phosphorylation

简明释义

英[ˌfɒsfərɪˈleɪʃən]美[fɒsfɒrɪˈleɪʃən]

n. [有化] 磷酸化作用

英英释义

单词用法

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例句

1.The researchers found that celecoxib decreased STAT3 phosphorylation to cause the liver cancer cells to self-destruct.

研究者发现，塞来昔布通过降低STAT 3磷酸化，使肝癌细胞走向自毁。

2.The tyrosine phosphorylation of NR2B was analyzed by immunoprecipitation and immunoblot assay.

NR2B酪氨酸磷酸化通过免疫沉淀和免疫印渍分析。

3.AIM: To understand the effect of exogenous carbon substrate on the dynamic regulation of cardiac oxidative phosphorylation.

目的：了解外源性碳源物对心肌氧化磷酸化动态调节的影响。

4.We hypothesized that such HIV suppression requires ACV phosphorylation by HHV kinases.

我们推测这种抑制作用依赖于人疱疹病毒酶导致的阿昔洛韦磷酸化。

5.In order to study the phosphorylation status of specific target proteins the phosphorylated residue of interest must remain intact.

为了研究特异靶蛋白的磷酸化状态，磷酸化的残基必须保持完整。

6.Dynamic protein phosphorylation is a key cellular signaling mechanism by which a broad spectrum of cellular processes is regulated.

动态的蛋白磷酸化是一种关键的细胞信号机制，参与调节广泛的细胞过程。

7.This can include phosphorylation, myristoylation and glycosylation.

这可以包括磷酸化，肉豆蔻酰基化和糖基化。

8.The reversible phosphorylation of proteins plays an important role in the regulation of almost all life activities.

蛋白磷酸化修饰在几乎所有的生命活动中都起重要的调节作用。

9.By way of immunoprecipitation and immunoblotting, the cytosolic protein tyrosine phosphorylation was examined.

用免疫沉淀和免疫印迹法测定胞浆蛋白酪氨酸磷酸化情况。

10.The process of phosphorylation is crucial for activating many enzymes in the cell.

在细胞中，磷酸化过程对激活许多酶至关重要。

11.During cellular signaling, phosphorylation can change the activity of proteins.

在细胞信号传递过程中，磷酸化可以改变蛋白质的活性。

12.Inhibition of phosphorylation can lead to uncontrolled cell growth.

抑制磷酸化可能导致细胞生长失控。

13.The hormone insulin triggers phosphorylation of specific proteins to regulate glucose levels.

胰岛素激素触发特定蛋白质的磷酸化以调节葡萄糖水平。

14.Research shows that phosphorylation plays a key role in cancer progression.

研究表明，磷酸化在癌症进展中发挥了关键作用。

作文

Phosphorylation is a crucial biochemical process that involves the addition of a phosphate group to a molecule, typically a protein. This process plays a vital role in regulating various cellular functions and signal transduction pathways. When a phosphate group is added to a protein, it can change the protein's shape and function, thus influencing its activity within the cell. This modification is often reversible, allowing cells to respond dynamically to changes in their environment. The significance of phosphorylation (磷酸化) cannot be overstated, as it is involved in many essential cellular processes, including metabolism, cell division, and apoptosis. For instance, in the context of insulin signaling, phosphorylation (磷酸化) allows for the regulation of glucose uptake by cells, which is critical for maintaining blood sugar levels. When insulin binds to its receptor on the cell surface, a cascade of phosphorylation (磷酸化) events occurs, leading to the activation of glucose transporters that facilitate the entry of glucose into the cell. Moreover, phosphorylation (磷酸化) is not limited to proteins; it can also occur on lipids and nucleotides, further expanding its role in cellular regulation. For example, the phosphorylation (磷酸化) of lipids can influence membrane dynamics and signaling pathways, while the phosphorylation (磷酸化) of nucleotides is critical for energy transfer and storage in the form of ATP. In terms of disease, dysregulation of phosphorylation (磷酸化) processes has been implicated in various conditions, including cancer and neurodegenerative disorders. In cancer, abnormal phosphorylation (磷酸化) can lead to uncontrolled cell growth and proliferation. Many oncogenes and tumor suppressor genes are regulated by phosphorylation (磷酸化), making it a target for therapeutic intervention. Drugs that inhibit specific kinases, the enzymes responsible for adding phosphate groups, are currently being studied and used in cancer treatments. The study of phosphorylation (磷酸化) has also led to advancements in biotechnology and medicine. Techniques such as mass spectrometry and Western blotting are employed to analyze phosphorylation (磷酸化) patterns in proteins, providing insights into their functional states and the regulatory mechanisms at play within cells. Understanding these patterns can help in the development of targeted therapies and personalized medicine approaches. In conclusion, phosphorylation (磷酸化) is a fundamental biochemical modification that regulates numerous cellular processes. Its importance in health and disease underscores the need for continued research in this area. By unraveling the complexities of phosphorylation (磷酸化), scientists hope to develop new strategies for treating diseases and improving human health. As our understanding of this process deepens, we may uncover novel pathways and mechanisms that could lead to groundbreaking therapies and interventions in the future.

磷酸化是一个关键的生化过程，涉及将磷酸基团添加到分子上，通常是蛋白质。这个过程在调节各种细胞功能和信号转导途径中起着至关重要的作用。当磷酸基团被添加到蛋白质时，它可以改变蛋白质的形状和功能，从而影响其在细胞内的活性。这种修饰通常是可逆的，使细胞能够动态响应环境的变化。 磷酸化（磷酸化）的重要性不容小觑，因为它参与许多基本的细胞过程，包括代谢、细胞分裂和细胞凋亡。例如，在胰岛素信号传导的背景下，磷酸化（磷酸化）允许调节细胞对葡萄糖的摄取，这对于维持血糖水平至关重要。当胰岛素与细胞表面的受体结合时，会发生一系列的磷酸化（磷酸化）事件，导致激活葡萄糖转运蛋白，促进葡萄糖进入细胞。 此外，磷酸化（磷酸化）不仅限于蛋白质；它也可以发生在脂质和核苷酸上，进一步扩展了其在细胞调节中的作用。例如，脂质的磷酸化（磷酸化）可以影响膜动力学和信号通路，而核苷酸的磷酸化（磷酸化）则对ATP的能量转移和储存至关重要。 在疾病方面，磷酸化（磷酸化）过程的失调与各种疾病有关，包括癌症和神经退行性疾病。在癌症中，异常的磷酸化（磷酸化）可能导致细胞生长和增殖失控。许多癌基因和肿瘤抑制基因受磷酸化（磷酸化）调节，因此成为治疗干预的目标。目前正在研究和使用针对特定激酶的药物，这些激酶是负责添加磷酸基团的酶，用于癌症治疗。 对磷酸化（磷酸化）的研究还推动了生物技术和医学的进步。质谱法和西方印迹等技术用于分析蛋白质中的磷酸化（磷酸化）模式，提供对其功能状态和细胞内调节机制的见解。理解这些模式有助于开发靶向疗法和个性化医学方法。 总之，磷酸化（磷酸化）是调节众多细胞过程的基本生化修饰。它在健康和疾病中的重要性突显了继续在这一领域进行研究的必要性。通过揭示磷酸化（磷酸化）的复杂性，科学家希望开发出新的治疗策略和改善人类健康的方法。随着我们对这一过程的理解加深，我们可能会发现新的通路和机制，未来可能会导致突破性的疗法和干预措施。