pyrimethamine

简明释义

英[ˌpɪrɪˈmeθəmiːn]美[ˌpaɪrəˈmeθəˌmɪn]

n. 乙嘧啶；息疟定

英英释义

单词用法

同义词

反义词

例句

1.Until recently, the official treatment policy for malaria was sulfadoxine-pyrimethamine (sp). Chloroquine, however, is still widely used despite significant drug resistance.

直到最近，官方才采用了sulfadoxine -pyrimethamine (SP)的治疗方法，但氯喹的使用范围仍很广，尽管它有着很强的抗药性。

2.Until recently, the official treatment policy for malaria was sulfadoxine-pyrimethamine (sp). Chloroquine, however, is still widely used despite significant drug resistance.

直到最近，官方才采用了sulfadoxine -pyrimethamine (SP)的治疗方法，但氯喹的使用范围仍很广，尽管它有着很强的抗药性。

3.Chloroquine and antifolate drugs such as the sulphadoxine-pyrimethamine combination are safe and are still used in some regions because of their low cost.

Chloroquine和抗叶酸药物如sulphadoxine - pyrimethamine组合药物是安全的，而且仍在某些区域被使用，因为它们的价钱低。

4.Resistance to earlier generation antimalarial medicines such as chloroquine and sulfadoxine-pyrimethamine is widespread in most malaria-endemic countries.

在大多数疟疾流行国家，对氯喹和磺胺多辛+乙胺嘧啶等较早一代抗疟药物的耐药性十分普遍。

5.Malaria parasites highly resistant to chloroquine and pyrimethamine spread from Asian origins to Africa, at great cost to human health and life.

疟原虫具有很高的耐氯喹和乙胺嘧啶从亚洲传播到非洲起源，付出很大代价人类健康和生命。

6.This is the use of a single drug (or monotherapy) of chloroquine, sulfadoxine-pyrimethamine, or another antimalarial medicine to fight malaria.

这种疗法使用氯喹、磺胺多辛-乙胺嘧啶或另一种抗疟药物等单一药物治疗疟疾（亦称单一疗法）。

7.The infection is treated with drugs such as pyrimethamine, sulfadiazine and clindamycin.

对于这种感染可用乙嘧啶，磺胺嘧啶和氯林可霉素等药物进行治疗。

8.Leucovorin may also be used to prevent the side-effects of pyrimethamine.

另外，可使用亚叶酸防止乙嘧啶的副作用。

9.The doctor prescribed pyrimethamine for the treatment of malaria.

医生开了吡美Methamine用于治疗疟疾。

10.Patients taking pyrimethamine should be monitored for side effects.

服用吡美Methamine的患者应监测副作用。

11.In combination with sulfadiazine, pyrimethamine is effective against Toxoplasmosis.

与磺胺嘧啶联合使用时，吡美Methamine对弓形虫病有效。

12.The recommended dose of pyrimethamine varies based on the patient's weight.

推荐的吡美Methamine剂量根据患者体重而异。

13.Healthcare providers must educate patients about the use of pyrimethamine.

医疗提供者必须教育患者关于吡美Methamine的使用。

作文

Pyrimethamine is an important medication that plays a crucial role in the treatment of certain parasitic infections, particularly those caused by the protozoan parasite Toxoplasma gondii. This parasite is known to cause toxoplasmosis, a disease that can have severe consequences for individuals with weakened immune systems, such as those living with HIV/AIDS or undergoing chemotherapy. The significance of pyrimethamine lies not only in its effectiveness but also in the challenges associated with its use. One of the primary uses of pyrimethamine is in combination with sulfadiazine, another antimicrobial agent, to treat toxoplasmosis. This combination therapy is particularly effective because pyrimethamine works by inhibiting the enzyme dihydrofolate reductase, which is essential for the synthesis of folate in the parasite. Folate is necessary for the production of DNA and RNA, and without it, the parasite cannot multiply effectively. Therefore, by blocking this enzyme, pyrimethamine helps to control the infection and prevent its progression. In addition to treating toxoplasmosis, pyrimethamine has also been used in the prevention of malaria, especially in pregnant women and those who are at high risk of contracting the disease. Malaria is caused by Plasmodium parasites, and while there are several medications available for its treatment, pyrimethamine has been recognized for its ability to reduce the risk of malaria transmission. This preventive measure is particularly important in regions where malaria is endemic, as it helps protect vulnerable populations. Despite its benefits, the use of pyrimethamine is not without risks. One of the major concerns is the potential for side effects, which can range from mild to severe. Common side effects include nausea, vomiting, and headache. More serious side effects can involve blood disorders, such as agranulocytosis and thrombocytopenia, which can lead to complications if not monitored closely. Therefore, patients receiving pyrimethamine must be regularly evaluated by healthcare providers to ensure their safety and well-being. Moreover, the emergence of drug resistance is another challenge that healthcare professionals face when using pyrimethamine. As with many antimicrobial agents, there is a risk that the parasites may develop resistance to the medication over time, making it less effective. This highlights the importance of appropriate prescribing practices and the need for ongoing research to develop new treatments and strategies to combat these infections. In conclusion, pyrimethamine is a vital medication in the fight against parasitic infections, particularly toxoplasmosis and malaria. Its mechanism of action allows it to effectively inhibit the growth of these parasites, providing significant benefits to those affected. However, the potential for side effects and the risk of drug resistance underscore the necessity for careful management and monitoring of patients. As research continues to evolve, the hope is that new advancements will enhance our ability to utilize pyrimethamine and other treatments in the battle against infectious diseases. Understanding the role of pyrimethamine not only enhances our knowledge of pharmacology but also contributes to better health outcomes for vulnerable populations worldwide.

吡咯美特敏是一种重要的药物，在某些寄生虫感染的治疗中发挥着关键作用，特别是由原生动物寄生虫弓形虫(Toxoplasma gondii)引起的感染。该寄生虫被认为会导致弓形虫病，这种疾病对免疫系统较弱的个体（如艾滋病毒/艾滋病患者或正在接受化疗的人）可能会产生严重后果。pyrimethamine的重要性不仅在于其有效性，还在于使用过程中所面临的挑战。 pyrimethamine的主要用途之一是与磺胺嘧啶（sulfadiazine）联合使用，以治疗弓形虫病。这种联合疗法特别有效，因为pyrimethamine通过抑制寄生虫合成叶酸所必需的酶二氢叶酸还原酶，从而发挥作用。叶酸是DNA和RNA合成所必需的，没有它，寄生虫就无法有效繁殖。因此，通过阻断这种酶，pyrimethamine有助于控制感染并防止其进展。 除了治疗弓形虫病外，pyrimethamine还被用于预防疟疾，尤其是在孕妇和高风险人群中。疟疾是由疟原虫引起的，尽管有几种药物可用于治疗，但pyrimethamine因其降低疟疾传播风险的能力而受到认可。这一预防措施在疟疾流行地区尤为重要，因为它有助于保护易受感染的人群。 尽管有其好处，pyrimethamine的使用也并非没有风险。一个主要的担忧是潜在的副作用，副作用的范围从轻微到严重不等。常见的副作用包括恶心、呕吐和头痛。更严重的副作用可能涉及血液疾病，如粒细胞缺乏症和血小板减少症，如果不加以密切监测，可能会导致并发症。因此，接受pyrimethamine治疗的患者必须定期由医疗提供者评估，以确保其安全和健康。 此外，药物耐药性的出现是医疗专业人员在使用pyrimethamine时面临的另一个挑战。与许多抗微生物药物一样，寄生虫随着时间的推移可能会对药物产生耐药性，从而使其效果降低。这突显了适当开处方实践的重要性，以及开展新治疗和策略研究以对抗这些感染的必要性。 总之，pyrimethamine在抗击寄生虫感染，尤其是弓形虫病和疟疾方面是一种至关重要的药物。其作用机制使其能够有效抑制这些寄生虫的生长，为受影响者提供显著的好处。然而，潜在的副作用和药物耐药风险强调了对患者进行仔细管理和监测的必要性。随着研究的不断发展，希望新的进展能增强我们利用pyrimethamine和其他治疗方法对抗传染病的能力。理解pyrimethamine的作用不仅增强了我们对药理学的认识，也有助于改善全球易受感染人群的健康结果。