protamine

简明释义

英[ˈprəʊtəˌmiːn]美[ˈprotəmɪn]

n. [生化] 鱼精蛋白

英英释义

单词用法

同义词

反义词

例句

1.Eukaryotic nuclear proteins and viral proteins contain NLS, and the protamine is widely used as a natural NLS peptide.

NLS存在于真核细胞核蛋白及病毒蛋白中，鱼精蛋白是应用较为广泛的天然nl S类短肽。

2.The significance of antisera against protamine was discussed.

并对制备该抗血清的意义予以讨论。

3.This article reviewed its physical and chemical property, extract technics, antimicrobial principium, defection, existent question and prospect of protamine.

对鱼精蛋白的理化性质、提取工艺、抗菌机制和存在的问题及展望等方面进行了简述。

4.The main reason of coagulopathy following CPB is not insufficient protamine reversal of heparin, but the CPB itself.

CPB后凝血功能并不立即恢复正常，主要原因不是肝素中和不足，而是CPB本身使凝血功能受到损害。

5.This paper summarizes the source, composition, extraction technology for protamine, and emphasizes the antibacterial characteristic and mechanism as well as the application of protamine.

本文综述了鱼精蛋白的来源、组成、提取、纯化、防腐性能、防腐机理以及其防腐应用。

6.The catalyzing and templating function of protamine involved in the synthesis of the nanoparticle composite was discussed, and a mechanism was tentatively proposed.

对仿生钛化过程机理及精蛋白在诱导合成氧化钛过程中的催化和模板双重作用进行了详细的阐述。

7.The doctor administered protamine to reverse the effects of heparin after surgery.

医生在手术后使用鱼精蛋白来逆转肝素的效果。

8.Research shows that protamine can help in the treatment of certain types of poisoning.

研究表明，鱼精蛋白可以帮助治疗某些类型的中毒。

9.In the lab, scientists are studying the properties of protamine for drug delivery systems.

在实验室，科学家们正在研究鱼精蛋白在药物传递系统中的特性。

10.Patients with a history of allergies should inform their doctor before receiving protamine.

有过敏史的患者在接受鱼精蛋白之前应告知医生。

11.The use of protamine in cardiac surgery is crucial for managing anticoagulation.

在心脏手术中使用鱼精蛋白对管理抗凝非常重要。

作文

In the realm of biochemistry, few substances are as intriguing as protamine. This small, basic protein plays a crucial role in the field of medicine, particularly in the management of anticoagulation therapies. Protamine is primarily derived from fish sperm and is known for its ability to neutralize the effects of heparin, a commonly used anticoagulant. Understanding the significance of protamine not only sheds light on its biochemical properties but also highlights its practical applications in clinical settings. Heparin, a glycosaminoglycan, is widely administered to prevent blood clots during various medical procedures. However, its potent anticoagulant effects can sometimes lead to excessive bleeding. This is where protamine comes into play. By binding to heparin, protamine forms a stable complex that effectively reverses heparin's anticoagulant activity. This property is particularly beneficial during surgeries or in patients who experience heparin overdose, making protamine an essential tool in emergency medicine. The mechanism by which protamine interacts with heparin is fascinating. The positive charges on protamine attract the negative charges on heparin, leading to the formation of a complex that inhibits heparin’s function. This interaction is not only a testament to the intricate nature of biochemical reactions but also emphasizes the importance of understanding protein interactions in developing effective therapeutic agents. Moreover, protamine has been utilized in various formulations, including injectable solutions, to ensure rapid reversal of heparin’s effects. The dosage of protamine must be carefully calculated, as excessive amounts can lead to adverse effects, including allergic reactions or hypotension. Therefore, healthcare professionals must be well-versed in the pharmacokinetics of protamine to administer it safely and effectively. Beyond its role in anticoagulation, protamine has garnered attention in the field of drug delivery systems. Researchers are exploring the potential of protamine as a carrier for various therapeutic agents, including nucleic acids and chemotherapeutic drugs. Its ability to form complexes with negatively charged molecules makes protamine an attractive candidate for gene therapy and targeted drug delivery, paving the way for innovative treatment strategies. In conclusion, protamine is more than just a simple protein; it is a vital component in modern medicine with significant implications for patient care. From reversing the effects of heparin to its potential in drug delivery systems, protamine exemplifies the intersection of biochemistry and clinical practice. As research continues to unveil new applications for protamine, its importance in the medical field is likely to grow, further solidifying its place in the annals of biochemistry and pharmacology.

在生物化学领域，少有物质像protamine那样引人入胜。这种小型的碱性蛋白在医学领域中扮演着至关重要的角色，尤其是在抗凝治疗的管理中。Protamine主要来源于鱼精子，以其能够中和肝素（一种常用的抗凝剂）的作用而闻名。理解protamine的重要性不仅能揭示其生化特性，还能突显其在临床环境中的实际应用。 肝素是一种广泛应用于各种医疗程序中的糖胺聚糖，旨在预防血栓。然而，它强效的抗凝作用有时会导致过度出血。这就是protamine发挥作用的地方。通过与肝素结合，protamine形成一个稳定的复合物，有效逆转肝素的抗凝活性。这一特性在手术期间或在经历肝素过量的患者中尤为有益，使得protamine成为急救医学中的重要工具。 Protamine与肝素相互作用的机制令人着迷。Protamine上的正电荷吸引肝素上的负电荷，导致形成一个抑制肝素功能的复合物。这一相互作用不仅证明了生化反应的复杂性，也强调了理解蛋白质相互作用在开发有效治疗剂中的重要性。 此外，protamine已被用于各种制剂中，包括注射溶液，以确保快速逆转肝素的效果。Protamine的剂量必须仔细计算，因为过量可能导致不良反应，包括过敏反应或低血压。因此，医疗专业人员必须熟悉protamine的药代动力学，以安全有效地施用它。 除了在抗凝中的作用，protamine在药物输送系统中也引起了关注。研究人员正在探索protamine作为各种治疗剂载体的潜力，包括核酸和化疗药物。其与带负电荷分子形成复合物的能力使得protamine成为基因治疗和靶向药物输送的有吸引力的候选者，为创新治疗策略铺平了道路。 总之，protamine不仅仅是一个简单的蛋白质；它是现代医学中一个重要的组成部分，对患者护理具有重大影响。从逆转肝素的效果到在药物输送系统中的潜力，protamine体现了生物化学与临床实践的交汇点。随着研究不断揭示protamine的新应用，其在医学领域的重要性可能会进一步增长，进一步巩固其在生物化学和药理学史册中的地位。