microscopy.

透射电镜观察显示，哇巴因组大鼠心肌细胞肿胀，肌纤维断裂，Z线消失，线粒体增生肿胀，部分空泡化，细胞间胶原纤维增生。

4.However, the effect of Berberine to prolong lethal time induced by Ouabain is less effective than Sodium Phenytoin, Quinidine and Propranolol.

但黄连素延长哇巴因对豚鼠的致死时间作用不及苯英钠、奎尼丁及心得安等药物。

5.Ouabain was added in order to induce oscillatory afterpotentials.

哇巴因诱发振荡后电位。

6.Furthermore, XT not only attenuated the positive inotropic action, but also delayed the following toxicity response induced by ouabain in the isolated left atria.

XT对哇巴因的正性肌力作用及随后出现的心肌收缩力降低的毒性反应均有明显的对抗作用。

7.Conclusion THP had the effect of decreasing the amplitude of DAD of rabbit heart induced by ouabain thus reducing the chance of triggered ventricular arrhythmia induced by DAD.

结论四氢巴马汀具有降低哇巴因诱发家兔在体心脏延迟后除极振幅的作用，从而减少由延迟后除极所引起的触发性室性心律失常的发生。

8.Methods:Anti-ouabain polyclonal antibody egg yolk(IgY) and anti-ouabain rabbit antibody(IgG) were prepared respectively.

方法：分别制备出鸡蛋黄抗哇巴因多克隆抗体及兔抗体。

9.The doctor prescribed ouabain to help manage the patient's heart condition.

医生开了乌巴因来帮助控制病人的心脏病。

10.Research has shown that ouabain can have a positive effect on cardiac contractility.

研究表明，乌巴因对心脏收缩力有积极影响。

11.In traditional medicine, ouabain was used as a poison for hunting.

在传统医学中，乌巴因被用作狩猎的毒药。

12.Clinical trials are investigating the potential benefits of ouabain in treating heart failure.

临床试验正在研究乌巴因在治疗心力衰竭中的潜在好处。

13.The mechanism of action of ouabain involves inhibiting the sodium-potassium pump.

乌巴因的作用机制涉及抑制钠钾泵。

作文

The study of biochemistry has revealed many fascinating compounds that play crucial roles in biological processes. One such compound is ouabain, a potent inhibitor of the Na+/K+ ATPase enzyme. This enzyme is essential for maintaining the electrochemical gradient across cell membranes, which is vital for various cellular functions, including muscle contraction and nerve impulse transmission. Ouabain is derived from the seeds of the African plant Strophanthus gratus and has been used traditionally as a poison on arrows for hunting due to its ability to induce cardiac arrest in prey. In modern medicine, ouabain has garnered attention for its potential therapeutic applications, particularly in treating heart conditions. It has been shown to increase the force of heart contractions, making it useful for patients with heart failure. However, the use of ouabain must be carefully monitored due to its narrow therapeutic window; too much can lead to toxicity and adverse effects, including arrhythmias. Research into ouabain has expanded beyond cardiology, as scientists explore its role in signaling pathways and cellular responses. It has been found to influence various physiological processes, such as blood pressure regulation and kidney function. The dual nature of ouabain as both a toxic agent and a potential therapeutic drug exemplifies the complexity of natural compounds in pharmacology. Furthermore, understanding how ouabain interacts with the Na+/K+ ATPase enzyme can provide insights into the development of new medications that mimic its effects without the associated risks. For instance, synthetic derivatives of ouabain are being investigated for their ability to selectively target specific tissues, thereby reducing side effects while maintaining therapeutic efficacy. In conclusion, ouabain serves as a powerful reminder of the intricate balance between nature and medicine. Its historical use as a poison contrasts sharply with its potential as a life-saving drug. As research continues, the hope is to unlock the full potential of ouabain and similar compounds, paving the way for innovative treatments that harness the power of nature while ensuring patient safety. The journey of understanding ouabain reflects the broader quest in science to transform knowledge into practical solutions that improve human health.

生物化学的研究揭示了许多在生物过程中发挥关键作用的迷人化合物。其中一种化合物是ouabain，这是一种强效的钠钾ATP酶抑制剂。该酶对于维持细胞膜的电化学梯度至关重要，这对包括肌肉收缩和神经冲动传递在内的各种细胞功能都是必不可少的。ouabain源自非洲植物Strophanthus gratus的种子，因其能够导致猎物心脏骤停而被传统用作箭毒。 在现代医学中，ouabain因其在治疗心脏病方面的潜在应用而受到关注。它已被证明可以增强心脏收缩的力量，使其对心力衰竭患者有用。然而，使用ouabain必须谨慎监测，因为其治疗窗口窄；过量可能导致毒性和不良反应，包括心律失常。 对ouabain的研究已经超越了心脏病学，科学家们正在探索其在信号通路和细胞反应中的作用。它被发现能影响多种生理过程，例如血压调节和肾功能。ouabain作为一种毒性物质和潜在治疗药物的双重性质，体现了天然化合物在药理学中的复杂性。 此外，了解ouabain如何与Na+/K+ ATP酶相互作用，可以为开发模仿其效果但没有相关风险的新药物提供见解。例如，正在研究ouabain的合成衍生物，以其能够选择性地靶向特定组织，从而减少副作用，同时保持治疗效果。 总之，ouabain强有力地提醒我们自然与医学之间的微妙平衡。它作为毒药的历史用途与作为救命药物的潜力形成鲜明对比。随着研究的继续，希望能够解锁ouabain及类似化合物的全部潜力，为利用自然力量而确保患者安全的创新治疗铺平道路。理解ouabain的旅程反映了科学更广泛的追求，即将知识转化为改善人类健康的实际解决方案。