penicillinase

简明释义

英[ˌpenɪˈsɪlɪneɪz]美[ˌpenɪˈsɪlɪˌneɪs]

n. [生化] 青霉素酶（用以治疗青霉素过敏现象）

英英释义

单词用法

同义词

反义词

例句

1.Church recalls seeing plasmid and gene sequences for the first time-penicillinase and insulin, the lac repressor and interferon.

Church回忆第一次见到了质粒和基因序列的情形-青霉素酶和胰岛素，阻遏物和干扰素。

2.Church recalls seeing plasmid and gene sequences for the first time-penicillinase and insulin, the lac repressor and interferon.

Church回忆第一次见到了质粒和基因序列的情形-青霉素酶和胰岛素，阻遏物和干扰素。

3.UV spectrophotometric method to estimate the kinetic parameters of penicillinase on penicillin substrates was established.

建立了紫外分光光度法测定青霉素酶对青霉素底物动力学参数的方法。

4.Orbenin is stable to staphylococcal penicillinase , and highly effective against resistant staphylococci.

全霉林对葡萄球菌的青霉素霉稳定，对耐药葡萄球菌十分有效。

5.Orbenin is stable to staphylococcal penicillinase and highly effective against resistant staphylococci.

全霉啉对葡萄球菌的青霉素酶稳定，对耐药葡萄球菌十分有效。

6.This test apply for the penicillinase antibiotic and none-abided penicillinase antibiotic.

本试验适用于青霉素酶的抗生素和不耐青霉素酶的青霉素类抗生素。

7.The bacteria produced penicillinase, which made them resistant to treatment.

细菌产生了青霉素酶，这使它们对治疗产生了抵抗力。

8.Doctors often test for penicillinase in bacterial infections to determine the best course of antibiotics.

医生通常会检测细菌感染中的青霉素酶以确定最佳的抗生素治疗方案。

9.In the lab, we learned how penicillinase breaks down penicillin, rendering it ineffective.

在实验室，我们了解了青霉素酶如何分解青霉素，使其失去效力。

10.Some strains of staphylococcus are known to produce penicillinase, complicating treatment.

一些金黄色葡萄球菌株已知会产生青霉素酶，使治疗变得复杂。

11.The discovery of penicillinase was a significant milestone in understanding antibiotic resistance.

对青霉素酶的发现是理解抗生素耐药性的重要里程碑。

作文

In the realm of microbiology and pharmacology, understanding the mechanisms of antibiotic resistance is crucial for developing effective treatments against bacterial infections. One significant player in this field is an enzyme known as penicillinase. This enzyme is produced by certain bacteria as a defense mechanism against the antibiotic penicillin, which was once a miracle drug in treating various bacterial infections. The discovery of penicillinase has profound implications for medical science, as it highlights the ongoing battle between antibiotics and the bacteria that evolve to resist them. Penicillin, discovered by Alexander Fleming in 1928, revolutionized medicine and significantly reduced mortality rates from bacterial infections. However, over time, some bacteria developed the ability to produce penicillinase, an enzyme that breaks down the beta-lactam ring structure of penicillin, rendering it ineffective. This resistance mechanism poses a challenge for healthcare providers, as infections caused by penicillinase-producing bacteria require alternative treatments that may not be as effective or could have more side effects. The presence of penicillinase in bacteria such as Staphylococcus aureus and Escherichia coli has led to the classification of these organisms as penicillin-resistant. This resistance can result in prolonged illness, increased healthcare costs, and higher rates of morbidity and mortality. Consequently, understanding the genetic basis of penicillinase production has become a focal point for researchers aiming to combat antibiotic resistance. To address the challenges posed by penicillinase-producing bacteria, scientists have developed a new generation of antibiotics known as beta-lactamase inhibitors. These inhibitors are designed to block the activity of penicillinase, allowing penicillin and other beta-lactam antibiotics to remain effective against resistant strains. The combination of these inhibitors with traditional antibiotics represents a promising strategy in the fight against bacterial infections. Moreover, the study of penicillinase has opened up discussions about the importance of antibiotic stewardship. Responsible prescribing practices, patient education, and public health initiatives are essential to minimize the development of resistance. Patients must understand the importance of completing their prescribed antibiotic courses and not using antibiotics for viral infections, where they are ineffective. In conclusion, the enzyme penicillinase serves as a critical example of how bacteria can adapt and survive in the face of medical advancements. The ongoing research into this enzyme and its implications for antibiotic resistance is vital for ensuring that we can continue to treat bacterial infections effectively. As we advance our understanding of penicillinase and develop new strategies to combat resistance, we must also emphasize the importance of responsible antibiotic use to preserve the efficacy of these life-saving medications for future generations.

在微生物学和药理学领域，理解抗生素耐药机制对于开发有效的细菌感染治疗至关重要。在这个领域中，一个重要的参与者是被称为青霉素酶的酶。某些细菌产生这种酶作为对抗青霉素的防御机制，而青霉素曾经是一种治疗多种细菌感染的奇迹药物。青霉素酶的发现对医学科学产生了深远的影响，因为它突显了抗生素与进化出抵抗能力的细菌之间的持续斗争。 青霉素由亚历山大·弗莱明于1928年发现，彻底改变了医学，并显著降低了细菌感染的死亡率。然而，随着时间的推移，一些细菌发展出了产生青霉素酶的能力，这种酶能够破坏青霉素的β-内酰胺环结构，使其失效。这种耐药机制给医疗提供者带来了挑战，因为由产生青霉素酶的细菌引起的感染需要替代治疗，而这些替代治疗可能不够有效或可能有更多副作用。 在金黄色葡萄球菌和大肠杆菌等细菌中存在青霉素酶使这些生物被归类为青霉素耐药性。这种耐药性可能导致疾病延长、医疗费用增加以及更高的发病率和死亡率。因此，理解青霉素酶产生的遗传基础已成为研究人员旨在对抗抗生素耐药性的重点。 为了应对由产生青霉素酶的细菌带来的挑战，科学家们开发了一种新一代抗生素，称为β-内酰胺酶抑制剂。这些抑制剂旨在阻止青霉素酶的活性，使青霉素和其他β-内酰胺抗生素能够继续对抗耐药菌株。这些抑制剂与传统抗生素的结合代表了对抗细菌感染的一种有前景的策略。 此外，对青霉素酶的研究引发了关于抗生素管理重要性的讨论。负责任的处方实践、患者教育和公共卫生倡议对于最小化耐药性的发展至关重要。患者必须理解完成所开抗生素疗程的重要性，并且不应将抗生素用于病毒感染，因为抗生素对病毒无效。 总之，酶青霉素酶作为细菌如何适应和生存于医学进步面前的关键例子。对这种酶及其对抗生素耐药性的影响的持续研究对于确保我们能够继续有效治疗细菌感染至关重要。随着我们对青霉素酶理解的深入以及开发新策略来对抗耐药性，我们还必须强调负责任使用抗生素的重要性，以保护这些拯救生命药物的有效性，为未来的世代服务。